5YWX

Crystal structure of hematopoietic prostaglandin D synthase in complex with F092

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004364	molecular_function	glutathione transferase activity
A	0004667	molecular_function	prostaglandin-D synthase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0007165	biological_process	signal transduction
A	0007626	biological_process	locomotory behavior
A	0019371	biological_process	cyclooxygenase pathway
A	0042803	molecular_function	protein homodimerization activity
B	0000287	molecular_function	magnesium ion binding
B	0004364	molecular_function	glutathione transferase activity
B	0004667	molecular_function	prostaglandin-D synthase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0007165	biological_process	signal transduction
B	0007626	biological_process	locomotory behavior
B	0019371	biological_process	cyclooxygenase pathway
B	0042803	molecular_function	protein homodimerization activity
C	0000287	molecular_function	magnesium ion binding
C	0004364	molecular_function	glutathione transferase activity
C	0004667	molecular_function	prostaglandin-D synthase activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0007165	biological_process	signal transduction
C	0007626	biological_process	locomotory behavior
C	0019371	biological_process	cyclooxygenase pathway
C	0042803	molecular_function	protein homodimerization activity
D	0000287	molecular_function	magnesium ion binding
D	0004364	molecular_function	glutathione transferase activity
D	0004667	molecular_function	prostaglandin-D synthase activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0007165	biological_process	signal transduction
D	0007626	biological_process	locomotory behavior
D	0019371	biological_process	cyclooxygenase pathway
D	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue GSH A 301

Chain	Residue
A	TYR8
A	HOH461
A	HOH468
A	HOH502
A	HOH514
B	ASP97
A	ARG14
A	TRP39
A	LYS50
A	ILE51
A	PRO52
A	GLN63
A	SER64
A	93C302

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 93C A 302

Chain	Residue
A	MET11
A	GLY13
A	ARG14
A	GLN36
A	MET99
A	TRP104
A	ALA105
A	TYR152
A	LEU199
A	GSH301
A	HOH421
A	HOH442
A	HOH503
B	GLY58

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GOL A 303

Chain	Residue
A	GLN196
A	THR197
A	HOH415
A	HOH444
A	HOH505
A	HOH542
D	GLN28
D	TYR29
D	GOL303

---

site_id	AC4
Number of Residues	7
Details	binding site for residue GOL A 304

Chain	Residue
A	GLN28
A	TYR29
A	HOH428
A	HOH520
D	GLN196
D	THR197
D	LYS198

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MG B 201

Chain	Residue
A	HOH456
A	HOH488
A	HOH529
B	HOH304
B	HOH322
B	HOH329

---

site_id	AC6
Number of Residues	13
Details	binding site for residue GSH B 202

Chain	Residue
A	ASP97
B	TYR8
B	ARG14
B	TRP39
B	LYS43
B	GLY49
B	LYS50
B	ILE51
B	PRO52
B	GLN63
B	SER64
B	HOH328
B	HOH350

---

site_id	AC7
Number of Residues	8
Details	binding site for residue 93C B 203

Chain	Residue
B	GLY13
B	ARG14
B	GLN36
B	MET99
B	TRP104
B	ALA105
B	TYR152
B	HOH321

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG C 201

Chain	Residue
C	HOH322
C	HOH329
C	HOH334
D	HOH452
D	HOH483
D	HOH485

---

site_id	AC9
Number of Residues	13
Details	binding site for residue GSH C 202

Chain	Residue
C	TYR8
C	ARG14
C	TRP39
C	LYS43
C	LYS50
C	ILE51
C	PRO52
C	GLN63
C	SER64
C	93C203
C	HOH325
C	HOH336
D	ASP97

---

site_id	AD1
Number of Residues	11
Details	binding site for residue 93C C 203

Chain	Residue
C	GSH202
C	HOH310
C	MET11
C	GLY13
C	ARG14
C	GLN36
C	MET99
C	TRP104
C	ALA105
C	TYR152
C	LEU199

---

site_id	AD2
Number of Residues	12
Details	binding site for residue GSH D 301

Chain	Residue
C	ASP97
D	TYR8
D	ARG14
D	TRP39
D	LYS50
D	ILE51
D	PRO52
D	GLN63
D	SER64
D	93C302
D	HOH430
D	HOH459

---

site_id	AD3
Number of Residues	13
Details	binding site for residue 93C D 302

Chain	Residue
C	LEU59
D	MET11
D	GLY13
D	ARG14
D	GLN36
D	MET99
D	TRP104
D	ALA105
D	TYR152
D	LEU199
D	GSH301
D	HOH416
D	HOH446

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL D 303

Chain	Residue
A	LYS198
A	GOL303
D	GLN28
D	TYR29
D	HOH415
D	HOH436
D	HOH540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	308
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	472
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12627223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15113825","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16547010","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18341273","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19939518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---