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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5YU6

CRYSTAL STRUCTURE OF EXPORTIN-5:RANGTP COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006405biological_processRNA export from nucleus
A0006611biological_processprotein export from nucleus
A0006886biological_processintracellular protein transport
A0010586biological_processmiRNA metabolic process
A0015031biological_processprotein transport
A0016442cellular_componentRISC complex
A0031047biological_processregulatory ncRNA-mediated gene silencing
A0031267molecular_functionsmall GTPase binding
A0035281biological_processpre-miRNA export from nucleus
A0042565cellular_componentRNA nuclear export complex
A0070883molecular_functionpre-miRNA binding
A1905172molecular_functionRISC complex binding
B0000054biological_processribosomal subunit export from nucleus
B0000070biological_processmitotic sister chromatid segregation
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0003924molecular_functionGTPase activity
B0005049molecular_functionnuclear export signal receptor activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006606biological_processprotein import into nucleus
B0006611biological_processprotein export from nucleus
B0006913biological_processnucleocytoplasmic transport
B0015031biological_processprotein transport
B0016442cellular_componentRISC complex
B0016787molecular_functionhydrolase activity
B0032991cellular_componentprotein-containing complex
B0035281biological_processpre-miRNA export from nucleus
B0042470cellular_componentmelanosome
B0046039biological_processGTP metabolic process
B0046827biological_processpositive regulation of protein export from nucleus
B0046872molecular_functionmetal ion binding
B0051301biological_processcell division
B0061015biological_processsnRNA import into nucleus
B0070883molecular_functionpre-miRNA binding
B1905172molecular_functionRISC complex binding
C0000049molecular_functiontRNA binding
C0003723molecular_functionRNA binding
C0003729molecular_functionmRNA binding
C0005049molecular_functionnuclear export signal receptor activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006405biological_processRNA export from nucleus
C0006611biological_processprotein export from nucleus
C0006886biological_processintracellular protein transport
C0010586biological_processmiRNA metabolic process
C0015031biological_processprotein transport
C0016442cellular_componentRISC complex
C0031047biological_processregulatory ncRNA-mediated gene silencing
C0031267molecular_functionsmall GTPase binding
C0035281biological_processpre-miRNA export from nucleus
C0042565cellular_componentRNA nuclear export complex
C0070883molecular_functionpre-miRNA binding
C1905172molecular_functionRISC complex binding
D0000054biological_processribosomal subunit export from nucleus
D0000070biological_processmitotic sister chromatid segregation
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0003924molecular_functionGTPase activity
D0005049molecular_functionnuclear export signal receptor activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006606biological_processprotein import into nucleus
D0006611biological_processprotein export from nucleus
D0006913biological_processnucleocytoplasmic transport
D0015031biological_processprotein transport
D0016442cellular_componentRISC complex
D0016787molecular_functionhydrolase activity
D0032991cellular_componentprotein-containing complex
D0035281biological_processpre-miRNA export from nucleus
D0042470cellular_componentmelanosome
D0046039biological_processGTP metabolic process
D0046827biological_processpositive regulation of protein export from nucleus
D0046872molecular_functionmetal ion binding
D0051301biological_processcell division
D0061015biological_processsnRNA import into nucleus
D0070883molecular_functionpre-miRNA binding
D1905172molecular_functionRISC complex binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
Detailsbinding site for residue GTP B 301
ChainResidue
BGLY20
BTYR39
BALA41
BTHR42
BALA67
BGLY68
BASN122
BLYS123
BASP125
BSER150
BALA151
BTHR21
BLYS152
BMG302
BGLY22
BLYS23
BTHR24
BTHR25
BGLU36
BLYS37
BLYS38
site_idAC2
Number of Residues5
Detailsbinding site for residue MG B 302
ChainResidue
BTHR24
BTHR42
BASP65
BTHR66
BGTP301
site_idAC3
Number of Residues24
Detailsbinding site for residue GTP D 301
ChainResidue
DASP18
DGLY19
DGLY20
DTHR21
DGLY22
DLYS23
DTHR24
DTHR25
DPHE35
DGLU36
DLYS37
DLYS38
DTYR39
DALA41
DTHR42
DGLY68
DASN122
DLYS123
DASP125
DILE126
DSER150
DALA151
DLYS152
DMG302
site_idAC4
Number of Residues3
Detailsbinding site for residue MG D 302
ChainResidue
DTHR24
DTHR42
DGTP301
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues214
DetailsRegion: {"description":"Necessary for interaction with ILF3"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsRegion: {"description":"Pre-miRNA binding","evidences":[{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsSite: {"description":"Pre-miRNA binding","evidences":[{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues106
DetailsRegion: {"description":"Necessary for interaction with Ran"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues328
DetailsDomain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues16
DetailsRegion: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues32
DetailsRegion: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9533885","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9878368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BXQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsSite: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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