5XVU
Crystal structure of the protein kinase CK2 catalytic domain from Plasmodium falciparum bound to ATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018105 | biological_process | peptidyl-serine phosphorylation |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0046777 | biological_process | protein autophosphorylation |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005956 | cellular_component | protein kinase CK2 complex |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018105 | biological_process | peptidyl-serine phosphorylation |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0046777 | biological_process | protein autophosphorylation |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0106310 | molecular_function | protein serine kinase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004674 | molecular_function | protein serine/threonine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005956 | cellular_component | protein kinase CK2 complex |
| C | 0006468 | biological_process | protein phosphorylation |
| C | 0006974 | biological_process | DNA damage response |
| C | 0016301 | molecular_function | kinase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0018105 | biological_process | peptidyl-serine phosphorylation |
| C | 0019901 | molecular_function | protein kinase binding |
| C | 0046777 | biological_process | protein autophosphorylation |
| C | 0051726 | biological_process | regulation of cell cycle |
| C | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | ARG84 |
| A | ARG159 |
| A | ASN193 |
| A | HOH506 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 402 |
| Chain | Residue |
| A | ARG199 |
| A | ASN242 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue ATP A 403 |
| Chain | Residue |
| A | TYR54 |
| A | SER55 |
| A | VAL57 |
| A | ALA70 |
| A | LYS72 |
| A | LYS81 |
| A | ILE99 |
| A | GLU118 |
| A | ILE120 |
| A | HIS164 |
| A | SER179 |
| B | GLU64 |
| A | ILE49 |
| A | GLY50 |
| A | LYS53 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | ASP29 |
| A | TYR30 |
| A | ASP31 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | MET323 |
| A | GLU324 |
| A | HIS325 |
| A | PHE328 |
| A | GLU330 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | LYS81 |
| B | ARG84 |
| B | ARG159 |
| B | ASN193 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| A | ARG51 |
| B | ASN38 |
| B | LYS39 |
| B | HOH508 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | ARG199 |
| B | ASN242 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue ATP B 404 |
| Chain | Residue |
| B | ILE49 |
| B | GLY50 |
| B | GLY52 |
| B | LYS53 |
| B | TYR54 |
| B | SER55 |
| B | VAL57 |
| B | ALA70 |
| B | LYS72 |
| B | ILE99 |
| B | GLU118 |
| B | ILE120 |
| B | SER179 |
| B | HOH502 |
| B | HOH507 |
| C | GLU64 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | LEU33 |
| B | TRP37 |
| B | LYS83 |
| B | LYS106 |
| B | HOH514 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| B | ARG51 |
| C | ASN38 |
| C | LYS39 |
| C | HOH507 |
| C | HOH514 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| C | LYS81 |
| C | ARG84 |
| C | ARG159 |
| C | ASN193 |
| C | HOH503 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 403 |
| Chain | Residue |
| C | ARG199 |
| C | ASN242 |
| C | HOH534 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 404 |
| Chain | Residue |
| A | ARG42 |
| C | LYS48 |
| C | ARG51 |
| C | HOH505 |
| site_id | AD6 |
| Number of Residues | 13 |
| Details | binding site for residue ATP C 405 |
| Chain | Residue |
| C | ILE49 |
| C | GLY52 |
| C | LYS53 |
| C | TYR54 |
| C | SER55 |
| C | VAL57 |
| C | ALA70 |
| C | LYS72 |
| C | ILE99 |
| C | GLU118 |
| C | ILE120 |
| C | ILE178 |
| C | SER179 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 406 |
| Chain | Residue |
| C | GLY95 |
| C | ASN97 |
| C | ILE98 |
| C | ARG176 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGKYSEVFnGydtecnrp..........CAIK |
| Chain | Residue | Details |
| A | ILE49-LYS72 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNIMI |
| Chain | Residue | Details |
| A | ILE156-ILE168 |
