5YP4
Crystal structure of dipeptidyl peptidase IV (DPP IV) with Lys-Pro from Pseudoxanthomonas mexicana WO24
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0008236 | molecular_function | serine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | ARG106 |
| A | ILE107 |
| A | ALA108 |
| A | ALA109 |
| A | HOH904 |
| A | HOH1281 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | GLN105 |
| A | ASP115 |
| A | HOH1061 |
| A | HOH1243 |
| A | LYS43 |
| A | GLU98 |
| A | ARG101 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 805 |
| Chain | Residue |
| A | THR333 |
| A | SER334 |
| A | THR335 |
| A | ARG358 |
| A | HOH1072 |
| A | HOH1214 |
| A | HOH1346 |
| B | THR333 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 806 |
| Chain | Residue |
| A | THR450 |
| A | ARG484 |
| A | HOH1320 |
| A | HOH1338 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 803 |
| Chain | Residue |
| B | THR450 |
| B | ARG484 |
| B | HOH1292 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 804 |
| Chain | Residue |
| A | LYS312 |
| A | THR333 |
| A | SER334 |
| A | THR335 |
| A | HOH1198 |
| B | THR331 |
| B | THR333 |
| B | ARG358 |
| B | HOH1139 |
| B | HOH1175 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 805 |
| Chain | Residue |
| B | ALA498 |
| B | ARG564 |
| B | VAL584 |
| B | ASP587 |
| B | HOH1186 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 806 |
| Chain | Residue |
| B | GLY405 |
| B | ALA406 |
| B | PRO503 |
| B | HIS505 |
| B | ARG569 |
| B | HOH948 |
| B | HOH995 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 807 |
| Chain | Residue |
| B | ARG106 |
| B | ILE107 |
| B | ALA108 |
| B | ALA109 |
| B | ARG724 |
| B | HOH915 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 808 |
| Chain | Residue |
| B | ARG293 |
| B | VAL294 |
| B | ASP295 |
| B | ASN342 |
| B | HOH1183 |
| B | HOH1200 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 809 |
| Chain | Residue |
| B | ARG106 |
| B | TYR527 |
| B | LYS801 |
| B | PRO802 |
| B | HOH945 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 810 |
| Chain | Residue |
| B | ASP449 |
| B | THR490 |
| B | ALA491 |
| B | TYR492 |
| B | ARG537 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue GOL B 811 |
| Chain | Residue |
| B | GLU97 |
| B | ARG101 |
| B | VAL201 |
| B | ALA202 |
| B | ASP207 |
| B | HIS213 |
| B | THR214 |
| B | HOH916 |
| B | HOH1000 |
| B | HOH1114 |
| B | HOH1180 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 812 |
| Chain | Residue |
| B | GLU98 |
| B | ARG101 |
| B | GLN105 |
| B | ASP115 |
| B | HOH939 |
| B | HOH1057 |
| B | HOH1085 |
| B | HOH1157 |
| site_id | AD6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 803 |
| Chain | Residue |
| C | HOH1389 |
| C | ARG542 |
| C | SER543 |
| C | ASP544 |
| C | TRP612 |
| C | ARG731 |
| C | HOH951 |
| C | HOH953 |
| C | HOH1164 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 804 |
| Chain | Residue |
| C | THR31 |
| C | GLY725 |
| C | HOH925 |
| C | HOH1027 |
| C | HOH1114 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 803 |
| Chain | Residue |
| C | HOH1080 |
| D | ARG564 |
| D | ASP587 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 804 |
| Chain | Residue |
| D | ARG106 |
| D | ILE107 |
| D | ALA108 |
| D | ALA109 |
| D | ARG724 |
| D | HOH949 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 805 |
| Chain | Residue |
| D | ASP121 |
| D | PHE135 |
| D | GLY165 |
| D | LEU181 |
| D | HOH1128 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 806 |
| Chain | Residue |
| D | THR450 |
| D | VAL473 |
| D | ARG484 |
| D | HOH906 |
| D | HOH1003 |
| D | HOH1223 |
| D | HOH1310 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 807 |
| Chain | Residue |
| D | LYS43 |
| D | GLU98 |
| D | ARG101 |
| D | GLN105 |
| D | ASP115 |
| D | HOH901 |
| D | HOH996 |
| D | HOH1165 |
| site_id | AE4 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide LYS A 801 and PRO A 802 |
| Chain | Residue |
| A | ARG106 |
| A | GLU208 |
| A | GLU209 |
| A | ASP211 |
| A | TYR527 |
| A | SER613 |
| A | ASN614 |
| A | TYR645 |
| A | TYR649 |
| A | ASN691 |
| A | HOH1226 |
| A | HOH1452 |
| site_id | AE5 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide LYS B 801 and PRO B 802 |
| Chain | Residue |
| B | ARG106 |
| B | GLU208 |
| B | GLU209 |
| B | TYR527 |
| B | SER613 |
| B | ASN614 |
| B | TYR645 |
| B | TYR649 |
| B | ASN691 |
| B | GOL809 |
| B | HOH1341 |
| site_id | AE6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide PRO B 802 and SER B 613 |
| Chain | Residue |
| B | TYR527 |
| B | TRP612 |
| B | ASN614 |
| B | GLY615 |
| B | GLY616 |
| B | TYR617 |
| B | GLY636 |
| B | ALA637 |
| B | TYR645 |
| B | TYR649 |
| B | VAL692 |
| B | HIS721 |
| B | LYS801 |
| B | GOL809 |
| site_id | AE7 |
| Number of Residues | 9 |
| Details | binding site for Di-peptide LYS C 801 and PRO C 802 |
| Chain | Residue |
| C | GLU209 |
| C | TYR527 |
| C | SER613 |
| C | ASN614 |
| C | TYR645 |
| C | TYR649 |
| C | ASN691 |
| C | HOH901 |
| C | HOH1252 |
| site_id | AE8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide LYS D 801 and PRO D 802 |
| Chain | Residue |
| D | ARG106 |
| D | GLU208 |
| D | GLU209 |
| D | TYR527 |
| D | SER613 |
| D | ASN614 |
| D | TYR645 |
| D | TYR649 |
| D | ASN691 |
| D | HOH1448 |
| site_id | AE9 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide PRO D 802 and SER D 613 |
| Chain | Residue |
| D | TYR527 |
| D | TRP612 |
| D | ASN614 |
| D | GLY615 |
| D | GLY616 |
| D | TYR617 |
| D | GLY636 |
| D | ALA637 |
| D | PRO638 |
| D | TYR645 |
| D | TYR649 |
| D | HIS721 |
| D | LYS801 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q12884","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU10084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q12884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q12884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
