5XTH

Cryo-EM structure of human respiratory supercomplex I1III2IV1

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0005751	cellular_component	mitochondrial respiratory chain complex IV
0	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
1	0005743	cellular_component	mitochondrial inner membrane
1	0005751	cellular_component	mitochondrial respiratory chain complex IV
1	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
2	0005740	cellular_component	mitochondrial envelope
2	0005751	cellular_component	mitochondrial respiratory chain complex IV
2	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
3	0005743	cellular_component	mitochondrial inner membrane
3	0005751	cellular_component	mitochondrial respiratory chain complex IV
4	0005739	cellular_component	mitochondrion
4	0045277	cellular_component	respiratory chain complex IV
5	0005739	cellular_component	mitochondrion
5	0005743	cellular_component	mitochondrial inner membrane
5	0006119	biological_process	oxidative phosphorylation
5	0016020	cellular_component	membrane
5	0045277	cellular_component	respiratory chain complex IV
6	0005746	cellular_component	mitochondrial respirasome
6	0005751	cellular_component	mitochondrial respiratory chain complex IV
6	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
7	0005746	cellular_component	mitochondrial respirasome
7	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
8	0005751	cellular_component	mitochondrial respiratory chain complex IV
8	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
9	0005751	cellular_component	mitochondrial respiratory chain complex IV
9	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0003954	molecular_function	NADH dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005747	cellular_component	mitochondrial respiratory chain complex I
A	0005829	cellular_component	cytosol
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0009060	biological_process	aerobic respiration
A	0010181	molecular_function	FMN binding
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
A	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
A	0045271	cellular_component	respiratory chain complex I
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0055085	biological_process	transmembrane transport
A	0070469	cellular_component	respirasome
AA	0005739	cellular_component	mitochondrion
AA	0005743	cellular_component	mitochondrial inner membrane
AA	0005750	cellular_component	mitochondrial respiratory chain complex III
AA	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AA	0016020	cellular_component	membrane
AA	0021539	biological_process	subthalamus development
AA	0021548	biological_process	pons development
AA	0021680	biological_process	cerebellar Purkinje cell layer development
AA	0021766	biological_process	hippocampus development
AA	0021794	biological_process	thalamus development
AA	0021854	biological_process	hypothalamus development
AA	0021860	biological_process	pyramidal neuron development
AA	0030901	biological_process	midbrain development
AA	0045333	biological_process	cellular respiration
AA	0070469	cellular_component	respirasome
AB	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AC	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AC	0016020	cellular_component	membrane
AC	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AD	0005515	molecular_function	protein binding
AD	0005739	cellular_component	mitochondrion
AD	0005743	cellular_component	mitochondrial inner membrane
AD	0005750	cellular_component	mitochondrial respiratory chain complex III
AD	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AD	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AD	0016020	cellular_component	membrane
AD	0045333	biological_process	cellular respiration
AD	0070469	cellular_component	respirasome
AD	1902600	biological_process	proton transmembrane transport
AE	0005750	cellular_component	mitochondrial respiratory chain complex III
AE	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0005515	molecular_function	protein binding
AF	0005739	cellular_component	mitochondrion
AF	0005743	cellular_component	mitochondrial inner membrane
AF	0005746	cellular_component	mitochondrial respirasome
AF	0005750	cellular_component	mitochondrial respiratory chain complex III
AF	0006119	biological_process	oxidative phosphorylation
AF	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AF	0009060	biological_process	aerobic respiration
AF	0016020	cellular_component	membrane
AF	0045333	biological_process	cellular respiration
AF	0070469	cellular_component	respirasome
AG	0005739	cellular_component	mitochondrion
AG	0005743	cellular_component	mitochondrial inner membrane
AG	0005750	cellular_component	mitochondrial respiratory chain complex III
AG	0006091	biological_process	generation of precursor metabolites and energy
AG	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AG	0009055	molecular_function	electron transfer activity
AG	0016020	cellular_component	membrane
AG	0045333	biological_process	cellular respiration
AG	0070469	cellular_component	respirasome
AH	0009055	molecular_function	electron transfer activity
AH	0020037	molecular_function	heme binding
AJ	0001666	biological_process	response to hypoxia
AJ	0005739	cellular_component	mitochondrion
AJ	0005743	cellular_component	mitochondrial inner membrane
AJ	0005750	cellular_component	mitochondrial respiratory chain complex III
AJ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AJ	0007584	biological_process	response to nutrient
AJ	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AJ	0009055	molecular_function	electron transfer activity
AJ	0009410	biological_process	response to xenobiotic stimulus
AJ	0009636	biological_process	response to toxic substance
AJ	0009725	biological_process	response to hormone
AJ	0010243	biological_process	response to organonitrogen compound
AJ	0014070	biological_process	response to organic cyclic compound
AJ	0015990	biological_process	electron transport coupled proton transport
AJ	0016020	cellular_component	membrane
AJ	0016491	molecular_function	oxidoreductase activity
AJ	0022904	biological_process	respiratory electron transport chain
AJ	0031100	biological_process	animal organ regeneration
AJ	0032991	cellular_component	protein-containing complex
AJ	0033590	biological_process	response to cobalamin
AJ	0033762	biological_process	response to glucagon
AJ	0044877	molecular_function	protein-containing complex binding
AJ	0045275	cellular_component	respiratory chain complex III
AJ	0045333	biological_process	cellular respiration
AJ	0045471	biological_process	response to ethanol
AJ	0046686	biological_process	response to cadmium ion
AJ	0046688	biological_process	response to copper ion
AJ	0046689	biological_process	response to mercury ion
AJ	0046872	molecular_function	metal ion binding
AJ	0051592	biological_process	response to calcium ion
AJ	0055093	biological_process	response to hyperoxia
AJ	0070469	cellular_component	respirasome
AK	0004222	molecular_function	metalloendopeptidase activity
AK	0005515	molecular_function	protein binding
AK	0005654	cellular_component	nucleoplasm
