5YQ2
Crystal structure of E.coli aminopeptidase N in complex with Puromycin aminonucleoside
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | HOH1030 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue GMC A 902 |
| Chain | Residue |
| A | ARG825 |
| A | GLU828 |
| A | MLI905 |
| A | HOH1001 |
| A | HOH1111 |
| A | HOH1189 |
| A | HOH1326 |
| A | HOH1373 |
| A | HOH1529 |
| A | HOH1651 |
| A | MET260 |
| A | TYR376 |
| A | LEU378 |
| A | TYR381 |
| A | GLU382 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 903 |
| Chain | Residue |
| A | HIS435 |
| A | ARG438 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 904 |
| Chain | Residue |
| A | LEU532 |
| A | TRP546 |
| A | SER563 |
| A | ASP566 |
| A | ALA567 |
| A | SER570 |
| A | HOH1142 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue MLI A 905 |
| Chain | Residue |
| A | GLY261 |
| A | ALA262 |
| A | ARG293 |
| A | HIS297 |
| A | GLU298 |
| A | TYR381 |
| A | GMC902 |
| A | HOH1001 |
| A | HOH1030 |
| A | HOH1189 |
| A | HOH1317 |
| A | HOH1651 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MLI A 906 |
| Chain | Residue |
| A | PHE704 |
| A | HIS705 |
| A | ALA707 |
| A | LYS738 |
| A | TRP739 |
| A | HOH1022 |
| A | HOH1080 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIGHEYFHNW |
| Chain | Residue | Details |
| A | VAL294-TRP303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
