Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XTH

Cryo-EM structure of human respiratory supercomplex I1III2IV1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
0	0045277	cellular_component	respiratory chain complex IV
1	0005743	cellular_component	mitochondrial inner membrane
1	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
1	0045277	cellular_component	respiratory chain complex IV
2	0005740	cellular_component	mitochondrial envelope
2	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
2	0045277	cellular_component	respiratory chain complex IV
3	0005743	cellular_component	mitochondrial inner membrane
4	0005739	cellular_component	mitochondrion
4	0045277	cellular_component	respiratory chain complex IV
5	0005743	cellular_component	mitochondrial inner membrane
5	0006119	biological_process	oxidative phosphorylation
5	0016020	cellular_component	membrane
5	0045277	cellular_component	respiratory chain complex IV
6	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
6	0045277	cellular_component	respiratory chain complex IV
7	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
8	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
8	0045277	cellular_component	respiratory chain complex IV
9	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
9	0045277	cellular_component	respiratory chain complex IV
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0009060	biological_process	aerobic respiration
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0022904	biological_process	respiratory electron transport chain
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0045271	cellular_component	respiratory chain complex I
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	1902600	biological_process	proton transmembrane transport
AA	0005739	cellular_component	mitochondrion
AA	0005743	cellular_component	mitochondrial inner membrane
AA	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AA	0016020	cellular_component	membrane
AA	0021539	biological_process	subthalamus development
AA	0021548	biological_process	pons development
AA	0021680	biological_process	cerebellar Purkinje cell layer development
AA	0021766	biological_process	hippocampus development
AA	0021794	biological_process	thalamus development
AA	0021854	biological_process	hypothalamus development
AA	0021860	biological_process	pyramidal neuron development
AA	0022904	biological_process	respiratory electron transport chain
AA	0030901	biological_process	midbrain development
AA	0045275	cellular_component	respiratory chain complex III
AA	0045333	biological_process	cellular respiration
AB	0008121	molecular_function	quinol-cytochrome-c reductase activity
AC	0008121	molecular_function	quinol-cytochrome-c reductase activity
AC	0016020	cellular_component	membrane
AC	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AD	0005515	molecular_function	protein binding
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AD	0008121	molecular_function	quinol-cytochrome-c reductase activity
AD	0016020	cellular_component	membrane
AD	0022904	biological_process	respiratory electron transport chain
AD	0045275	cellular_component	respiratory chain complex III
AD	0045333	biological_process	cellular respiration
AD	1902600	biological_process	proton transmembrane transport
AE	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0005515	molecular_function	protein binding
AF	0005739	cellular_component	mitochondrion
AF	0005743	cellular_component	mitochondrial inner membrane
AF	0006119	biological_process	oxidative phosphorylation
AF	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0009060	biological_process	aerobic respiration
AF	0016020	cellular_component	membrane
AF	0022904	biological_process	respiratory electron transport chain
AF	0045275	cellular_component	respiratory chain complex III
AF	0045333	biological_process	cellular respiration
AF	0098803	cellular_component	respiratory chain complex
AG	0005739	cellular_component	mitochondrion
AG	0005743	cellular_component	mitochondrial inner membrane
AG	0006091	biological_process	generation of precursor metabolites and energy
AG	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AG	0009055	molecular_function	electron transfer activity
AG	0022904	biological_process	respiratory electron transport chain
AG	0045275	cellular_component	respiratory chain complex III
AG	0045333	biological_process	cellular respiration
AH	0009055	molecular_function	electron transfer activity
AH	0020037	molecular_function	heme binding
AJ	0001666	biological_process	response to hypoxia
AJ	0005739	cellular_component	mitochondrion
AJ	0005743	cellular_component	mitochondrial inner membrane
AJ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AJ	0007584	biological_process	response to nutrient
AJ	0008121	molecular_function	quinol-cytochrome-c reductase activity
AJ	0009055	molecular_function	electron transfer activity
AJ	0009410	biological_process	response to xenobiotic stimulus
AJ	0009636	biological_process	response to toxic substance
AJ	0009725	biological_process	response to hormone
AJ	0015990	biological_process	electron transport coupled proton transport
AJ	0016020	cellular_component	membrane
AJ	0016491	molecular_function	oxidoreductase activity
AJ	0022904	biological_process	respiratory electron transport chain
AJ	0031100	biological_process	animal organ regeneration
AJ	0032991	cellular_component	protein-containing complex
AJ	0033590	biological_process	response to cobalamin
AJ	0033762	biological_process	response to glucagon
AJ	0044877	molecular_function	protein-containing complex binding
AJ	0045275	cellular_component	respiratory chain complex III
AJ	0045333	biological_process	cellular respiration
AJ	0045471	biological_process	response to ethanol
AJ	0046686	biological_process	response to cadmium ion
AJ	0046688	biological_process	response to copper ion
AJ	0046689	biological_process	response to mercury ion
AJ	0046872	molecular_function	metal ion binding
AJ	0051592	biological_process	response to calcium ion
AJ	0055093	biological_process	response to hyperoxia
AJ	1904421	biological_process	response to D-galactosamine
AK	0004222	molecular_function	metalloendopeptidase activity
AK	0005515	molecular_function	protein binding
AK	0005739	cellular_component	mitochondrion
AK	0005743	cellular_component	mitochondrial inner membrane
AK	0006119	biological_process	oxidative phosphorylation
AK	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AK	0006508	biological_process	proteolysis
AK	0009060	biological_process	aerobic respiration
AK	0022904	biological_process	respiratory electron transport chain
AK	0045275	cellular_component	respiratory chain complex III
AK	0045333	biological_process	cellular respiration
AK	0046872	molecular_function	metal ion binding
AL	0005515	molecular_function	protein binding
AL	0005739	cellular_component	mitochondrion
