Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5YBG

Crystal structure of the GluA2o LBD in complex with glutamate and LY451395

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GLU A 901

Chain	Residue
A	TYR471
A	TYR753
A	HOH1019
A	HOH1046
A	HOH1066
A	PRO499
A	LEU500
A	THR501
A	ARG506
A	GLY674
A	SER675
A	THR676
A	GLU726

site_id	AC2
Number of Residues	19
Details	binding site for residue 8SO A 902

Chain	Residue
A	LYS514
A	PRO515
A	MET517
A	SER518
A	SER750
A	LYS751
A	GLY752
A	LEU772
A	ASN775
A	GOL905
B	LYS514
B	PRO515
B	MET517
B	SER518
B	SER750
B	LYS751
B	GLY752
B	LEU772
B	ASN775

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN A 903

Chain	Residue
A	HIS433
A	ACT904
A	HOH1004

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 904

Chain	Residue
A	LYS430
A	HIS433
A	ZN903
A	HOH1004

site_id	AC5
Number of Residues	11
Details	binding site for residue GOL A 905

Chain	Residue
A	PHE516
A	MET517
A	SER518
A	LEU780
A	ASP781
A	LYS784
A	8SO902
A	HOH1002
A	HOH1012
A	HOH1029
B	SER750

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 906

Chain	Residue
A	GLU452
A	HIS456
C	GLU699
C	HOH2321

site_id	AC7
Number of Residues	13
Details	binding site for residue GLU B 901

Chain	Residue
B	TYR471
B	PRO499
B	LEU500
B	THR501
B	ARG506
B	GLY674
B	SER675
B	THR676
B	GLU726
B	TYR753
B	HOH1022
B	HOH1029
B	HOH1037

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN B 902

Chain	Residue
B	GLU452
B	HIS456
B	LEU774
B	GLN777
B	HOH1002
B	HOH1172

site_id	AC9
Number of Residues	13
Details	binding site for residue GLU C 801

Chain	Residue
C	TYR471
C	PRO499
C	LEU500
C	THR501
C	ARG506
C	GLY674
C	SER675
C	THR676
C	GLU726
C	TYR753
C	HOH2135
C	HOH2144
C	HOH2231

site_id	AD1
Number of Residues	20
Details	binding site for residue 8SO C 802

Chain	Residue
D	SER518
D	SER750
D	LYS751
D	GLY752
D	LEU772
D	ASN775
D	HOH1061
C	LYS514
C	PRO515
C	MET517
C	SER518
C	SER750
C	LYS751
C	GLY752
C	LEU772
C	ASN775
D	LYS514
D	PRO515
D	PHE516
D	MET517

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN C 803

Chain	Residue
C	HIS433
C	GLU440
C	HOH2326

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN C 804

Chain	Residue
C	GLU452
C	HIS456
C	LEU774
C	HOH2320

site_id	AD4
Number of Residues	4
Details	binding site for residue ACT C 805

Chain	Residue
C	ARG713
C	LYS720
C	TYR721
C	HOH2241

site_id	AD5
Number of Residues	8
Details	binding site for residue ACT C 806

Chain	Residue
C	PHE512
C	LYS514
C	ARG764
C	ASN768
D	PHE512
D	LYS514
D	ARG764
D	ASN768

site_id	AD6
Number of Residues	14
Details	binding site for residue GLU D 901

Chain	Residue
D	TYR471
D	PRO499
D	LEU500
D	THR501
D	ARG506
D	LEU671
D	GLY674
D	SER675
D	THR676
D	GLU726
D	TYR753
D	HOH1026
D	HOH1041
D	HOH1132

site_id	AD7
Number of Residues	2
Details	binding site for residue ZN D 902

Chain	Residue
D	HIS433
D	GLU440

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 903

Chain	Residue
D	GLU452
D	HIS456
D	LEU774
D	HOH1221

site_id	AD9
Number of Residues	4
Details	binding site for residue ACT D 904

Chain	Residue
D	ARG713
D	LYS720
D	TYR721
D	HOH1165

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN D 905

Chain	Residue
D	GLU699
D	HOH1226
E	GLU452
E	HIS456

site_id	AE2
Number of Residues	13
Details	binding site for residue GLU E 901

Chain	Residue
E	TYR471
E	PRO499
E	LEU500
E	THR501
E	ARG506
E	GLY674
E	SER675
E	THR676
E	GLU726
E	TYR753
E	HOH1014
E	HOH1029
E	HOH1064

site_id	AE3
Number of Residues	20
Details	binding site for residue 8SO E 902

Chain	Residue
E	LYS514
E	PRO515
E	MET517
E	SER518
E	SER750
E	LYS751
E	GLY752
E	VAL771
E	LEU772
E	ASN775
E	GOL905
F	LYS514
F	PRO515
F	MET517
F	SER518
F	SER750
F	LYS751
F	GLY752
F	LEU772
F	ASN775

site_id	AE4
Number of Residues	2
Details	binding site for residue ZN E 903

Chain	Residue
E	HIS433
E	ACT904

site_id	AE5
Number of Residues	4
Details	binding site for residue ACT E 904

Chain	Residue
E	LYS430
E	LYS431
E	HIS433
E	ZN903

site_id	AE6
Number of Residues	10
Details	binding site for residue GOL E 905

Chain	Residue
E	PHE516
E	MET517
E	SER518
E	LEU780
E	ASP781
E	8SO902
E	HOH1001
E	HOH1007
E	HOH1011
F	SER750

site_id	AE7
Number of Residues	13
Details	binding site for residue GLU F 901

Chain	Residue
F	TYR471
F	PRO499
F	LEU500
F	THR501
F	ARG506
F	GLY674
F	SER675
F	THR676
F	GLU726
F	TYR753
F	HOH1018
F	HOH1029
F	HOH1034

site_id	AE8
Number of Residues	5
Details	binding site for residue ZN F 902

Chain	Residue
F	GLU452
F	LYS455
F	HIS456
F	LEU774
F	HOH1007

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0007744\|PDB:2XHD

Chain	Residue	Details
A	PRO499
C	THR501
C	SER675
C	THR676
D	PRO499
D	THR501
D	SER675
D	THR676
E	PRO499
E	THR501
E	SER675
A	THR501
E	THR676
F	PRO499
F	THR501
F	SER675
F	THR676
A	SER675
A	THR676
B	PRO499
B	THR501
B	SER675
B	THR676
C	PRO499

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0000269\|PubMed:21531559, ECO:0007744\|PDB:2XHD, ECO:0007744\|PDB:3R7X

Chain	Residue	Details
A	ARG506
B	ARG506
C	ARG506
D	ARG506
E	ARG506
F	ARG506

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:20614889, ECO:0000269\|PubMed:21531559, ECO:0007744\|PDB:2XHD

Chain	Residue	Details
A	GLU726
B	GLU726
C	GLU726
D	GLU726
E	GLU726
F	GLU726

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000250\|UniProtKB:P19491

Chain	Residue	Details
A	SER683
B	SER683
C	SER683
D	SER683
E	SER683
F	SER683

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000250\|UniProtKB:P19491

Chain	Residue	Details
A	SER717
B	SER717
C	SER717
D	SER717
E	SER717
F	SER717

site_id	SWS_FT_FI6
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN413
B	ASN413
C	ASN413
D	ASN413
E	ASN413
F	ASN413

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)