AK	0005739	cellular_component	mitochondrion
AK	0005743	cellular_component	mitochondrial inner membrane
AK	0005750	cellular_component	mitochondrial respiratory chain complex III
AK	0005751	cellular_component	mitochondrial respiratory chain complex IV
AK	0006119	biological_process	oxidative phosphorylation
AK	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AK	0006508	biological_process	proteolysis
AK	0009060	biological_process	aerobic respiration
AK	0016020	cellular_component	membrane
AK	0045333	biological_process	cellular respiration
AK	0046872	molecular_function	metal ion binding
AK	0070469	cellular_component	respirasome
AL	0005515	molecular_function	protein binding
AL	0005739	cellular_component	mitochondrion
AL	0005743	cellular_component	mitochondrial inner membrane
AL	0005746	cellular_component	mitochondrial respirasome
AL	0005750	cellular_component	mitochondrial respiratory chain complex III
AL	0006119	biological_process	oxidative phosphorylation
AL	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AL	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AL	0009060	biological_process	aerobic respiration
AL	0014823	biological_process	response to activity
AL	0016020	cellular_component	membrane
AL	0031625	molecular_function	ubiquitin protein ligase binding
AL	0043279	biological_process	response to alkaloid
AL	0044877	molecular_function	protein-containing complex binding
AL	0045333	biological_process	cellular respiration
AL	0046872	molecular_function	metal ion binding
AL	0070469	cellular_component	respirasome
AL	1902600	biological_process	proton transmembrane transport
AN	0005739	cellular_component	mitochondrion
AN	0005743	cellular_component	mitochondrial inner membrane
AN	0005750	cellular_component	mitochondrial respiratory chain complex III
AN	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AN	0016020	cellular_component	membrane
AN	0021539	biological_process	subthalamus development
AN	0021548	biological_process	pons development
AN	0021680	biological_process	cerebellar Purkinje cell layer development
AN	0021766	biological_process	hippocampus development
AN	0021794	biological_process	thalamus development
AN	0021854	biological_process	hypothalamus development
AN	0021860	biological_process	pyramidal neuron development
AN	0030901	biological_process	midbrain development
AN	0045333	biological_process	cellular respiration
AN	0070469	cellular_component	respirasome
AO	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AP	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AP	0016020	cellular_component	membrane
AP	0051537	molecular_function	2 iron, 2 sulfur cluster binding
AQ	0005515	molecular_function	protein binding
AQ	0005739	cellular_component	mitochondrion
AQ	0005743	cellular_component	mitochondrial inner membrane
AQ	0005750	cellular_component	mitochondrial respiratory chain complex III
AQ	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AQ	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AQ	0016020	cellular_component	membrane
AQ	0045333	biological_process	cellular respiration
AQ	0070469	cellular_component	respirasome
AQ	1902600	biological_process	proton transmembrane transport
AR	0005750	cellular_component	mitochondrial respiratory chain complex III
AR	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0005515	molecular_function	protein binding
AS	0005739	cellular_component	mitochondrion
AS	0005743	cellular_component	mitochondrial inner membrane
AS	0005746	cellular_component	mitochondrial respirasome
AS	0005750	cellular_component	mitochondrial respiratory chain complex III
AS	0006119	biological_process	oxidative phosphorylation
AS	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AS	0009060	biological_process	aerobic respiration
AS	0016020	cellular_component	membrane
AS	0045333	biological_process	cellular respiration
AS	0070469	cellular_component	respirasome
AT	0005739	cellular_component	mitochondrion
AT	0005743	cellular_component	mitochondrial inner membrane
AT	0005750	cellular_component	mitochondrial respiratory chain complex III
AT	0006091	biological_process	generation of precursor metabolites and energy
AT	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AT	0009055	molecular_function	electron transfer activity
AT	0016020	cellular_component	membrane
AT	0045333	biological_process	cellular respiration
AT	0070469	cellular_component	respirasome
AU	0009055	molecular_function	electron transfer activity
AU	0020037	molecular_function	heme binding
AV	0001666	biological_process	response to hypoxia
AV	0005739	cellular_component	mitochondrion
AV	0005743	cellular_component	mitochondrial inner membrane
AV	0005750	cellular_component	mitochondrial respiratory chain complex III
AV	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AV	0007584	biological_process	response to nutrient
AV	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AV	0009055	molecular_function	electron transfer activity
AV	0009410	biological_process	response to xenobiotic stimulus
AV	0009636	biological_process	response to toxic substance
AV	0009725	biological_process	response to hormone
AV	0010243	biological_process	response to organonitrogen compound
AV	0014070	biological_process	response to organic cyclic compound
AV	0015990	biological_process	electron transport coupled proton transport
AV	0016020	cellular_component	membrane
AV	0016491	molecular_function	oxidoreductase activity
AV	0022904	biological_process	respiratory electron transport chain
AV	0031100	biological_process	animal organ regeneration
AV	0032991	cellular_component	protein-containing complex
AV	0033590	biological_process	response to cobalamin
AV	0033762	biological_process	response to glucagon
AV	0044877	molecular_function	protein-containing complex binding
AV	0045275	cellular_component	respiratory chain complex III
AV	0045333	biological_process	cellular respiration
AV	0045471	biological_process	response to ethanol
AV	0046686	biological_process	response to cadmium ion
AV	0046688	biological_process	response to copper ion
AV	0046689	biological_process	response to mercury ion
AV	0046872	molecular_function	metal ion binding
AV	0051592	biological_process	response to calcium ion
AV	0055093	biological_process	response to hyperoxia
AV	0070469	cellular_component	respirasome
AW	0004222	molecular_function	metalloendopeptidase activity
AW	0005515	molecular_function	protein binding
AW	0005654	cellular_component	nucleoplasm
AW	0005739	cellular_component	mitochondrion
AW	0005743	cellular_component	mitochondrial inner membrane
AW	0005750	cellular_component	mitochondrial respiratory chain complex III
AW	0005751	cellular_component	mitochondrial respiratory chain complex IV
AW	0006119	biological_process	oxidative phosphorylation
AW	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AW	0006508	biological_process	proteolysis
AW	0009060	biological_process	aerobic respiration
AW	0016020	cellular_component	membrane
AW	0045333	biological_process	cellular respiration
AW	0046872	molecular_function	metal ion binding
AW	0070469	cellular_component	respirasome
AY	0005515	molecular_function	protein binding
AY	0005739	cellular_component	mitochondrion