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0006119	biological_process	oxidative phosphorylation
AL	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AL	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
AL	0008121	molecular_function	quinol-cytochrome-c reductase activity
AL	0009060	biological_process	aerobic respiration
AL	0014823	biological_process	response to activity
AL	0016020	cellular_component	membrane
AL	0017087	cellular_component	mitochondrial processing peptidase complex
AL	0022904	biological_process	respiratory electron transport chain
AL	0031625	molecular_function	ubiquitin protein ligase binding
AL	0043279	biological_process	response to alkaloid
AL	0044877	molecular_function	protein-containing complex binding
AL	0045275	cellular_component	respiratory chain complex III
AL	0045333	biological_process	cellular respiration
AL	0046872	molecular_function	metal ion binding
AL	0098803	cellular_component	respiratory chain complex
AL	1902600	biological_process	proton transmembrane transport
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AN	0016020	cellular_component	membrane
AN	0021539	biological_process	subthalamus development
AN	0021548	biological_process	pons development
AN	0021680	biological_process	cerebellar Purkinje cell layer development
AN	0021766	biological_process	hippocampus development
AN	0021794	biological_process	thalamus development
AN	0021854	biological_process	hypothalamus development
AN	0021860	biological_process	pyramidal neuron development
AN	0022904	biological_process	respiratory electron transport chain
AN	0030901	biological_process	midbrain development
AN	0045275	cellular_component	respiratory chain complex III
AN	0045333	biological_process	cellular respiration
AO	0008121	molecular_function	quinol-cytochrome-c reductase activity
AP	0008121	molecular_function	quinol-cytochrome-c reductase activity
AP	0016020	cellular_component	membrane
AP	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AQ	0005515	molecular_function	protein binding
AQ	0005739	cellular_component	mitochondrion
AQ	0005743	cellular_component	mitochondrial inner membrane
AQ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AQ	0008121	molecular_function	quinol-cytochrome-c reductase activity
AQ	0016020	cellular_component	membrane
AQ	0022904	biological_process	respiratory electron transport chain
AQ	0045275	cellular_component	respiratory chain complex III
AQ	0045333	biological_process	cellular respiration
AQ	1902600	biological_process	proton transmembrane transport
AR	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0005515	molecular_function	protein binding
AS	0005739	cellular_component	mitochondrion
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0006119	biological_process	oxidative phosphorylation
AS	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0009060	biological_process	aerobic respiration
AS	0016020	cellular_component	membrane
AS	0022904	biological_process	respiratory electron transport chain
AS	0045275	cellular_component	respiratory chain complex III
AS	0045333	biological_process	cellular respiration
AS	0098803	cellular_component	respiratory chain complex
AT	0005739	cellular_component	mitochondrion
AT	0005743	cellular_component	mitochondrial inner membrane
AT	0006091	biological_process	generation of precursor metabolites and energy
AT	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AT	0009055	molecular_function	electron transfer activity
AT	0022904	biological_process	respiratory electron transport chain
AT	0045275	cellular_component	respiratory chain complex III
AT	0045333	biological_process	cellular respiration
AU	0009055	molecular_function	electron transfer activity
AU	0020037	molecular_function	heme binding
AV	0001666	biological_process	response to hypoxia
AV	0005739	cellular_component	mitochondrion
AV	0005743	cellular_component	mitochondrial inner membrane
AV	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AV	0007584	biological_process	response to nutrient
AV	0008121	molecular_function	quinol-cytochrome-c reductase activity
AV	0009055	molecular_function	electron transfer activity
AV	0009410	biological_process	response to xenobiotic stimulus
AV	0009636	biological_process	response to toxic substance
AV	0009725	biological_process	response to hormone
AV	0015990	biological_process	electron transport coupled proton transport
AV	0016020	cellular_component	membrane
AV	0016491	molecular_function	oxidoreductase activity
AV	0022904	biological_process	respiratory electron transport chain
AV	0031100	biological_process	animal organ regeneration
AV	0032991	cellular_component	protein-containing complex
AV	0033590	biological_process	response to cobalamin
AV	0033762	biological_process	response to glucagon
AV	0044877	molecular_function	protein-containing complex binding
AV	0045275	cellular_component	respiratory chain complex III
AV	0045333	biological_process	cellular respiration
AV	0045471	biological_process	response to ethanol
AV	0046686	biological_process	response to cadmium ion
AV	0046688	biological_process	response to copper ion
AV	0046689	biological_process	response to mercury ion
AV	0046872	molecular_function	metal ion binding
AV	0051592	biological_process	response to calcium ion
AV	0055093	biological_process	response to hyperoxia
AV	1904421	biological_process	response to D-galactosamine
AW	0004222	molecular_function	metalloendopeptidase activity
AW	0005515	molecular_function	protein binding
AW	0005739	cellular_component	mitochondrion
AW	0005743	cellular_component	mitochondrial inner membrane
AW	0006119	biological_process	oxidative phosphorylation
AW	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AW	0006508	biological_process	proteolysis
AW	0009060	biological_process	aerobic respiration
AW	0022904	biological_process	respiratory electron transport chain
AW	0045275	cellular_component	respiratory chain complex III
AW	0045333	biological_process	cellular respiration
AW	0046872	molecular_function	metal ion binding
AY	0005515	molecular_function	protein binding
AY	0005739	cellular_component	mitochondrion
AY	0005743	cellular_component	mitochondrial inner membrane
AY	0006119	biological_process	oxidative phosphorylation
AY	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AY	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
AY	0008121	molecular_function	quinol-cytochrome-c reductase activity
AY	0009060	biological_process	aerobic respiration
AY	0014823	biological_process	response to activity
AY	0016020	cellular_component	membrane
AY	0017087	cellular_component	mitochondrial processing peptidase complex
AY	0022904	biological_process	respiratory electron transport chain
AY	0031625	molecular_function	ubiquitin protein ligase binding
AY	0043279	biological_process	response to alkaloid
AY	0044877	molecular_function	protein-containing complex binding
AY	0045275	cellular_component	respiratory chain complex III
