5Y1Z

Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
B	0003779	molecular_function	actin binding
C	0006355	biological_process	regulation of DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 201

Chain	Residue
A	PRO91
A	ASP92
C	LYS233

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	CYS91
C	CYS94
C	HIS111
C	CYS114

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 502

Chain	Residue
C	CYS274
C	HIS278
C	CYS255
C	CYS258

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 503

Chain	Residue
C	CYS103
C	CYS106
C	CYS127
C	CYS130

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 C 504

Chain	Residue
C	ARG354
C	TYR362
C	SO4505
C	HOH608

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 C 505

Chain	Residue
C	ARG354
C	SO4504
D	ARG96

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 C 506

Chain	Residue
C	LYS284
C	GLY287

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	CYS103
D	CYS106
D	CYS127
D	CYS130

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN D 502

Chain	Residue
D	CYS91
D	CYS94
D	HIS111
D	CYS114

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN D 503

Chain	Residue
D	CYS255
D	CYS258
D	CYS274
D	HIS278

---

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 D 504

Chain	Residue
D	ASN250
D	ARG297
D	ARG313
D	TRP315

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 D 505

Chain	Residue
D	LYS299
D	ASP300
D	TRP315

---

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL D 506

Chain	Residue
C	ARG355
D	GLN99
D	HOH623
D	HOH624

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	40
Details	ZF_PHD_1 Zinc finger PHD-type signature. CwvChregqv.......................................LcCel..Cprv.YHakClrltsepegd...................................WfCpeC

Chain	Residue	Details
C	CYS91-CYS130

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	ZN_FING: PHD-type => ECO:0000255|PROSITE-ProRule:PRU00146

Chain	Residue	Details
C	ASP88-ILE133
D	ASP88-ILE133

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	BINDING: BINDING => ECO:0000269|PubMed:28966017, ECO:0007744|PDB:5Y1Z

Chain	Residue	Details
C	CYS91
C	CYS258
C	CYS274
D	CYS91
D	CYS94
D	CYS103
D	CYS106
D	HIS111
D	CYS114
D	CYS127
D	CYS130
C	CYS94
D	CYS255
D	CYS258
D	CYS274
C	CYS103
C	CYS106
C	HIS111
C	CYS114
C	CYS127
C	CYS130
C	CYS255

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	THR404
D	THR404

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER406
D	SER406

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS390
D	LYS390

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