AY	0005743	cellular_component	mitochondrial inner membrane
AY	0005746	cellular_component	mitochondrial respirasome
AY	0005750	cellular_component	mitochondrial respiratory chain complex III
AY	0006119	biological_process	oxidative phosphorylation
AY	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
AY	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
AY	0009060	biological_process	aerobic respiration
AY	0014823	biological_process	response to activity
AY	0016020	cellular_component	membrane
AY	0031625	molecular_function	ubiquitin protein ligase binding
AY	0043279	biological_process	response to alkaloid
AY	0044877	molecular_function	protein-containing complex binding
AY	0045333	biological_process	cellular respiration
AY	0046872	molecular_function	metal ion binding
AY	0070469	cellular_component	respirasome
AY	1902600	biological_process	proton transmembrane transport
B	0016020	cellular_component	membrane
B	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0048038	molecular_function	quinone binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
E	0005747	cellular_component	mitochondrial respiratory chain complex I
G	0006633	biological_process	fatty acid biosynthetic process
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005747	cellular_component	mitochondrial respiratory chain complex I
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0022904	biological_process	respiratory electron transport chain
H	0032981	biological_process	mitochondrial respiratory chain complex I assembly
H	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
H	0045271	cellular_component	respiratory chain complex I
H	0055085	biological_process	transmembrane transport
H	0070469	cellular_component	respirasome
I	0003735	molecular_function	structural constituent of ribosome
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005747	cellular_component	mitochondrial respiratory chain complex I
I	0005761	cellular_component	mitochondrial ribosome
I	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
I	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0032543	biological_process	mitochondrial translation
I	0042773	biological_process	ATP synthesis coupled electron transport
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0055085	biological_process	transmembrane transport
I	0070469	cellular_component	respirasome
K	0005739	cellular_component	mitochondrion
K	0005747	cellular_component	mitochondrial respiratory chain complex I
L	0022900	biological_process	electron transport chain
M	0003954	molecular_function	NADH dehydrogenase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005747	cellular_component	mitochondrial respiratory chain complex I
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0008637	biological_process	apoptotic mitochondrial changes
M	0009055	molecular_function	electron transfer activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
M	0032981	biological_process	mitochondrial respiratory chain complex I assembly
M	0042773	biological_process	ATP synthesis coupled electron transport
M	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
M	0045333	biological_process	cellular respiration
M	0046034	biological_process	ATP metabolic process
M	0046872	molecular_function	metal ion binding
M	0051536	molecular_function	iron-sulfur cluster binding
M	0051537	molecular_function	2 iron, 2 sulfur cluster binding
M	0051539	molecular_function	4 iron, 4 sulfur cluster binding
M	0051881	biological_process	regulation of mitochondrial membrane potential
M	0055085	biological_process	transmembrane transport
M	0070469	cellular_component	respirasome
M	0072593	biological_process	reactive oxygen species metabolic process
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005747	cellular_component	mitochondrial respiratory chain complex I
N	0005829	cellular_component	cytosol
N	0006979	biological_process	response to oxidative stress
N	0007585	biological_process	respiratory gaseous exchange by respiratory system
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0032981	biological_process	mitochondrial respiratory chain complex I assembly
N	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
N	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
N	0055085	biological_process	transmembrane transport
N	0070469	cellular_component	respirasome
O	0016491	molecular_function	oxidoreductase activity
P	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
P	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0003954	molecular_function	NADH dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005654	cellular_component	nucleoplasm
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005747	cellular_component	mitochondrial respiratory chain complex I
Q	0005759	cellular_component	mitochondrial matrix
Q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
Q	0006979	biological_process	response to oxidative stress
Q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
Q	0009055	molecular_function	electron transfer activity
Q	0009060	biological_process	aerobic respiration
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
Q	0019826	molecular_function	oxygen sensor activity
Q	0022008	biological_process	neurogenesis
Q	0031625	molecular_function	ubiquitin protein ligase binding
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0042063	biological_process	gliogenesis
Q	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
Q	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
Q	0046872	molecular_function	metal ion binding
Q	0048038	molecular_function	quinone binding
Q	0051287	molecular_function	NAD binding
Q	0051536	molecular_function	iron-sulfur cluster binding
Q	0051539	molecular_function	4 iron, 4 sulfur cluster binding
Q	0055085	biological_process	transmembrane transport
Q	0061351	biological_process	neural precursor cell proliferation
Q	0070469	cellular_component	respirasome
Q	0071453	biological_process	cellular response to oxygen levels
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005747	cellular_component	mitochondrial respiratory chain complex I
S	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
S	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
S	0009060	biological_process	aerobic respiration
S	0016020	cellular_component	membrane
S	0031966	cellular_component	mitochondrial membrane
S	0032981	biological_process	mitochondrial respiratory chain complex I assembly
S	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
S	0055085	biological_process	transmembrane transport
S	0070469	cellular_component	respirasome
T	0005747	cellular_component	mitochondrial respiratory chain complex I
T	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0005515	molecular_function	protein binding
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005747	cellular_component	mitochondrial respiratory chain complex I
U	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
U	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
U	0009060	biological_process	aerobic respiration
U	0016020	cellular_component	membrane
U	0032981	biological_process	mitochondrial respiratory chain complex I assembly