AY	0045333	biological_process	cellular respiration
AY	0046872	molecular_function	metal ion binding
AY	0098803	cellular_component	respiratory chain complex
AY	1902600	biological_process	proton transmembrane transport
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
b	0009060	biological_process	aerobic respiration
b	0022904	biological_process	respiratory electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0045271	cellular_component	respiratory chain complex I
b	1902600	biological_process	proton transmembrane transport
B	0016020	cellular_component	membrane
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
c	0005739	cellular_component	mitochondrion
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0048038	molecular_function	quinone binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
d	0005515	molecular_function	protein binding
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
d	0009060	biological_process	aerobic respiration
d	0022904	biological_process	respiratory electron transport chain
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0045271	cellular_component	respiratory chain complex I
d	1902600	biological_process	proton transmembrane transport
E	0045271	cellular_component	respiratory chain complex I
f	0005739	cellular_component	mitochondrion
f	0045271	cellular_component	respiratory chain complex I
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005886	cellular_component	plasma membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
g	0009060	biological_process	aerobic respiration
g	0010918	biological_process	positive regulation of mitochondrial membrane potential
g	0022904	biological_process	respiratory electron transport chain
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0035577	cellular_component	azurophil granule membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0045271	cellular_component	respiratory chain complex I
g	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction
g	1902600	biological_process	proton transmembrane transport
g	1903427	biological_process	negative regulation of reactive oxygen species biosynthetic process
g	2001171	biological_process	positive regulation of ATP biosynthetic process
G	0006633	biological_process	fatty acid biosynthetic process
h	0005515	molecular_function	protein binding
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005758	cellular_component	mitochondrial intermembrane space
h	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
h	0009060	biological_process	aerobic respiration
h	0022904	biological_process	respiratory electron transport chain
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0045271	cellular_component	respiratory chain complex I
h	1902600	biological_process	proton transmembrane transport
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0022904	biological_process	respiratory electron transport chain
H	0032991	cellular_component	protein-containing complex
H	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
H	0045271	cellular_component	respiratory chain complex I
H	1902600	biological_process	proton transmembrane transport
i	0001666	biological_process	response to hypoxia
i	0005515	molecular_function	protein binding
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0009060	biological_process	aerobic respiration
i	0019901	molecular_function	protein kinase binding
i	0022904	biological_process	respiratory electron transport chain
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0035255	molecular_function	ionotropic glutamate receptor binding
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0045271	cellular_component	respiratory chain complex I
i	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0022904	biological_process	respiratory electron transport chain
I	0042773	biological_process	ATP synthesis coupled electron transport
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0045271	cellular_component	respiratory chain complex I
I	1902600	biological_process	proton transmembrane transport
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0022904	biological_process	respiratory electron transport chain
j	0031966	cellular_component	mitochondrial membrane
j	1902600	biological_process	proton transmembrane transport
k	0005743	cellular_component	mitochondrial inner membrane
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0022904	biological_process	respiratory electron transport chain
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0045271	cellular_component	respiratory chain complex I
k	1902600	biological_process	proton transmembrane transport
K	0005739	cellular_component	mitochondrion
K	0045271	cellular_component	respiratory chain complex I
l	0001666	biological_process	response to hypoxia
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0009060	biological_process	aerobic respiration
l	0015990	biological_process	electron transport coupled proton transport
l	0022904	biological_process	respiratory electron transport chain
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042542	biological_process	response to hydrogen peroxide
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0045271	cellular_component	respiratory chain complex I
L	0022900	biological_process	electron transport chain
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0009055	molecular_function	electron transfer activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0022904	biological_process	respiratory electron transport chain
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045271	cellular_component	respiratory chain complex I
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	1902600	biological_process	proton transmembrane transport
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0009060	biological_process	aerobic respiration
n	0022904	biological_process	respiratory electron transport chain
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0045271	cellular_component	respiratory chain complex I
n	1902600	biological_process	proton transmembrane transport
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0022904	biological_process	respiratory electron transport chain
N	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0045271	cellular_component	respiratory chain complex I
N	1902600	biological_process	proton transmembrane transport
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0022904	biological_process	respiratory electron transport chain
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0045271	cellular_component	respiratory chain complex I
o	1902600	biological_process	proton transmembrane transport
O	0016491	molecular_function	oxidoreductase activity
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0007605	biological_process	sensory perception of sound
p	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
p	0009060	biological_process	aerobic respiration
