5Y20

Crystal structure of AL1 PHD finger bound to H3K4me3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006355	biological_process	regulation of DNA-templated transcription
A	0042393	molecular_function	histone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 101

Chain	Residue
A	CYS7
A	CYS10
A	HIS31
A	CYS34

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 102

Chain	Residue
A	CYS23
A	CYS26
A	CYS50
A	CYS53

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site_id	AC3
Number of Residues	13
Details	binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3

Chain	Residue
A	CYS10
A	ASN13
A	TYR14
A	PHE19
A	TRP20
A	TRP29
A	HOH213
P	THR3
P	THR6
P	ALA7
P	HOH101
P	HOH104
A	THR5

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Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	47
Details	ZF_PHD_1 Zinc finger PHD-type signature. CgsCggnytndefw...................................IcCdv..Cerw.YHgkCvkitpakaesikq................................YkCpsC

Chain	Residue	Details
A	CYS7-CYS53

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
P	ARG2
A	TRP20
A	ASP24
A	TRP29

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088

Chain	Residue	Details
P	THR3

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	M3L4

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
P	GLN5

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
P	THR6

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