U	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
U	0055085	biological_process	transmembrane transport
U	0070469	cellular_component	respirasome
V	0005515	molecular_function	protein binding
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005747	cellular_component	mitochondrial respiratory chain complex I
V	0009060	biological_process	aerobic respiration
V	0016020	cellular_component	membrane
V	0032981	biological_process	mitochondrial respiratory chain complex I assembly
V	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
V	0070469	cellular_component	respirasome
W	0005515	molecular_function	protein binding
W	0005524	molecular_function	ATP binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005746	cellular_component	mitochondrial respirasome
W	0005747	cellular_component	mitochondrial respiratory chain complex I
W	0006915	biological_process	apoptotic process
W	0009060	biological_process	aerobic respiration
W	0016020	cellular_component	membrane
W	0030308	biological_process	negative regulation of cell growth
W	0031966	cellular_component	mitochondrial membrane
W	0032981	biological_process	mitochondrial respiratory chain complex I assembly
W	0035458	biological_process	cellular response to interferon-beta
W	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
W	0045039	biological_process	protein insertion into mitochondrial inner membrane
W	0045732	biological_process	positive regulation of protein catabolic process
W	0045892	biological_process	negative regulation of DNA-templated transcription
W	0061133	molecular_function	endopeptidase activator activity
W	0070469	cellular_component	respirasome
W	0071300	biological_process	cellular response to retinoic acid
W	0072593	biological_process	reactive oxygen species metabolic process
W	0097190	biological_process	apoptotic signaling pathway
W	0097191	biological_process	extrinsic apoptotic signaling pathway
W	1900119	biological_process	positive regulation of execution phase of apoptosis
W	2001243	biological_process	negative regulation of intrinsic apoptotic signaling pathway
X	0006633	biological_process	fatty acid biosynthetic process
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0005747	cellular_component	mitochondrial respiratory chain complex I
Z	0005739	cellular_component	mitochondrion
Z	0022900	biological_process	electron transport chain
b	0005515	molecular_function	protein binding
b	0005654	cellular_component	nucleoplasm
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005747	cellular_component	mitochondrial respiratory chain complex I
b	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
b	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0031966	cellular_component	mitochondrial membrane
b	0032981	biological_process	mitochondrial respiratory chain complex I assembly
b	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
b	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
b	0055085	biological_process	transmembrane transport
b	0070469	cellular_component	respirasome
c	0005739	cellular_component	mitochondrion
c	0005747	cellular_component	mitochondrial respiratory chain complex I
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0005515	molecular_function	protein binding
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0005747	cellular_component	mitochondrial respiratory chain complex I
d	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
d	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
d	0009060	biological_process	aerobic respiration
d	0016020	cellular_component	membrane
d	0032981	biological_process	mitochondrial respiratory chain complex I assembly
d	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
d	0055085	biological_process	transmembrane transport
d	0070469	cellular_component	respirasome
f	0005739	cellular_component	mitochondrion
f	0005747	cellular_component	mitochondrial respiratory chain complex I
g	0005515	molecular_function	protein binding
g	0005737	cellular_component	cytoplasm
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005747	cellular_component	mitochondrial respiratory chain complex I
g	0005886	cellular_component	plasma membrane
g	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
g	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
g	0009060	biological_process	aerobic respiration
g	0016020	cellular_component	membrane
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0035577	cellular_component	azurophil granule membrane
g	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
g	0055085	biological_process	transmembrane transport
g	0070469	cellular_component	respirasome
h	0005515	molecular_function	protein binding
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005747	cellular_component	mitochondrial respiratory chain complex I
h	0005758	cellular_component	mitochondrial intermembrane space
h	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
h	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
h	0009060	biological_process	aerobic respiration
h	0016020	cellular_component	membrane
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
h	0055085	biological_process	transmembrane transport
h	0070469	cellular_component	respirasome
i	0001666	biological_process	response to hypoxia
i	0005515	molecular_function	protein binding
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0005747	cellular_component	mitochondrial respiratory chain complex I
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0009060	biological_process	aerobic respiration
i	0016020	cellular_component	membrane
i	0019901	molecular_function	protein kinase binding
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0035255	molecular_function	ionotropic glutamate receptor binding
i	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
i	0055085	biological_process	transmembrane transport
i	0070469	cellular_component	respirasome
i	0072593	biological_process	reactive oxygen species metabolic process
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005747	cellular_component	mitochondrial respiratory chain complex I
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0016020	cellular_component	membrane
j	0031966	cellular_component	mitochondrial membrane
j	0055085	biological_process	transmembrane transport
j	0070469	cellular_component	respirasome
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0005747	cellular_component	mitochondrial respiratory chain complex I
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0016020	cellular_component	membrane
k	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
k	0042773	biological_process	ATP synthesis coupled electron transport
k	0055085	biological_process	transmembrane transport
k	0070469	cellular_component	respirasome
l	0001666	biological_process	response to hypoxia
l	0003954	molecular_function	NADH dehydrogenase activity
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005747	cellular_component	mitochondrial respiratory chain complex I
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0009060	biological_process	aerobic respiration
