5YEI

Mechanistic insight into the regulation of Pseudomonas aeruginosa aspartate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004072	molecular_function	aspartate kinase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009090	biological_process	homoserine biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019877	biological_process	diaminopimelate biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004072	molecular_function	aspartate kinase activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009085	biological_process	lysine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009090	biological_process	homoserine biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019877	biological_process	diaminopimelate biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0004072	molecular_function	aspartate kinase activity
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0009085	biological_process	lysine biosynthetic process
E	0009088	biological_process	threonine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0009090	biological_process	homoserine biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019877	biological_process	diaminopimelate biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0004072	molecular_function	aspartate kinase activity
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009085	biological_process	lysine biosynthetic process
G	0009088	biological_process	threonine biosynthetic process
G	0009089	biological_process	lysine biosynthetic process via diaminopimelate
G	0009090	biological_process	homoserine biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019877	biological_process	diaminopimelate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue THR D 501

Chain	Residue
C	ASN371
C	ILE372
D	THR274
D	PRO275
D	GLY276
D	VAL277
D	ALA278
D	GLN297
D	HOH601

---

site_id	AC2
Number of Residues	10
Details	binding site for residue THR B 501

Chain	Residue
A	ASN371
A	ILE372
B	ASP273
B	THR274
B	PRO275
B	GLY276
B	VAL277
B	ALA278
B	GLN297
B	HOH603

---

site_id	AC3
Number of Residues	8
Details	binding site for residue THR F 501

Chain	Residue
E	ASP273
E	THR274
E	GLY276
E	VAL277
E	ALA278
E	GLN297
F	ASN371
F	ILE372

---

site_id	AC4
Number of Residues	10
Details	binding site for residue THR F 502

Chain	Residue
E	ASN371
E	ILE372
F	ASP273
F	THR274
F	PRO275
F	GLY276
F	VAL277
F	ALA278
F	GLN297
F	HOH602

---

site_id	AC5
Number of Residues	9
Details	binding site for residue THR C 501

Chain	Residue
C	ASP273
C	THR274
C	PRO275
C	GLY276
C	VAL277
C	ALA278
C	GLN297
D	ASN371
D	ILE372

---

site_id	AC6
Number of Residues	12
Details	binding site for residue LYS C 502

Chain	Residue
C	MET351
C	HIS354
C	ALA355
C	GLY356
C	VAL357
C	ALA358
C	SER359
C	HOH601
C	HOH612
D	LEU282
D	SER286
D	VAL292

---

site_id	AC7
Number of Residues	10
Details	binding site for residue THR H 501

Chain	Residue
G	ASN371
G	ILE372
G	HOH613
H	ASP273
H	THR274
H	GLY276
H	VAL277
H	ALA278
H	GLN297
H	HOH601

---

site_id	AC8
Number of Residues	5
Details	binding site for residue GOL G 501

Chain	Residue
G	LYS7
G	GLY9
G	GLY10
G	SER41
G	SER153

---

site_id	AC9
Number of Residues	14
Details	binding site for residue LYS G 502

Chain	Residue
G	MET351
G	HIS354
G	GLY356
G	VAL357
G	ALA358
G	THR377
G	SER378
G	GLU379
G	VAL382
G	HOH609
G	HOH614
H	VAL292
H	ASP293
H	ILE295

---

site_id	AD1
Number of Residues	9
Details	binding site for residue THR G 503

Chain	Residue
G	ASP273
G	THR274
G	PRO275
G	GLY276
G	VAL277
G	ALA278
G	GLN297
H	ASN371
H	ILE372

---

site_id	AD2
Number of Residues	14
Details	binding site for residue LYS A 501

Chain	Residue
A	GLY356
A	VAL357
A	ALA358
A	THR377
A	SER378
A	LYS381
A	VAL382
A	HOH605
B	VAL292
B	ASP293
B	ILE295
A	MET351
A	HIS354
A	ALA355

---

site_id	AD3
Number of Residues	10
Details	binding site for residue THR A 502

Chain	Residue
A	ASP273
A	THR274
A	PRO275
A	GLY276
A	VAL277
A	ALA278
A	GLN297
A	HOH607
B	ASN371
B	ILE372

---

site_id	AD4
Number of Residues	1
Details	binding site for residue GOL E 501

Chain	Residue
E	SER106

---

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL E 502

Chain	Residue
E	LYS7
E	GLY9
E	GLY10
E	SER41

---

site_id	AD6
Number of Residues	12
Details	binding site for residue LYS E 503

Chain	Residue
E	MET351
E	HIS354
E	ALA355
E	GLY356
E	VAL357
E	ALA358
E	THR377
E	SER378
E	GLU379
E	HOH602
F	VAL292
F	ASP293

---

site_id	AD7
Number of Residues	22
Details	binding site for Di-peptide ILE E 57 and LYS G 87

Chain	Residue
E	VAL16
E	LEU53
E	ALA54
E	ASN55
E	GLN56
E	MET58
E	MET83
E	LEU85
E	ILE86
E	ARG88
E	GLY89
G	GLU20
G	LEU53
G	ALA54
G	ASN55
G	GLN56
G	MET58
G	MET83
G	LEU85
G	ILE86
G	ARG88
G	GLY89

---

site_id	AD8
Number of Residues	7
Details	binding site for Di-peptide GLU H 250 and GLU H 403

Chain	Residue
H	GLN251
H	PRO252
H	ILE253
H	ILE254
H	ALA401
H	PHE402
H	LEU404

---

site_id	AD9
Number of Residues	7
Details	binding site for Di-peptide GLU H 250 and GLU H 403

Chain	Residue
H	GLN251
H	PRO252
H	ILE253
H	ILE254
H	ALA401
H	PHE402
H	LEU404

---

Functional Information from PROSITE/UniProt

site_id	PS00324
Number of Residues	9
Details	ASPARTOKINASE Aspartokinase signature. VqKFGGTSV

Chain	Residue	Details
C	VAL5-VAL13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	592
Details	Domain: {"description":"ACT 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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