p	0022904	biological_process	respiratory electron transport chain
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0045271	cellular_component	respiratory chain complex I
p	1902600	biological_process	proton transmembrane transport
P	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005759	cellular_component	mitochondrial matrix
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009055	molecular_function	electron transfer activity
Q	0009060	biological_process	aerobic respiration
Q	0016491	molecular_function	oxidoreductase activity
Q	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0022904	biological_process	respiratory electron transport chain
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0045271	cellular_component	respiratory chain complex I
Q	0046872	molecular_function	metal ion binding
Q	0048038	molecular_function	quinone binding
Q	0051287	molecular_function	NAD binding
Q	0051536	molecular_function	iron-sulfur cluster binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0061351	biological_process	neural precursor cell proliferation
Q	0071453	biological_process	cellular response to oxygen levels
Q	1902600	biological_process	proton transmembrane transport
r	0001666	biological_process	response to hypoxia
r	0001701	biological_process	in utero embryonic development
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0021549	biological_process	cerebellum development
r	0022904	biological_process	respiratory electron transport chain
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0035094	biological_process	response to nicotine
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
r	0045471	biological_process	response to ethanol
r	0048039	molecular_function	ubiquinone binding
s	0005743	cellular_component	mitochondrial inner membrane
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0016020	cellular_component	membrane
s	0022904	biological_process	respiratory electron transport chain
s	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0022904	biological_process	respiratory electron transport chain
S	0031966	cellular_component	mitochondrial membrane
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0045271	cellular_component	respiratory chain complex I
S	1902600	biological_process	proton transmembrane transport
T	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0005515	molecular_function	protein binding
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005758	cellular_component	mitochondrial intermembrane space
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
u	0009060	biological_process	aerobic respiration
u	0022904	biological_process	respiratory electron transport chain
u	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
u	0044877	molecular_function	protein-containing complex binding
u	0045271	cellular_component	respiratory chain complex I
u	1902600	biological_process	proton transmembrane transport
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009060	biological_process	aerobic respiration
U	0022904	biological_process	respiratory electron transport chain
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0045271	cellular_component	respiratory chain complex I
U	1902600	biological_process	proton transmembrane transport
v	0005739	cellular_component	mitochondrion
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
V	0009060	biological_process	aerobic respiration
V	0022904	biological_process	respiratory electron transport chain
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0045271	cellular_component	respiratory chain complex I
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
w	0009060	biological_process	aerobic respiration
w	0022904	biological_process	respiratory electron transport chain
w	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
w	0045271	cellular_component	respiratory chain complex I
w	1902600	biological_process	proton transmembrane transport
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006915	biological_process	apoptotic process
W	0009060	biological_process	aerobic respiration
W	0022904	biological_process	respiratory electron transport chain
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0035458	biological_process	cellular response to interferon-beta
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045039	biological_process	protein insertion into mitochondrial inner membrane
W	0045271	cellular_component	respiratory chain complex I
W	0045732	biological_process	positive regulation of protein catabolic process
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0061133	molecular_function	endopeptidase activator activity
W	0071300	biological_process	cellular response to retinoic acid
W	0098803	cellular_component	respiratory chain complex
W	1900119	biological_process	positive regulation of execution phase of apoptosis
x	0004129	molecular_function	cytochrome-c oxidase activity
x	0005743	cellular_component	mitochondrial inner membrane
x	0006119	biological_process	oxidative phosphorylation
x	0009060	biological_process	aerobic respiration
x	0016020	cellular_component	membrane
x	0020037	molecular_function	heme binding
x	0022904	biological_process	respiratory electron transport chain
x	0045277	cellular_component	respiratory chain complex IV
x	0046872	molecular_function	metal ion binding
x	1902600	biological_process	proton transmembrane transport
X	0006633	biological_process	fatty acid biosynthetic process
y	0004129	molecular_function	cytochrome-c oxidase activity
y	0005507	molecular_function	copper ion binding
y	0005739	cellular_component	mitochondrion
y	0005743	cellular_component	mitochondrial inner membrane
y	0016020	cellular_component	membrane
y	0016491	molecular_function	oxidoreductase activity
y	0017004	biological_process	cytochrome complex assembly
y	0022900	biological_process	electron transport chain
y	0022904	biological_process	respiratory electron transport chain
y	0031966	cellular_component	mitochondrial membrane
y	0042773	biological_process	ATP synthesis coupled electron transport
y	0045277	cellular_component	respiratory chain complex IV
y	0046872	molecular_function	metal ion binding
y	1902600	biological_process	proton transmembrane transport
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0045271	cellular_component	respiratory chain complex I
z	0004129	molecular_function	cytochrome-c oxidase activity
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
z	0008535	biological_process	respiratory chain complex IV assembly
z	0009055	molecular_function	electron transfer activity
z	0016020	cellular_component	membrane
z	0019646	biological_process	aerobic electron transport chain
z	0022904	biological_process	respiratory electron transport chain
z	0045277	cellular_component	respiratory chain complex IV
z	1902600	biological_process	proton transmembrane transport
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SF4 A 501