l	0010243	biological_process	response to organonitrogen compound
l	0015990	biological_process	electron transport coupled proton transport
l	0016020	cellular_component	membrane
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0042542	biological_process	response to hydrogen peroxide
l	0042773	biological_process	ATP synthesis coupled electron transport
l	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
l	0070469	cellular_component	respirasome
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0005747	cellular_component	mitochondrial respiratory chain complex I
n	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
n	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
n	0009060	biological_process	aerobic respiration
n	0016020	cellular_component	membrane
n	0016607	cellular_component	nuclear speck
n	0032981	biological_process	mitochondrial respiratory chain complex I assembly
n	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
n	0055085	biological_process	transmembrane transport
n	0070469	cellular_component	respirasome
o	0005654	cellular_component	nucleoplasm
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0005747	cellular_component	mitochondrial respiratory chain complex I
o	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
o	0006979	biological_process	response to oxidative stress
o	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
o	0009060	biological_process	aerobic respiration
o	0016020	cellular_component	membrane
o	0032981	biological_process	mitochondrial respiratory chain complex I assembly
o	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
o	0055085	biological_process	transmembrane transport
o	0070469	cellular_component	respirasome
p	0005515	molecular_function	protein binding
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0005747	cellular_component	mitochondrial respiratory chain complex I
p	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
p	0007605	biological_process	sensory perception of sound
p	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
p	0009060	biological_process	aerobic respiration
p	0016020	cellular_component	membrane
p	0032981	biological_process	mitochondrial respiratory chain complex I assembly
p	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
p	0055085	biological_process	transmembrane transport
p	0070469	cellular_component	respirasome
r	0001666	biological_process	response to hypoxia
r	0001701	biological_process	in utero embryonic development
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005739	cellular_component	mitochondrion
r	0005743	cellular_component	mitochondrial inner membrane
r	0005747	cellular_component	mitochondrial respiratory chain complex I
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0015990	biological_process	electron transport coupled proton transport
r	0016020	cellular_component	membrane
r	0021549	biological_process	cerebellum development
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0035094	biological_process	response to nicotine
r	0042773	biological_process	ATP synthesis coupled electron transport
r	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
r	0045271	cellular_component	respiratory chain complex I
r	0045471	biological_process	response to ethanol
r	0048039	molecular_function	ubiquinone binding
r	0070469	cellular_component	respirasome
s	0003954	molecular_function	NADH dehydrogenase activity
s	0005739	cellular_component	mitochondrion
s	0005743	cellular_component	mitochondrial inner membrane
s	0005747	cellular_component	mitochondrial respiratory chain complex I
s	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
s	0009060	biological_process	aerobic respiration
s	0016020	cellular_component	membrane
s	0055085	biological_process	transmembrane transport
s	0070469	cellular_component	respirasome
u	0005515	molecular_function	protein binding
u	0005739	cellular_component	mitochondrion
u	0005743	cellular_component	mitochondrial inner membrane
u	0005747	cellular_component	mitochondrial respiratory chain complex I
u	0005758	cellular_component	mitochondrial intermembrane space
u	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
u	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
u	0009060	biological_process	aerobic respiration
u	0016020	cellular_component	membrane
u	0032981	biological_process	mitochondrial respiratory chain complex I assembly
u	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
u	0044877	molecular_function	protein-containing complex binding
u	0055085	biological_process	transmembrane transport
u	0070469	cellular_component	respirasome
v	0005739	cellular_component	mitochondrion
w	0005737	cellular_component	cytoplasm
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005747	cellular_component	mitochondrial respiratory chain complex I
w	0005759	cellular_component	mitochondrial matrix
w	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
w	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
w	0009060	biological_process	aerobic respiration
w	0019136	molecular_function	deoxynucleoside kinase activity
w	0032981	biological_process	mitochondrial respiratory chain complex I assembly
w	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
w	0055085	biological_process	transmembrane transport
w	0070469	cellular_component	respirasome
x	0004129	molecular_function	cytochrome-c oxidase activity
x	0005739	cellular_component	mitochondrion
x	0005743	cellular_component	mitochondrial inner membrane
x	0005751	cellular_component	mitochondrial respiratory chain complex IV
x	0006119	biological_process	oxidative phosphorylation
x	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
x	0009060	biological_process	aerobic respiration
x	0015990	biological_process	electron transport coupled proton transport
x	0016020	cellular_component	membrane
x	0020037	molecular_function	heme binding
x	0045277	cellular_component	respiratory chain complex IV
x	0046872	molecular_function	metal ion binding
x	0070469	cellular_component	respirasome
y	0004129	molecular_function	cytochrome-c oxidase activity
y	0005507	molecular_function	copper ion binding
y	0005739	cellular_component	mitochondrion
y	0005743	cellular_component	mitochondrial inner membrane
y	0016020	cellular_component	membrane
y	0016491	molecular_function	oxidoreductase activity
y	0022900	biological_process	electron transport chain
y	0042773	biological_process	ATP synthesis coupled electron transport
y	0045277	cellular_component	respiratory chain complex IV
y	0046872	molecular_function	metal ion binding
y	0070469	cellular_component	respirasome
y	1902600	biological_process	proton transmembrane transport
z	0004129	molecular_function	cytochrome-c oxidase activity
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
z	0008535	biological_process	respiratory chain complex IV assembly
z	0009055	molecular_function	electron transfer activity
z	0016020	cellular_component	membrane
z	0019646	biological_process	aerobic electron transport chain
z	0022904	biological_process	respiratory electron transport chain
z	0045277	cellular_component	respiratory chain complex IV
z	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SF4 A 501

