5Z12
A structure of FXR/RXR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0038183 | biological_process | bile acid signaling pathway |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003707 | molecular_function | nuclear steroid receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003707 | molecular_function | nuclear steroid receptor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0004879 | molecular_function | nuclear receptor activity |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0032052 | molecular_function | bile acid binding |
| D | 0038183 | biological_process | bile acid signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 33Y A 501 |
| Chain | Residue |
| A | ILE283 |
| A | MET379 |
| A | TYR383 |
| A | TRP483 |
| A | ILE287 |
| A | LEU301 |
| A | ALA305 |
| A | HIS308 |
| A | MET342 |
| A | SER346 |
| A | ILE349 |
| A | LEU362 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 9CR C 501 |
| Chain | Residue |
| C | ILE268 |
| C | ALA272 |
| C | GLN275 |
| C | PHE313 |
| C | ARG316 |
| C | LEU326 |
| C | ALA327 |
| C | VAL342 |
| C | CYS432 |
| C | LEU436 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue 33Y D 501 |
| Chain | Residue |
| D | ILE283 |
| D | ILE287 |
| D | LEU301 |
| D | ALA305 |
| D | HIS308 |
| D | MET342 |
| D | PHE343 |
| D | ARG345 |
| D | SER346 |
| D | ILE349 |
| D | LEU362 |
| D | TYR383 |
| D | LEU465 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue 9CR B 501 |
| Chain | Residue |
| B | ALA272 |
| B | GLN275 |
| B | TRP305 |
| B | LEU309 |
| B | PHE313 |
| B | ARG316 |
| B | LEU326 |
| B | ALA327 |
| B | VAL342 |
| B | CYS432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 |
| Chain | Residue | Details |
| C | ARG316 | |
| C | ALA327 | |
| B | ARG316 | |
| B | ALA327 | |
| D | ARG345 | |
| D | TYR375 | |
| D | TYR383 | |
| D | HIS461 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| C | SER259 | |
| B | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 |
| Chain | Residue | Details |
| C | SER260 | |
| B | SER260 | |
| D | LYS289 |
