5Y9M

Crystal structure of CK2a2 form 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000785	cellular_component	chromatin
A	0001669	cellular_component	acrosomal vesicle
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005956	cellular_component	protein kinase CK2 complex
A	0006302	biological_process	double-strand break repair
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0007283	biological_process	spermatogenesis
A	0016055	biological_process	Wnt signaling pathway
A	0021987	biological_process	cerebral cortex development
A	0031519	cellular_component	PcG protein complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0051726	biological_process	regulation of cell cycle
A	0097421	biological_process	liver regeneration
A	0106310	molecular_function	protein serine kinase activity
A	1901524	biological_process	regulation of mitophagy
A	1903955	biological_process	positive regulation of protein targeting to mitochondrion
A	1905818	biological_process	regulation of chromosome separation
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
X	0000785	cellular_component	chromatin
X	0001669	cellular_component	acrosomal vesicle
X	0004672	molecular_function	protein kinase activity
X	0004674	molecular_function	protein serine/threonine kinase activity
X	0005515	molecular_function	protein binding
X	0005524	molecular_function	ATP binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0005956	cellular_component	protein kinase CK2 complex
X	0006302	biological_process	double-strand break repair
X	0006468	biological_process	protein phosphorylation
X	0006915	biological_process	apoptotic process
X	0007283	biological_process	spermatogenesis
X	0016055	biological_process	Wnt signaling pathway
X	0021987	biological_process	cerebral cortex development
X	0031519	cellular_component	PcG protein complex
X	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
X	0051726	biological_process	regulation of cell cycle
X	0097421	biological_process	liver regeneration
X	0106310	molecular_function	protein serine kinase activity
X	1901524	biological_process	regulation of mitophagy
X	1903955	biological_process	positive regulation of protein targeting to mitochondrion
X	1905818	biological_process	regulation of chromosome separation
X	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue NIO X 401

Chain	Residue
X	VAL67
X	LYS69
X	PHE114
X	ILE175
X	ASP176
X	HOH562
X	HOH575

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 X 402

Chain	Residue
X	ARG192
X	HOH543
X	HOH640
X	HOH667
X	HOH707
X	HOH747
X	HOH762
X	HOH773
A	LYS199
A	ASN239

---

site_id	AC3
Number of Residues	9
Details	binding site for residue SO4 X 403

Chain	Residue
X	ARG307
X	TYR308
X	ASP309
X	HOH609
X	HOH624
X	HOH678
X	HOH703
X	HOH732
X	HOH790

---

site_id	AC4
Number of Residues	8
Details	binding site for residue SO4 X 404

Chain	Residue
X	LYS78
X	ARG81
X	ARG156
X	ASN190
X	HOH524
X	HOH651
X	HOH771
X	HOH776

---

site_id	AC5
Number of Residues	7
Details	binding site for residue NIO A 401

Chain	Residue
A	VAL67
A	LYS69
A	PHE114
A	ILE175
A	ASP176
A	HOH549
A	HOH628

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 402

Chain	Residue
A	LYS78
A	ARG81
A	ARG156
A	ASN190
A	HOH516
A	HOH610
A	HOH698

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnner..........VVVK

Chain	Residue	Details
X	LEU46-LYS69

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
X	ILE153-ILE165

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
X	ASP157
A	ASP157

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
X	LEU46
X	LYS69
A	LEU46
A	LYS69

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	TYR13
A	TYR13

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163

Chain	Residue	Details
X	SER18
A	SER18

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195

Chain	Residue	Details
X	SER21
X	SER288
A	SER21
A	SER288

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
X	LYS97
A	LYS97

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