Chain	Residue
A	ILE205
A	CYS425
A	PRO223
A	SER378
A	CYS379
A	GLN381
A	CYS382
A	CYS385
A	THR423
A	ILE424

site_id	AC2
Number of Residues	11
Details	binding site for residue FMN A 502

Chain	Residue
A	GLY87
A	ARG88
A	GLY89
A	ASN116
A	GLU119
A	GLY207
A	GLU208
A	GLU209
A	ALA243
A	ASN244
A	ALA426

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 B 301

Chain	Residue
B	CYS111
B	ALA113
B	CYS114
B	LYS115
B	CYS117
B	CYS160
B	ALA164
B	ILE165

site_id	AC4
Number of Residues	11
Details	binding site for residue SF4 B 302

Chain	Residue
B	HIS99
B	CYS121
B	PRO122
B	CYS150
B	ILE151
B	TYR152
B	CYS153
B	GLY154
B	PHE155
B	CYS156
B	GLU167

site_id	AC5
Number of Residues	11
Details	binding site for residue PLX B 303

Chain	Residue
B	THR58
B	TRP61
Q	ARG266
Q	ASN270
s	MET183
s	MET184
s	ILE273
s	TYR277
s	PHE280
s	LEU288
s	ASN292

site_id	AC6
Number of Residues	9
Details	binding site for residue SF4 C 301

Chain	Residue
C	ALA87
C	CYS88
C	CYS89
C	GLY151
C	SER152
C	CYS153
C	CYS183
C	PRO184
Q	HIS223

site_id	AC7
Number of Residues	9
Details	binding site for residue 8Q1 E 201

Chain	Residue
E	MET25
E	TRP39
E	MET66
E	PHE67
E	ASN70
E	VAL79
E	LEU82
E	VAL83
G	SER112

site_id	AC8
Number of Residues	18
Details	binding site for residue NDP J 401

Chain	Residue
J	GLY60
J	THR62
J	GLY63
J	PHE64
J	LEU65
J	ALA110
J	LEU129
J	ILE130
J	GLY131
J	ARG132
J	PHE145
J	SER168
J	HIS169
J	TYR180
J	LYS184
J	PRO203
J	ILE206
J	ARG212

site_id	AC9
Number of Residues	9
Details	binding site for residue SF4 M 801

Chain	Residue
M	HIS124
M	ASP127
M	CYS128
M	CYS131
M	GLY134
M	CYS137
M	GLN140
M	VAL228
M	GLY229

site_id	AD1
Number of Residues	9
Details	binding site for residue SF4 M 802

Chain	Residue
M	CYS182
M	CYS226
M	PRO227
M	VAL228
M	ALA230
M	LEU231
M	CYS176
M	ILE177
M	CYS179

site_id	AD2
Number of Residues	9
Details	binding site for residue FES M 803

Chain	Residue
M	ARG62
M	CYS64
M	TYR65
M	ALA72
M	ASN74
M	CYS75
M	MET77
M	CYS78
M	CYS92

site_id	AD3
Number of Residues	9
Details	binding site for residue FES O 301

Chain	Residue
O	CYS135
O	THR137
O	PRO139
O	CYS140
O	CYS176
O	LEU177
O	GLY178
O	ALA179
O	CYS180

site_id	AD4
Number of Residues	8
Details	binding site for residue PLX U 101

Chain	Residue
U	ALA12
U	GLU16
U	PHE23
U	GLY26
j	TRP106
j	LEU107
j	ASP112
s	PRO295

site_id	AD5
Number of Residues	11
Details	binding site for residue CDL V 201

Chain	Residue
V	THR35
V	TYR39
V	ARG40
V	ASN44
V	TYR59
V	THR62
i	PRO110
i	HIS112
i	LEU160
l	ILE576
l	THR577

site_id	AD6
Number of Residues	5
Details	binding site for residue PEE V 202

Chain	Residue
V	TRP133
i	LEU276
i	ILE277
i	THR284
l	PEE701

site_id	AD7
Number of Residues	8
Details	binding site for residue PLX V 203

Chain	Residue
AA	ARG43
V	TYR108
V	GLY109
V	ALA112
l	LEU553
o	PRO82
o	ALA91
o	PHE95

site_id	AD8
Number of Residues	12
Details	binding site for residue PEE W 201

Chain	Residue
S	HIS40
W	PHE140
W	MET141
W	TYR143
W	THR144
j	LEU7
m	VAL37
m	LEU44
m	PHE56
s	LEU77
s	LEU98
s	PHE104

site_id	AD9
Number of Residues	9
Details	binding site for residue PLX b 201

Chain	Residue
a	THR87
a	ASN90
a	GLN95
b	TYR84
b	TYR88
b	GLU92
d	ARG43
e	TYR108
r	PLX502

site_id	AE1
Number of Residues	10
Details	binding site for residue PLX g 201

Chain	Residue
g	PRO9
g	LEU10
g	PHE12
g	ARG77
h	PRO2
h	PHE3
i	THR132
i	TRP133
i	TYR143
i	ILE346

site_id	AE2
Number of Residues	4
Details	binding site for residue PLX g 202

Chain	Residue
f	HIS62
g	LEU25
g	PHE35
g	PHE68

site_id	AE3
Number of Residues	10
Details	binding site for residue PLX g 203

Chain	Residue
f	LYS43
f	THR47
g	ARG48
g	ARG50
g	ARG59
g	LEU62
g	TYR63
g	PHE67
i	PRO324
i	PHE325

