5Y58

Crystal structure of Ku70/80 and TLC1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000725	biological_process	recombinational repair
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0003690	molecular_function	double-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0006281	biological_process	DNA repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006310	biological_process	DNA recombination
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030466	biological_process	silent mating-type cassette heterochromatin formation
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0042162	molecular_function	telomeric DNA binding
A	0043564	cellular_component	Ku70:Ku80 complex
A	0070034	molecular_function	telomerase RNA binding
A	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
A	0097695	biological_process	establishment of protein-containing complex localization to telomere
B	0000166	molecular_function	nucleotide binding
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000725	biological_process	recombinational repair
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0003690	molecular_function	double-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0006281	biological_process	DNA repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006310	biological_process	DNA recombination
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0007535	biological_process	donor selection
B	0016787	molecular_function	hydrolase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0031509	biological_process	subtelomeric heterochromatin formation
B	0034502	biological_process	protein localization to chromosome
B	0042162	molecular_function	telomeric DNA binding
B	0043564	cellular_component	Ku70:Ku80 complex
B	0070034	molecular_function	telomerase RNA binding
B	0097695	biological_process	establishment of protein-containing complex localization to telomere
C	0000166	molecular_function	nucleotide binding
C	0000723	biological_process	telomere maintenance
C	0000724	biological_process	double-strand break repair via homologous recombination
C	0000725	biological_process	recombinational repair
C	0000727	biological_process	double-strand break repair via break-induced replication
C	0000781	cellular_component	chromosome, telomeric region
C	0003677	molecular_function	DNA binding
C	0003678	molecular_function	DNA helicase activity
C	0003684	molecular_function	damaged DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0006281	biological_process	DNA repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006310	biological_process	DNA recombination
C	0006325	biological_process	chromatin organization
C	0006974	biological_process	DNA damage response
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030466	biological_process	silent mating-type cassette heterochromatin formation
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0042162	molecular_function	telomeric DNA binding
C	0043564	cellular_component	Ku70:Ku80 complex
C	0070034	molecular_function	telomerase RNA binding
C	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
C	0097695	biological_process	establishment of protein-containing complex localization to telomere
D	0000166	molecular_function	nucleotide binding
D	0000723	biological_process	telomere maintenance
D	0000724	biological_process	double-strand break repair via homologous recombination
D	0000725	biological_process	recombinational repair
D	0000781	cellular_component	chromosome, telomeric region
D	0003677	molecular_function	DNA binding
D	0003678	molecular_function	DNA helicase activity
D	0003684	molecular_function	damaged DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0006281	biological_process	DNA repair
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006310	biological_process	DNA recombination
D	0006325	biological_process	chromatin organization
D	0006974	biological_process	DNA damage response
D	0007535	biological_process	donor selection
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0031509	biological_process	subtelomeric heterochromatin formation
D	0034502	biological_process	protein localization to chromosome
D	0042162	molecular_function	telomeric DNA binding
D	0043564	cellular_component	Ku70:Ku80 complex
D	0070034	molecular_function	telomerase RNA binding
D	0097695	biological_process	establishment of protein-containing complex localization to telomere
E	0000166	molecular_function	nucleotide binding
E	0000723	biological_process	telomere maintenance
E	0000724	biological_process	double-strand break repair via homologous recombination
E	0000725	biological_process	recombinational repair
E	0000727	biological_process	double-strand break repair via break-induced replication
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0003678	molecular_function	DNA helicase activity
E	0003684	molecular_function	damaged DNA binding
E	0003690	molecular_function	double-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0006281	biological_process	DNA repair
E	0006303	biological_process	double-strand break repair via nonhomologous end joining
E	0006310	biological_process	DNA recombination
E	0006325	biological_process	chromatin organization
E	0006974	biological_process	DNA damage response
E	0016787	molecular_function	hydrolase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0030466	biological_process	silent mating-type cassette heterochromatin formation
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0042162	molecular_function	telomeric DNA binding
E	0043564	cellular_component	Ku70:Ku80 complex
E	0070034	molecular_function	telomerase RNA binding
E	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
E	0097695	biological_process	establishment of protein-containing complex localization to telomere
F	0000166	molecular_function	nucleotide binding
F	0000723	biological_process	telomere maintenance
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000725	biological_process	recombinational repair
F	0000781	cellular_component	chromosome, telomeric region
F	0003677	molecular_function	DNA binding
F	0003678	molecular_function	DNA helicase activity
F	0003684	molecular_function	damaged DNA binding
F	0003690	molecular_function	double-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0006281	biological_process	DNA repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006310	biological_process	DNA recombination
F	0006325	biological_process	chromatin organization
F	0006974	biological_process	DNA damage response
F	0007535	biological_process	donor selection
F	0016787	molecular_function	hydrolase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0031509	biological_process	subtelomeric heterochromatin formation
F	0034502	biological_process	protein localization to chromosome
F	0042162	molecular_function	telomeric DNA binding
F	0043564	cellular_component	Ku70:Ku80 complex
F	0070034	molecular_function	telomerase RNA binding
F	0097695	biological_process	establishment of protein-containing complex localization to telomere

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	645
Details	Domain: {"description":"Ku"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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