Chain	Residue
A	ILE205
A	CYS425
A	PRO223
A	SER378
A	CYS379
A	GLN381
A	CYS382
A	CYS385
A	THR423
A	ILE424

---

site_id	AC2
Number of Residues	11
Details	binding site for residue FMN A 502

Chain	Residue
A	GLY87
A	ARG88
A	GLY89
A	ASN116
A	GLU119
A	GLY207
A	GLU208
A	GLU209
A	ALA243
A	ASN244
A	ALA426

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SF4 B 301

Chain	Residue
B	CYS111
B	ALA113
B	CYS114
B	LYS115
B	CYS117
B	CYS160
B	ALA164
B	ILE165

---

site_id	AC4
Number of Residues	11
Details	binding site for residue SF4 B 302

Chain	Residue
B	HIS99
B	CYS121
B	PRO122
B	CYS150
B	ILE151
B	TYR152
B	CYS153
B	GLY154
B	PHE155
B	CYS156
B	GLU167

---

site_id	AC5
Number of Residues	11
Details	binding site for residue PLX B 303

Chain	Residue
B	THR58
B	TRP61
Q	ARG266
Q	ASN270
s	MET183
s	MET184
s	ILE273
s	TYR277
s	PHE280
s	LEU288
s	ASN292

---

site_id	AC6
Number of Residues	9
Details	binding site for residue SF4 C 301

Chain	Residue
C	ALA87
C	CYS88
C	CYS89
C	GLY151
C	SER152
C	CYS153
C	CYS183
C	PRO184
Q	HIS223

---

site_id	AC7
Number of Residues	9
Details	binding site for residue 8Q1 E 201

Chain	Residue
E	MET25
E	TRP39
E	MET66
E	PHE67
E	ASN70
E	VAL79
E	LEU82
E	VAL83
G	SER112

---

site_id	AC8
Number of Residues	18
Details	binding site for residue NDP J 401

Chain	Residue
J	GLY60
J	THR62
J	GLY63
J	PHE64
J	LEU65
J	ALA110
J	LEU129
J	ILE130
J	GLY131
J	ARG132
J	PHE145
J	SER168
J	HIS169
J	TYR180
J	LYS184
J	PRO203
J	ILE206
J	ARG212

---

site_id	AC9
Number of Residues	9
Details	binding site for residue SF4 M 801

Chain	Residue
M	HIS124
M	ASP127
M	CYS128
M	CYS131
M	GLY134
M	CYS137
M	GLN140
M	VAL228
M	GLY229

---

site_id	AD1
Number of Residues	9
Details	binding site for residue SF4 M 802

Chain	Residue
M	CYS182
M	CYS226
M	PRO227
M	VAL228
M	ALA230
M	LEU231
M	CYS176
M	ILE177
M	CYS179

---

site_id	AD2
Number of Residues	9
Details	binding site for residue FES M 803

Chain	Residue
M	ARG62
M	CYS64
M	TYR65
M	ALA72
M	ASN74
M	CYS75
M	MET77
M	CYS78
M	CYS92

---

site_id	AD3
Number of Residues	9
Details	binding site for residue FES O 301

Chain	Residue
O	CYS135
O	THR137
O	PRO139
O	CYS140
O	CYS176
O	LEU177
O	GLY178
O	ALA179
O	CYS180

---

site_id	AD4
Number of Residues	8
Details	binding site for residue PLX U 101

Chain	Residue
U	ALA12
U	GLU16
U	PHE23
U	GLY26
j	TRP106
j	LEU107
j	ASP112
s	PRO295

---

site_id	AD5
Number of Residues	11
Details	binding site for residue CDL V 201

Chain	Residue
V	THR35
V	TYR39
V	ARG40
V	ASN44
V	TYR59
V	THR62
i	PRO110
i	HIS112
i	LEU160
l	ILE576
l	THR577

---

site_id	AD6
Number of Residues	5
Details	binding site for residue PEE V 202

Chain	Residue
V	TRP133
i	LEU276
i	ILE277
i	THR284
l	PEE701

---

site_id	AD7
Number of Residues	8
Details	binding site for residue PLX V 203

Chain	Residue
AA	ARG43
V	TYR108
V	GLY109
V	ALA112
l	LEU553
o	PRO82
o	ALA91
o	PHE95

---

site_id	AD8
Number of Residues	12
Details	binding site for residue PEE W 201

Chain	Residue
S	HIS40
W	PHE140
W	MET141
W	TYR143
W	THR144
j	LEU7
m	VAL37
m	LEU44
m	PHE56
s	LEU77
s	LEU98
s	PHE104

---

site_id	AD9
Number of Residues	9
Details	binding site for residue PLX b 201

Chain	Residue
a	THR87
a	ASN90
a	GLN95
b	TYR84
b	TYR88
b	GLU92
d	ARG43
e	TYR108
r	PLX502

---

site_id	AE1
Number of Residues	10
Details	binding site for residue PLX g 201

Chain	Residue
g	PRO9
g	LEU10
g	PHE12
g	ARG77
h	PRO2
h	PHE3
i	THR132
i	TRP133
i	TYR143
i	ILE346

---

site_id	AE2
Number of Residues	4
Details	binding site for residue PLX g 202

Chain	Residue
f	HIS62
g	LEU25
g	PHE35
g	PHE68

---

site_id	AE3
Number of Residues	10
Details	binding site for residue PLX g 203

Chain	Residue
f	LYS43
f	THR47
g	ARG48
g	ARG50
g	ARG59
g	LEU62
g	TYR63
g	PHE67
i	PRO324
i	PHE325

---

site_id	AE4
Number of Residues	9
Details	binding site for residue CDL i 401

Chain	Residue
g	LEU46
i	THR238
i	TRP239
i	THR241
i	PRO242
i	LEU243
r	TRP16
r	SER90
r	LYS93

---

site_id	AE5
Number of Residues	11
Details	binding site for residue PEE l 701

Chain	Residue
Q	GLN46
Q	TYR53
V	PEE202
i	ILE285
i	LEU288
i	TYR291
i	ARG295
l	SER567
l	GLN570
l	ILE571
r	VAL155

---

site_id	AE6
Number of Residues	11
Details	binding site for residue PEE l 702

Chain	Residue
c	ARG116
l	THR166
l	GLN170
l	LEU173
l	TYR174
l	MET533
l	HIS534
l	ILE537
l	PRO538
l	GLY541
l	THR544

