5YG4
Plasmodium vivax SHMT bound with PLP-glycine and S-GS849
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0032259 | biological_process | methylation |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| B | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019264 | biological_process | glycine biosynthetic process from serine |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0032259 | biological_process | methylation |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0032259 | biological_process | methylation |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue PLG A 501 |
| Chain | Residue |
| A | SER34 |
| A | HIS211 |
| A | THR234 |
| A | HIS236 |
| A | LYS237 |
| A | ARG371 |
| B | TYR54 |
| B | TYR64 |
| B | GLY271 |
| B | GLY272 |
| B | HOH612 |
| A | SER100 |
| B | HOH649 |
| A | GLY101 |
| A | SER102 |
| A | HIS129 |
| A | TYR182 |
| A | THR183 |
| A | ASP208 |
| A | SER210 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue 8UF A 502 |
| Chain | Residue |
| A | LEU124 |
| A | GLY128 |
| A | HIS129 |
| A | LEU130 |
| A | THR183 |
| A | SER184 |
| A | LYS355 |
| A | THR357 |
| A | CYS364 |
| A | ARG371 |
| A | HOH677 |
| A | HOH704 |
| B | GLU56 |
| B | TYR63 |
| B | TYR64 |
| B | HOH621 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | ASN276 |
| A | LYS277 |
| B | ASN276 |
| B | LYS277 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | GLN78 |
| A | GLY93 |
| A | VAL94 |
| A | PHE249 |
| A | GLU258 |
| A | ASN262 |
| A | HOH615 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue PLG B 501 |
| Chain | Residue |
| A | TYR54 |
| A | TYR64 |
| A | GLY272 |
| A | HOH638 |
| B | SER34 |
| B | SER100 |
| B | GLY101 |
| B | SER102 |
| B | HIS129 |
| B | TYR182 |
| B | THR183 |
| B | ASP208 |
| B | SER210 |
| B | HIS211 |
| B | THR234 |
| B | HIS236 |
| B | LYS237 |
| B | ARG371 |
| B | HOH657 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue 8UF B 502 |
| Chain | Residue |
| A | GLU56 |
| A | TYR63 |
| A | TYR64 |
| B | LEU124 |
| B | GLY128 |
| B | HIS129 |
| B | LEU130 |
| B | THR183 |
| B | LYS355 |
| B | ASN356 |
| B | CYS364 |
| B | ARG371 |
| B | HOH607 |
| B | HOH691 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | GLN78 |
| B | GLY93 |
| B | VAL94 |
| B | GLU258 |
| B | ASN262 |
| B | HOH666 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for residue PLG C 501 |
| Chain | Residue |
| C | THR234 |
| C | HIS236 |
| C | LYS237 |
| C | GLY271 |
| C | GLY272 |
| C | ARG371 |
| C | HOH620 |
| C | SER34 |
| C | TYR54 |
| C | GLU56 |
| C | TYR64 |
| C | SER100 |
| C | GLY101 |
| C | SER102 |
| C | HIS129 |
| C | TYR182 |
| C | THR183 |
| C | ASP208 |
| C | SER210 |
| C | HIS211 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | binding site for residue 8UF C 502 |
| Chain | Residue |
| C | GLU56 |
| C | TYR63 |
| C | TYR64 |
| C | LEU124 |
| C | GLY128 |
| C | HIS129 |
| C | LEU130 |
| C | VAL141 |
| C | THR183 |
| C | SER184 |
| C | LYS355 |
| C | ASN356 |
| C | THR357 |
| C | CYS364 |
| C | ARG371 |
| C | HOH606 |
| C | HOH647 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 503 |
| Chain | Residue |
| C | ASN276 |
| C | ASN276 |
| C | LYS277 |
| C | LYS277 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | GLN78 |
| C | GLY93 |
| C | VAL94 |
| C | PHE249 |
| C | GLU258 |
| C | ASN262 |
