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5YX1

Crystal structure of hematopoietic prostaglandin D synthase in complex with U004

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001516biological_processprostaglandin biosynthetic process
A0004364molecular_functionglutathione transferase activity
A0004667molecular_functionprostaglandin-D synthase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006693biological_processprostaglandin metabolic process
A0007165biological_processsignal transduction
A0007626biological_processlocomotory behavior
A0009624biological_processresponse to nematode
A0010269biological_processresponse to selenium ion
A0016740molecular_functiontransferase activity
A0016853molecular_functionisomerase activity
A0042803molecular_functionprotein homodimerization activity
A0043231cellular_componentintracellular membrane-bounded organelle
A0046872molecular_functionmetal ion binding
A2000255biological_processnegative regulation of male germ cell proliferation
B0000287molecular_functionmagnesium ion binding
B0001516biological_processprostaglandin biosynthetic process
B0004364molecular_functionglutathione transferase activity
B0004667molecular_functionprostaglandin-D synthase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006693biological_processprostaglandin metabolic process
B0007165biological_processsignal transduction
B0007626biological_processlocomotory behavior
B0009624biological_processresponse to nematode
B0010269biological_processresponse to selenium ion
B0016740molecular_functiontransferase activity
B0016853molecular_functionisomerase activity
B0042803molecular_functionprotein homodimerization activity
B0043231cellular_componentintracellular membrane-bounded organelle
B0046872molecular_functionmetal ion binding
B2000255biological_processnegative regulation of male germ cell proliferation
C0000287molecular_functionmagnesium ion binding
C0001516biological_processprostaglandin biosynthetic process
C0004364molecular_functionglutathione transferase activity
C0004667molecular_functionprostaglandin-D synthase activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006693biological_processprostaglandin metabolic process
C0007165biological_processsignal transduction
C0007626biological_processlocomotory behavior
C0009624biological_processresponse to nematode
C0010269biological_processresponse to selenium ion
C0016740molecular_functiontransferase activity
C0016853molecular_functionisomerase activity
C0042803molecular_functionprotein homodimerization activity
C0043231cellular_componentintracellular membrane-bounded organelle
C0046872molecular_functionmetal ion binding
C2000255biological_processnegative regulation of male germ cell proliferation
D0000287molecular_functionmagnesium ion binding
D0001516biological_processprostaglandin biosynthetic process
D0004364molecular_functionglutathione transferase activity
D0004667molecular_functionprostaglandin-D synthase activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006693biological_processprostaglandin metabolic process
D0007165biological_processsignal transduction
D0007626biological_processlocomotory behavior
D0009624biological_processresponse to nematode
D0010269biological_processresponse to selenium ion
D0016740molecular_functiontransferase activity
D0016853molecular_functionisomerase activity
D0042803molecular_functionprotein homodimerization activity
D0043231cellular_componentintracellular membrane-bounded organelle
D0046872molecular_functionmetal ion binding
D2000255biological_processnegative regulation of male germ cell proliferation
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue MG A 201
ChainResidue
AHOH339
AHOH353
AHOH370
BHOH426
BHOH523
BHOH527

site_idAC2
Number of Residues14
Detailsbinding site for residue GSH A 202
ChainResidue
ALYS43
ALYS50
AILE51
APRO52
AGLN63
ASER64
AHOH318
AHOH359
AHOH372
AHOH378
BASP97
ATYR8
AARG14
ATRP39

site_idAC3
Number of Residues16
Detailsbinding site for residue GSH B 301
ChainResidue
AASP97
BTYR8
BARG14
BTRP39
BLYS50
BILE51
BPRO52
BGLN63
BSER64
BUX4302
BHOH409
BHOH423
BHOH439
BHOH467
BHOH539
BHOH552

site_idAC4
Number of Residues10
Detailsbinding site for residue UX4 B 302
ChainResidue
AASP57
BMET11
BGLY13
BTRP39
BTRP104
BTYR152
BTHR159
BGSH301
BHOH437
BHOH538

site_idAC5
Number of Residues7
Detailsbinding site for residue GOL B 303
ChainResidue
BGLN196
BTHR197
BHOH435
BHOH536
BHOH564
DGLN28
DTYR29

site_idAC6
Number of Residues6
Detailsbinding site for residue MG C 201
ChainResidue
CHOH328
CHOH332
CHOH361
DHOH430
DHOH462
DHOH497

site_idAC7
Number of Residues13
Detailsbinding site for residue GSH C 202
ChainResidue
CTYR8
CARG14
CTRP39
CLYS43
CLYS50
CILE51
CGLN63
CSER64
CUX4203
CHOH317
CHOH379
CHOH389
DASP97

site_idAC8
Number of Residues8
Detailsbinding site for residue UX4 C 203
ChainResidue
CGLY13
CARG14
CGLN36
CMET99
CTRP104
CTHR159
CGSH202
CHOH320

site_idAC9
Number of Residues16
Detailsbinding site for residue GSH D 301
ChainResidue
CASP97
DTYR8
DARG14
DTRP39
DLYS50
DILE51
DPRO52
DGLN63
DSER64
DUX4302
DHOH403
DHOH459
DHOH466
DHOH492
DHOH542
DHOH555

site_idAD1
Number of Residues12
Detailsbinding site for residue UX4 D 302
ChainResidue
DGLY13
DGLN36
DTRP39
DTRP104
DTYR152
DTHR159
DGSH301
DHOH404
DHOH464
CASP57
CLEU59
DMET11

site_idAD2
Number of Residues8
Detailsbinding site for residue GOL D 303
ChainResidue
BGLN28
BTYR29
DGLN196
DTHR197
DHOH452
DHOH543
DHOH581
DHOH597

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518
ChainResidueDetails
ATYR8
BGLN63
CTYR8
CARG14
CTRP39
CGLY49
CGLN63
DTYR8
DARG14
DTRP39
DGLY49
AARG14
DGLN63
ATRP39
AGLY49
AGLN63
BTYR8
BARG14
BTRP39
BGLY49

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PDB entries from 2024-10-30

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