5YX1

Crystal structure of hematopoietic prostaglandin D synthase in complex with U004

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0019371	biological_process	cyclooxygenase pathway
A	0042803	molecular_function	protein homodimerization activity
B	0000287	molecular_function	magnesium ion binding
B	0004364	molecular_function	glutathione transferase activity
B	0004667	molecular_function	prostaglandin-D synthase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0007165	biological_process	signal transduction
B	0007626	biological_process	locomotory behavior
B	0019371	biological_process	cyclooxygenase pathway
B	0042803	molecular_function	protein homodimerization activity
C	0000287	molecular_function	magnesium ion binding
C	0004364	molecular_function	glutathione transferase activity
C	0004667	molecular_function	prostaglandin-D synthase activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0007165	biological_process	signal transduction
C	0007626	biological_process	locomotory behavior
C	0019371	biological_process	cyclooxygenase pathway
C	0042803	molecular_function	protein homodimerization activity
D	0000287	molecular_function	magnesium ion binding
D	0004364	molecular_function	glutathione transferase activity
D	0004667	molecular_function	prostaglandin-D synthase activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0007165	biological_process	signal transduction
D	0007626	biological_process	locomotory behavior
D	0019371	biological_process	cyclooxygenase pathway
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 201

Chain	Residue
A	HOH339
A	HOH353
A	HOH370
B	HOH426
B	HOH523
B	HOH527

---

site_id	AC2
Number of Residues	14
Details	binding site for residue GSH A 202

Chain	Residue
A	LYS43
A	LYS50
A	ILE51
A	PRO52
A	GLN63
A	SER64
A	HOH318
A	HOH359
A	HOH372
A	HOH378
B	ASP97
A	TYR8
A	ARG14
A	TRP39

---

site_id	AC3
Number of Residues	16
Details	binding site for residue GSH B 301

Chain	Residue
A	ASP97
B	TYR8
B	ARG14
B	TRP39
B	LYS50
B	ILE51
B	PRO52
B	GLN63
B	SER64
B	UX4302
B	HOH409
B	HOH423
B	HOH439
B	HOH467
B	HOH539
B	HOH552

---

site_id	AC4
Number of Residues	10
Details	binding site for residue UX4 B 302

Chain	Residue
A	ASP57
B	MET11
B	GLY13
B	TRP39
B	TRP104
B	TYR152
B	THR159
B	GSH301
B	HOH437
B	HOH538

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL B 303

Chain	Residue
B	GLN196
B	THR197
B	HOH435
B	HOH536
B	HOH564
D	GLN28
D	TYR29

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 201

Chain	Residue
C	HOH328
C	HOH332
C	HOH361
D	HOH430
D	HOH462
D	HOH497

---

site_id	AC7
Number of Residues	13
Details	binding site for residue GSH C 202

Chain	Residue
C	TYR8
C	ARG14
C	TRP39
C	LYS43
C	LYS50
C	ILE51
C	GLN63
C	SER64
C	UX4203
C	HOH317
C	HOH379
C	HOH389
D	ASP97

---

site_id	AC8
Number of Residues	8
Details	binding site for residue UX4 C 203

Chain	Residue
C	GLY13
C	ARG14
C	GLN36
C	MET99
C	TRP104
C	THR159
C	GSH202
C	HOH320

---

site_id	AC9
Number of Residues	16
Details	binding site for residue GSH D 301

Chain	Residue
C	ASP97
D	TYR8
D	ARG14
D	TRP39
D	LYS50
D	ILE51
D	PRO52
D	GLN63
D	SER64
D	UX4302
D	HOH403
D	HOH459
D	HOH466
D	HOH492
D	HOH542
D	HOH555

---

site_id	AD1
Number of Residues	12
Details	binding site for residue UX4 D 302

Chain	Residue
D	GLY13
D	GLN36
D	TRP39
D	TRP104
D	TYR152
D	THR159
D	GSH301
D	HOH404
D	HOH464
C	ASP57
C	LEU59
D	MET11

---

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL D 303

Chain	Residue
B	GLN28
B	TYR29
D	GLN196
D	THR197
D	HOH452
D	HOH543
D	HOH581
D	HOH597

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	308
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

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site_id	SWS_FT_FI2
Number of Residues	472
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]}

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