---

site_id	AE7
Number of Residues	13
Details	binding site for residue CDL l 703

Chain	Residue
a	LEU68
a	LEU71
a	ARG72
l	THR22
l	LEU23
l	PRO26
l	LYS28
l	GLN116
l	LYS119
l	TYR120
r	LEU354
r	PHE357
r	LEU360

---

site_id	AE8
Number of Residues	6
Details	binding site for residue CDL l 704

Chain	Residue
c	ASP148
l	SER209
l	THR211
l	LEU214
l	LEU272
r	ASN390

---

site_id	AE9
Number of Residues	11
Details	binding site for residue CDL n 101

Chain	Residue
g	THR26
g	LEU31
g	TYR32
i	PRO338
n	TYR26
n	LYS30
n	ARG34
r	THR55
r	PHE121
u	PHE169
u	TRP170

---

site_id	AF1
Number of Residues	15
Details	binding site for residue 8Q1 p 201

Chain	Residue
X	ASP111
X	SER112
X	LEU113
p	GLN13
p	ALA23
p	HIS26
p	LEU27
p	MET44
p	ARG47
p	PHE48
p	HIS51
p	LYS52
p	GLU54
p	ALA60
p	ARG74

---

site_id	AF2
Number of Residues	7
Details	binding site for residue PLX r 501

Chain	Residue
o	TYR102
r	ASN188
r	TRP190
r	ASN193
r	HIS256
r	MET257
r	PRO260

---

site_id	AF3
Number of Residues	8
Details	binding site for residue PLX r 502

Chain	Residue
b	PLX201
e	ALA107
e	TYR108
l	ILE16
r	LEU68
r	TRP71
r	LEU447
r	ASN450

---

site_id	AF4
Number of Residues	3
Details	binding site for residue CU x 601

Chain	Residue
x	HIS240
x	HIS290
x	HIS291

---

site_id	AF5
Number of Residues	3
Details	binding site for residue MG x 602

Chain	Residue
x	HIS368
x	ASP369
y	GLU198

---

site_id	AF6
Number of Residues	23
Details	binding site for residue HEA x 603

Chain	Residue
x	GLY27
x	MET28
x	SER34
x	ILE37
x	ARG38
x	TYR54
x	VAL58
x	HIS61
x	ALA62
x	MET65
x	ILE66
x	VAL70
x	GLY125
x	TRP126
x	TYR371
x	PHE377
x	HIS378
x	SER382
x	PHE425
x	GLN428
x	ARG438
x	ARG439
x	MET468

---

site_id	AF7
Number of Residues	22
Details	binding site for residue HEA x 604

Chain	Residue
x	TRP126
x	TRP236
x	VAL243
x	TYR244
x	HIS290
x	HIS291
x	THR309
x	ALA313
x	THR316
x	GLY317
x	GLY352
x	LEU353
x	GLY355
x	ILE356
x	LEU358
x	ALA359
x	ASP364
x	HIS368
x	HIS376
x	PHE377
x	VAL380
x	ARG438

---

site_id	AF8
Number of Residues	5
Details	binding site for residue CU y 301

Chain	Residue
y	HIS161
y	CYS196
y	CYS200
y	MET207
y	CU302

---

site_id	AF9
Number of Residues	5
Details	binding site for residue CU y 302

Chain	Residue
y	CYS196
y	GLU198
y	CYS200
y	HIS204
y	CU301

---

site_id	AG1
Number of Residues	4
Details	binding site for residue ZN 2 101

Chain	Residue
2	CYS60
2	CYS62
2	CYS82
2	CYS85

---

site_id	AG2
Number of Residues	8
Details	binding site for residue CDL AA 101

Chain	Residue
AA	ARG41
AA	ILE42
AA	SER45
AF	HIS73
AH	CDL403
AJ	ALA29
AJ	PHE33
AJ	PEE403

---

site_id	AG3
Number of Residues	6
Details	binding site for residue FES AC 301

Chain	Residue
AC	CYS217
AC	HIS219
AC	LEU220
AC	CYS236
AC	HIS239
AC	SER241

---

site_id	AG4
Number of Residues	8
Details	binding site for residue CDL AG 101

Chain	Residue
AC	VAL137
AC	SER141
AG	ASP37
AG	TRP38
AG	ARG39
AV	TYR155
AV	ILE156
AV	TRP163

---

site_id	AG5
Number of Residues	10
Details	binding site for residue PEE AH 401

Chain	Residue
AC	ASN131
AC	ALA132
AC	PHE136
AD	ASP37
AH	HIS284
AH	MET288
AH	LYS291
AJ	LEU236
AJ	MET240
AL	PLX501

---

site_id	AG6
Number of Residues	17
Details	binding site for residue HEC AH 402

Chain	Residue
AH	VAL120
AH	CYS121
AH	CYS124
AH	HIS125
AH	ASN189
AH	LEU197
AH	ILE200
AH	ARG204
AH	TYR210
AH	LEU214
AH	PHE237
AH	ILE242
AH	ALA243
AH	MET244
AH	PRO247
AH	VAL270
AP	HIS239

---

site_id	AG7
Number of Residues	14
Details	binding site for residue CDL AH 403

Chain	Residue
AA	ASN37
AA	ARG41
AA	CDL101
AF	LYS72
AF	HIS73
AH	TYR304
AH	LYS307
AH	ARG308
AH	LYS315
AJ	ASN32
AJ	LYS227
AJ	LEU230
AJ	LEU234
AJ	SER238

---

site_id	AG8
Number of Residues	15
Details	binding site for residue HEM AJ 401

Chain	Residue
AJ	LEU41
AJ	GLN44
AJ	ILE45
AJ	GLY48
AJ	LEU51
AJ	ALA52
AJ	ARG80
AJ	HIS83
AJ	GLY130
AJ	LEU133
AJ	PRO134
AJ	HIS182
AJ	PHE183
AJ	PRO186
AJ	TYR273

