5Z12
A structure of FXR/RXR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0032052 | molecular_function | bile acid binding |
| D | 0038183 | biological_process | bile acid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 33Y A 501 |
| Chain | Residue |
| A | ILE283 |
| A | MET379 |
| A | TYR383 |
| A | TRP483 |
| A | ILE287 |
| A | LEU301 |
| A | ALA305 |
| A | HIS308 |
| A | MET342 |
| A | SER346 |
| A | ILE349 |
| A | LEU362 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 9CR C 501 |
| Chain | Residue |
| C | ILE268 |
| C | ALA272 |
| C | GLN275 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | VAL342 |
| C | CYS432 |
| C | LEU436 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 33Y D 501 |
| Chain | Residue |
| D | ILE283 |
| D | ILE287 |
| D | LEU301 |
| D | ALA305 |
| D | HIS308 |
| D | MET342 |
| D | PHE343 |
| D | ARG345 |
| D | SER346 |
| D | ILE349 |
| D | LEU362 |
| D | TYR383 |
| D | LEU465 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue 9CR B 501 |
| Chain | Residue |
| B | ALA272 |
| B | GLN275 |
| B | TRP305 |
| B | LEU309 |
| B | PHE313 |
| B | ARG316 |
| B | LEU326 |
| B | ALA327 |
| B | VAL342 |
| B | CYS432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6HL1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKC/PRKCZ","evidences":[{"source":"PubMed","id":"18668687","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"23546875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | Region: {"description":"Required for nuclear export","evidences":[{"source":"PubMed","id":"15509776","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16107141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18800767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167885","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ACL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FAL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Motif: {"description":"LXXLL motif 2"} |
| Chain | Residue | Details |
