5Y4R
Structure of a methyltransferase complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008276 | molecular_function | protein methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0008983 | molecular_function | protein-glutamate O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008276 | molecular_function | protein methyltransferase activity |
| B | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| B | 0008983 | molecular_function | protein-glutamate O-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0035438 | molecular_function | cyclic-di-GMP binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0035438 | molecular_function | cyclic-di-GMP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | ARG191 |
| A | GLU195 |
| A | PHE196 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS154 |
| A | PHE196 |
| A | ALA198 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | ASP258 |
| A | HIS259 |
| C | ARG60 |
| A | ARG229 |
| A | LEU256 |
| A | PRO257 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 304 |
| Chain | Residue |
| A | ARG58 |
| A | GLY59 |
| A | GLY60 |
| A | LEU61 |
| A | ARG62 |
| A | GLU63 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | VAL263 |
| A | ARG272 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue C2E D 201 |
| Chain | Residue |
| B | LYS135 |
| C | ARG79 |
| C | C2E201 |
| C | C2E202 |
| C | HOH315 |
| D | GLU7 |
| D | ARG8 |
| D | ARG9 |
| D | ARG13 |
| D | TRP77 |
| D | ARG79 |
| D | C2E202 |
| D | HOH309 |
| D | HOH316 |
| D | HOH320 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue C2E D 202 |
| Chain | Residue |
| D | ARG8 |
| D | ARG9 |
| D | ARG10 |
| D | PHE11 |
| D | ARG13 |
| D | ASP35 |
| D | VAL36 |
| D | SER37 |
| D | HIS39 |
| D | GLY40 |
| D | ILE41 |
| D | LEU42 |
| D | TRP77 |
| D | PHE85 |
| D | GLU86 |
| D | C2E201 |
| D | HOH306 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| B | ARG191 |
| B | VAL194 |
| B | GLU195 |
| B | PHE196 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | LYS154 |
| B | PHE196 |
| B | ALA198 |
| B | HOH429 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | ARG229 |
| B | ASN255 |
| B | LEU256 |
| B | PRO257 |
| B | ASP258 |
| B | HIS259 |
| B | HOH406 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | ARG234 |
| B | GLY237 |
| B | SO4305 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 305 |
| Chain | Residue |
| B | SER204 |
| B | TYR205 |
| B | ARG234 |
| B | SO4304 |
| B | HOH401 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 306 |
| Chain | Residue |
| B | ARG12 |
| B | GLY24 |
| B | SER25 |
| B | ASN26 |
| B | LYS27 |
| B | GLN28 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 307 |
| Chain | Residue |
| B | ARG272 |
| site_id | AD6 |
| Number of Residues | 19 |
| Details | binding site for residue C2E C 201 |
| Chain | Residue |
| C | HOH307 |
| D | C2E201 |
| C | ARG8 |
| C | ARG9 |
| C | ARG10 |
| C | ARG13 |
| C | ASP35 |
| C | VAL36 |
| C | SER37 |
| C | HIS39 |
| C | GLY40 |
| C | ILE41 |
| C | LEU42 |
| C | TRP77 |
| C | PHE85 |
| C | GLU86 |
| C | C2E202 |
| C | HOH303 |
| C | HOH306 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue C2E C 202 |
| Chain | Residue |
| B | LEU131 |
| B | GLY132 |
| B | LYS135 |
| C | GLU7 |
| C | ARG8 |
| C | ARG9 |
| C | ARG13 |
| C | TRP77 |
| C | ARG79 |
| C | C2E201 |
| C | HOH301 |
| C | HOH310 |
| C | HOH315 |
| D | C2E201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 192 |
| Details | Domain: {"description":"PilZ","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"RXXXR motif; surrounds the surface of the c-di-GMP binding site","evidences":[{"source":"PubMed","id":"21280119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Motif: {"description":"DXSXXG motif; surrounds the surface of the c-di-GMP binding site","evidences":[{"source":"PubMed","id":"21280119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21310957","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for c-di-GMP binding"} |
| Chain | Residue | Details |