site_id	AE4
Number of Residues	9
Details	binding site for residue CDL i 401

Chain	Residue
g	LEU46
i	THR238
i	TRP239
i	THR241
i	PRO242
i	LEU243
r	TRP16
r	SER90
r	LYS93

site_id	AE5
Number of Residues	11
Details	binding site for residue PEE l 701

Chain	Residue
Q	GLN46
Q	TYR53
V	PEE202
i	ILE285
i	LEU288
i	TYR291
i	ARG295
l	SER567
l	GLN570
l	ILE571
r	VAL155

site_id	AE6
Number of Residues	11
Details	binding site for residue PEE l 702

Chain	Residue
c	ARG116
l	THR166
l	GLN170
l	LEU173
l	TYR174
l	MET533
l	HIS534
l	ILE537
l	PRO538
l	GLY541
l	THR544

site_id	AE7
Number of Residues	13
Details	binding site for residue CDL l 703

Chain	Residue
a	LEU68
a	LEU71
a	ARG72
l	THR22
l	LEU23
l	PRO26
l	LYS28
l	GLN116
l	LYS119
l	TYR120
r	LEU354
r	PHE357
r	LEU360

site_id	AE8
Number of Residues	6
Details	binding site for residue CDL l 704

Chain	Residue
c	ASP148
l	SER209
l	THR211
l	LEU214
l	LEU272
r	ASN390

site_id	AE9
Number of Residues	11
Details	binding site for residue CDL n 101

Chain	Residue
g	THR26
g	LEU31
g	TYR32
i	PRO338
n	TYR26
n	LYS30
n	ARG34
r	THR55
r	PHE121
u	PHE169
u	TRP170

site_id	AF1
Number of Residues	15
Details	binding site for residue 8Q1 p 201

Chain	Residue
X	ASP111
X	SER112
X	LEU113
p	GLN13
p	ALA23
p	HIS26
p	LEU27
p	MET44
p	ARG47
p	PHE48
p	HIS51
p	LYS52
p	GLU54
p	ALA60
p	ARG74

site_id	AF2
Number of Residues	7
Details	binding site for residue PLX r 501

Chain	Residue
o	TYR102
r	ASN188
r	TRP190
r	ASN193
r	HIS256
r	MET257
r	PRO260

site_id	AF3
Number of Residues	8
Details	binding site for residue PLX r 502

Chain	Residue
b	PLX201
e	ALA107
e	TYR108
l	ILE16
r	LEU68
r	TRP71
r	LEU447
r	ASN450

site_id	AF4
Number of Residues	3
Details	binding site for residue CU x 601

Chain	Residue
x	HIS240
x	HIS290
x	HIS291

site_id	AF5
Number of Residues	3
Details	binding site for residue MG x 602

Chain	Residue
x	HIS368
x	ASP369
y	GLU198

site_id	AF6
Number of Residues	23
Details	binding site for residue HEA x 603

Chain	Residue
x	GLY27
x	MET28
x	SER34
x	ILE37
x	ARG38
x	TYR54
x	VAL58
x	HIS61
x	ALA62
x	MET65
x	ILE66
x	VAL70
x	GLY125
x	TRP126
x	TYR371
x	PHE377
x	HIS378
x	SER382
x	PHE425
x	GLN428
x	ARG438
x	ARG439
x	MET468

site_id	AF7
Number of Residues	22
Details	binding site for residue HEA x 604

Chain	Residue
x	TRP126
x	TRP236
x	VAL243
x	TYR244
x	HIS290
x	HIS291
x	THR309
x	ALA313
x	THR316
x	GLY317
x	GLY352
x	LEU353
x	GLY355
x	ILE356
x	LEU358
x	ALA359
x	ASP364
x	HIS368
x	HIS376
x	PHE377
x	VAL380
x	ARG438

site_id	AF8
Number of Residues	5
Details	binding site for residue CU y 301

Chain	Residue
y	HIS161
y	CYS196
y	CYS200
y	MET207
y	CU302

site_id	AF9
Number of Residues	5
Details	binding site for residue CU y 302

Chain	Residue
y	CYS196
y	GLU198
y	CYS200
y	HIS204
y	CU301

site_id	AG1
Number of Residues	4
Details	binding site for residue ZN 2 101

Chain	Residue
2	CYS60
2	CYS62
2	CYS82
2	CYS85

site_id	AG2
Number of Residues	8
Details	binding site for residue CDL AA 101

Chain	Residue
AA	ARG41
AA	ILE42
AA	SER45
AF	HIS73
AH	CDL403
AJ	ALA29
AJ	PHE33
AJ	PEE403

site_id	AG3
Number of Residues	6
Details	binding site for residue FES AC 301

Chain	Residue
AC	CYS217
AC	HIS219
AC	LEU220
AC	CYS236
AC	HIS239
AC	SER241

site_id	AG4
Number of Residues	8
Details	binding site for residue CDL AG 101

Chain	Residue
AC	VAL137
AC	SER141
AG	ASP37
AG	TRP38
AG	ARG39
AV	TYR155
AV	ILE156
AV	TRP163

site_id	AG5
Number of Residues	10
Details	binding site for residue PEE AH 401

Chain	Residue
AC	ASN131
AC	ALA132
AC	PHE136
AD	ASP37
AH	HIS284
AH	MET288
AH	LYS291
AJ	LEU236
AJ	MET240
AL	PLX501

site_id	AG6
Number of Residues	17
Details	binding site for residue HEC AH 402

Chain	Residue
AH	VAL120
AH	CYS121
AH	CYS124
AH	HIS125
AH	ASN189
AH	LEU197
AH	ILE200
AH	ARG204
AH	TYR210
AH	LEU214
AH	PHE237
AH	ILE242
AH	ALA243
AH	MET244
AH	PRO247
AH	VAL270
AP	HIS239

