5Y4Z

Crystal structure of the Zika virus NS3 helicase complex with AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ANP A 701

Chain	Residue
A	PRO196
A	ASN330
A	ARG459
A	ARG462
A	MN702
A	HOH829
A	HOH830
A	HOH987
A	HOH1039
A	GLY197
A	ALA198
A	GLY199
A	LYS200
A	THR201
A	ARG202
A	GLU286
A	ALA317

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site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 702

Chain	Residue
A	THR201
A	GLU286
A	ANP701
A	HOH830
A	HOH863

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU194

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG456
A	ARG459

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P06935

Chain	Residue	Details
A	ARG617

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000269|PubMed:37478852

Chain	Residue	Details
A	LYS389

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