5Y1Z
Crystal structure of ZMYND8 PHD-BROMO-PWWP tandem in complex with Drebrin ADF-H domain
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | PRO91 |
| A | ASP92 |
| C | LYS233 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | CYS91 |
| C | CYS94 |
| C | HIS111 |
| C | CYS114 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 502 |
| Chain | Residue |
| C | CYS274 |
| C | HIS278 |
| C | CYS255 |
| C | CYS258 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 503 |
| Chain | Residue |
| C | CYS103 |
| C | CYS106 |
| C | CYS127 |
| C | CYS130 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 504 |
| Chain | Residue |
| C | ARG354 |
| C | TYR362 |
| C | SO4505 |
| C | HOH608 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 505 |
| Chain | Residue |
| C | ARG354 |
| C | SO4504 |
| D | ARG96 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 506 |
| Chain | Residue |
| C | LYS284 |
| C | GLY287 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | CYS103 |
| D | CYS106 |
| D | CYS127 |
| D | CYS130 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 502 |
| Chain | Residue |
| D | CYS91 |
| D | CYS94 |
| D | HIS111 |
| D | CYS114 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 503 |
| Chain | Residue |
| D | CYS255 |
| D | CYS258 |
| D | CYS274 |
| D | HIS278 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 504 |
| Chain | Residue |
| D | ASN250 |
| D | ARG297 |
| D | ARG313 |
| D | TRP315 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 505 |
| Chain | Residue |
| D | LYS299 |
| D | ASP300 |
| D | TRP315 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 506 |
| Chain | Residue |
| C | ARG355 |
| D | GLN99 |
| D | HOH623 |
| D | HOH624 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 40 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CwvChregqv.......................................LcCel..Cprv.YHakClrltsepegd...................................WfCpeC |
| Chain | Residue | Details |
| C | CYS91-CYS130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Dozynkiewicz M.","Norman J.C."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 214 |
| Details | Domain: {"description":"Bromo","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 100 |
| Details | Domain: {"description":"PWWP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00162","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 90 |
| Details | Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 478 |
| Details | Region: {"description":"Required for interaction with histone H3 and histone H4","evidences":[{"source":"PubMed","id":"25593309","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28966017","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y1Z","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