site_id	AG7
Number of Residues	14
Details	binding site for residue CDL AH 403

Chain	Residue
AA	ASN37
AA	ARG41
AA	CDL101
AF	LYS72
AF	HIS73
AH	TYR304
AH	LYS307
AH	ARG308
AH	LYS315
AJ	ASN32
AJ	LYS227
AJ	LEU230
AJ	LEU234
AJ	SER238

site_id	AG8
Number of Residues	15
Details	binding site for residue HEM AJ 401

Chain	Residue
AJ	LEU41
AJ	GLN44
AJ	ILE45
AJ	GLY48
AJ	LEU51
AJ	ALA52
AJ	ARG80
AJ	HIS83
AJ	GLY130
AJ	LEU133
AJ	PRO134
AJ	HIS182
AJ	PHE183
AJ	PRO186
AJ	TYR273

site_id	AG9
Number of Residues	16
Details	binding site for residue HEM AJ 402

Chain	Residue
AJ	TRP31
AJ	GLY34
AJ	SER35
AJ	LEU37
AJ	HIS97
AJ	ILE98
AJ	ARG100
AJ	SER106
AJ	TYR109
AJ	TRP113
AJ	GLY116
AJ	LEU119
AJ	HIS196
AJ	LEU200
AJ	SER205
AJ	ASN206

site_id	AH1
Number of Residues	15
Details	binding site for residue PEE AJ 403

Chain	Residue
AA	GLU44
AA	VAL49
AA	CDL101
AJ	TRP30
AJ	ILE92
AJ	PHE95
AJ	LEU96
AJ	GLY99
AJ	ARG100
AJ	TYR103
AJ	TYR104
AJ	MET316
AJ	TYR325
AJ	TRP326
AJ	LEU332

site_id	AH2
Number of Residues	10
Details	binding site for residue CDL AJ 404

Chain	Residue
AJ	THR194
AJ	LEU195
AJ	LEU197
AJ	LEU198
AJ	HIS201
AV	LEU13
AV	SER17
AV	THR194
AV	LEU198
AV	HIS201

site_id	AH3
Number of Residues	8
Details	binding site for residue CDL AJ 405

Chain	Residue
AJ	ASP159
AJ	LEU160
AJ	TRP163
AP	THR134
AP	VAL137
AP	SER138
AT	THR36
AY	PEE502

site_id	AH4
Number of Residues	10
Details	binding site for residue PLX AL 501

Chain	Residue
AC	TYR115
AC	THR118
AD	PHE15
AD	THR18
AD	PHE21
AD	ALA22
AH	PEE401
AJ	ALA229
AL	PHE476
AL	PEE503

site_id	AH5
Number of Residues	10
Details	binding site for residue CDL AL 502

Chain	Residue
AJ	ARG5
AJ	PHE18
AJ	ILE19
AJ	HIS221
AL	PHE370
AL	ARG470
AL	TRP477
AL	LEU478
AL	ARG479
AL	PEE503

site_id	AH6
Number of Residues	5
Details	binding site for residue PEE AL 503

Chain	Residue
AJ	HIS221
AL	SER473
AL	PHE476
AL	PLX501
AL	CDL502

site_id	AH7
Number of Residues	7
Details	binding site for residue CDL AN 101

Chain	Residue
AN	ARG41
AN	SER45
AS	HIS73
AU	CDL403
AV	ALA29
AV	PHE33
AV	PEE403

site_id	AH8
Number of Residues	8
Details	binding site for residue FES AP 301

Chain	Residue
AP	CYS217
AP	HIS219
AP	LEU220
AP	CYS222
AP	CYS236
AP	CYS238
AP	HIS239
AP	SER241

site_id	AH9
Number of Residues	12
Details	binding site for residue PLX AQ 101

Chain	Residue
AP	TYR115
AP	THR118
AP	THR122
AP	VAL125
AQ	PHE15
AQ	ARG16
AQ	THR18
AQ	PHE21
AQ	ALA22
AY	PHE476
AY	CDL501
AY	PEE502

site_id	AI1
Number of Residues	3
Details	binding site for residue PLX AT 101

Chain	Residue
AT	ARG9
AT	LEU13
AY	TRP477

site_id	AI2
Number of Residues	9
Details	binding site for residue PEE AU 401

Chain	Residue
AP	TYR127
AP	ALA128
AP	ASN131
AU	MET288
AU	LYS291
AU	MET295
AU	MET296
AV	LEU236
AV	MET240

site_id	AI3
Number of Residues	15
Details	binding site for residue HEC AU 402

Chain	Residue
AC	HIS239
AU	VAL120
AU	CYS121
AU	CYS124
AU	HIS125
AU	ILE200
AU	ARG204
AU	TYR210
AU	LEU214
AU	LEU215
AU	PHE237
AU	ILE242
AU	MET244
AU	PRO247
AU	VAL270

site_id	AI4
Number of Residues	11
Details	binding site for residue CDL AU 403

Chain	Residue
AN	VAL30
AN	CDL101
AU	PRO301
AU	TYR304
AU	LYS307
AU	ARG308
AU	LYS315
AV	LEU36
AV	LYS227
AV	LEU230
AV	LEU234

site_id	AI5
Number of Residues	14
Details	binding site for residue HEM AV 401

Chain	Residue
AV	LEU41
AV	GLN44
AV	ILE45
AV	GLY48
AV	LEU49
AV	ARG80
AV	HIS83
AV	ALA87
AV	PHE90
AV	GLY130
AV	HIS182
AV	PHE183
AV	PRO186
AV	TYR273

site_id	AI6
Number of Residues	17
Details	binding site for residue HEM AV 402

Chain	Residue
AV	TRP31
AV	GLY34
AV	SER35
AV	LEU37
AV	GLY38
AV	LEU94
AV	HIS97
AV	ILE98
AV	SER106
AV	TYR109
AV	GLY116
AV	LEU119
AV	HIS196
AV	LEU197
AV	LEU200
AV	SER205
AV	ASN206

site_id	AI7
Number of Residues	13
Details	binding site for residue PEE AV 403

Chain	Residue
AN	VAL49
AN	PHE53
AN	CDL101
AV	TRP30
AV	PHE95
AV	LEU96
AV	TYR103
AV	TYR104
AV	MET316
AV	TYR325
AV	TRP326
AV	LEU332
AV	LEU333

site_id	AI8
Number of Residues	9
Details	binding site for residue CDL AY 501

Chain	Residue
AQ	PLX101
AT	TRP24
AV	ARG5
AV	HIS221
AY	PHE370
AY	TRP477
AY	LEU478
AY	ARG479
AY	PEE502

site_id	AI9
Number of Residues	10
Details	binding site for residue PEE AY 502

Chain	Residue
AJ	CDL405
AP	ALA126
AQ	PLX101
AT	ALA35
AV	LEU10
AV	ILE14
AV	HIS221
AY	SER473
AY	PHE476
AY	CDL501

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
G	ASP107-MET122

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
G	ASP132-ILE144

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
x	TRP236-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
y	VAL159-MET207

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedfsnlGtTHLLRLTsSlTT

Chain	Residue	Details
AW	GLY68-THR91

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
B	CYS111-PRO122
B	CYS150-PRO161

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
A	GLY200-SER215

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
A	GLU377-GLY388

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFaDAMKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
2	VAL69-LEU91

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP

Chain	Residue	Details
C	GLY169-PRO185

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
3	ILE55-ASN72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q91YT0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	29
Details	Domain: {"description":"4Fe-4S ferredoxin-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00711","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Hydroxyarginine","evidences":[{"source":"PubMed","id":"27226634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ75","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	150
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CR21","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31664822","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ODD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CPP6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	128
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z1P6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DC69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"20433953","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	78
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	39
Details	Domain: {"description":"4Fe-4S His(Cys)3-ligated-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	56
Details	Domain: {"description":"4Fe-4S Mo/W bis-MGD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01004","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01184","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91VD9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04394","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"5XTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D6J6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"22823520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91WD5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"Symmetric dimethylarginine","evidences":[{"source":"PubMed","id":"24089531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24838397","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	933
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52503","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q02371","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q8HXG6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	42
Details	Region: {"description":"Important for inducing cell death"}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQZ6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3UIU2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	132
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	30
Details	Motif: {"description":"Cx9C motif 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	41
Details	Domain: {"description":"CHCH 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	43
Details	Domain: {"description":"CHCH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	10
Details	Motif: {"description":"Cx9C motif 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9CR61","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI68
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99LC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI69
Number of Residues	75
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI70
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI71
Number of Residues	9
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI72
Number of Residues	87
Details	Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI73
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=III","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI74
Number of Residues	47
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI75
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI76
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=V","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI77
Number of Residues	65
Details	Transmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI78
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI79
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=VIII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI80
Number of Residues	120
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI81
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=IX","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI82
Number of Residues	279
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI83
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=X","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI84
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=XI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI85
Number of Residues	31
Details	Transmembrane: {"description":"Helical; Name=XII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI86
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23537388","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI87
Number of Residues	3
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI88
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI89
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI90
Number of Residues	1
Details	Modified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI91
Number of Residues	2
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"PubMed","id":"10338009","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI92
Number of Residues	1
Details	Modified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"220175","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI93
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P00406","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI94
Number of Residues	192
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI95
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI96
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P13073","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI97
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P10888","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI98
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI99
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P12787","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI100
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P20674","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI101
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI102
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19536","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI103
Number of Residues	10
Details	Motif: {"description":"Cx9C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI104
Number of Residues	11
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI105
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P56391","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI106
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17665","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI107
Number of Residues	178
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI108
Number of Residues	288
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI109
Number of Residues	714
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI110
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CQ69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI111
Number of Residues	170
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI112
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13272","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI113
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P99028","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI114
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI115
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D855","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI116
Number of Residues	202
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI117
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"UniProtKB","id":"P00125","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI118
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI119
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"28844695","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XTH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI120
Number of Residues	322
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI121
Number of Residues	8
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI122
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI123
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DB77","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI124
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI125
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9CZ13","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI126
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68FY0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)