---

site_id	AG9
Number of Residues	16
Details	binding site for residue HEM AJ 402

Chain	Residue
AJ	TRP31
AJ	GLY34
AJ	SER35
AJ	LEU37
AJ	HIS97
AJ	ILE98
AJ	ARG100
AJ	SER106
AJ	TYR109
AJ	TRP113
AJ	GLY116
AJ	LEU119
AJ	HIS196
AJ	LEU200
AJ	SER205
AJ	ASN206

---

site_id	AH1
Number of Residues	15
Details	binding site for residue PEE AJ 403

Chain	Residue
AA	GLU44
AA	VAL49
AA	CDL101
AJ	TRP30
AJ	ILE92
AJ	PHE95
AJ	LEU96
AJ	GLY99
AJ	ARG100
AJ	TYR103
AJ	TYR104
AJ	MET316
AJ	TYR325
AJ	TRP326
AJ	LEU332

---

site_id	AH2
Number of Residues	10
Details	binding site for residue CDL AJ 404

Chain	Residue
AJ	THR194
AJ	LEU195
AJ	LEU197
AJ	LEU198
AJ	HIS201
AV	LEU13
AV	SER17
AV	THR194
AV	LEU198
AV	HIS201

---

site_id	AH3
Number of Residues	8
Details	binding site for residue CDL AJ 405

Chain	Residue
AJ	ASP159
AJ	LEU160
AJ	TRP163
AP	THR134
AP	VAL137
AP	SER138
AT	THR36
AY	PEE502

---

site_id	AH4
Number of Residues	10
Details	binding site for residue PLX AL 501

Chain	Residue
AC	TYR115
AC	THR118
AD	PHE15
AD	THR18
AD	PHE21
AD	ALA22
AH	PEE401
AJ	ALA229
AL	PHE476
AL	PEE503

---

site_id	AH5
Number of Residues	10
Details	binding site for residue CDL AL 502

Chain	Residue
AJ	ARG5
AJ	PHE18
AJ	ILE19
AJ	HIS221
AL	PHE370
AL	ARG470
AL	TRP477
AL	LEU478
AL	ARG479
AL	PEE503

---

site_id	AH6
Number of Residues	5
Details	binding site for residue PEE AL 503

Chain	Residue
AJ	HIS221
AL	SER473
AL	PHE476
AL	PLX501
AL	CDL502

---

site_id	AH7
Number of Residues	7
Details	binding site for residue CDL AN 101

Chain	Residue
AN	ARG41
AN	SER45
AS	HIS73
AU	CDL403
AV	ALA29
AV	PHE33
AV	PEE403

---

site_id	AH8
Number of Residues	8
Details	binding site for residue FES AP 301

Chain	Residue
AP	CYS217
AP	HIS219
AP	LEU220
AP	CYS222
AP	CYS236
AP	CYS238
AP	HIS239
AP	SER241

---

site_id	AH9
Number of Residues	12
Details	binding site for residue PLX AQ 101

Chain	Residue
AP	TYR115
AP	THR118
AP	THR122
AP	VAL125
AQ	PHE15
AQ	ARG16
AQ	THR18
AQ	PHE21
AQ	ALA22
AY	PHE476
AY	CDL501
AY	PEE502

---

site_id	AI1
Number of Residues	3
Details	binding site for residue PLX AT 101

Chain	Residue
AT	ARG9
AT	LEU13
AY	TRP477

---

site_id	AI2
Number of Residues	9
Details	binding site for residue PEE AU 401

Chain	Residue
AP	TYR127
AP	ALA128
AP	ASN131
AU	MET288
AU	LYS291
AU	MET295
AU	MET296
AV	LEU236
AV	MET240

---

site_id	AI3
Number of Residues	15
Details	binding site for residue HEC AU 402

Chain	Residue
AC	HIS239
AU	VAL120
AU	CYS121
AU	CYS124
AU	HIS125
AU	ILE200
AU	ARG204
AU	TYR210
AU	LEU214
AU	LEU215
AU	PHE237
AU	ILE242
AU	MET244
AU	PRO247
AU	VAL270

---

site_id	AI4
Number of Residues	11
Details	binding site for residue CDL AU 403

Chain	Residue
AN	VAL30
AN	CDL101
AU	PRO301
AU	TYR304
AU	LYS307
AU	ARG308
AU	LYS315
AV	LEU36
AV	LYS227
AV	LEU230
AV	LEU234

---

site_id	AI5
Number of Residues	14
Details	binding site for residue HEM AV 401

Chain	Residue
AV	LEU41
AV	GLN44
AV	ILE45
AV	GLY48
AV	LEU49
AV	ARG80
AV	HIS83
AV	ALA87
AV	PHE90
AV	GLY130
AV	HIS182
AV	PHE183
AV	PRO186
AV	TYR273

---

site_id	AI6
Number of Residues	17
Details	binding site for residue HEM AV 402

Chain	Residue
AV	TRP31
AV	GLY34
AV	SER35
AV	LEU37
AV	GLY38
AV	LEU94
AV	HIS97
AV	ILE98
AV	SER106
AV	TYR109
AV	GLY116
AV	LEU119
AV	HIS196
AV	LEU197
AV	LEU200
AV	SER205
AV	ASN206

---

site_id	AI7
Number of Residues	13
Details	binding site for residue PEE AV 403

Chain	Residue
AN	VAL49
AN	PHE53
AN	CDL101
AV	TRP30
AV	PHE95
AV	LEU96
AV	TYR103
AV	TYR104
AV	MET316
AV	TYR325
AV	TRP326
AV	LEU332
AV	LEU333

---

site_id	AI8
Number of Residues	9
Details	binding site for residue CDL AY 501

Chain	Residue
AQ	PLX101
AT	TRP24
AV	ARG5
AV	HIS221
AY	PHE370
AY	TRP477
AY	LEU478
AY	ARG479
AY	PEE502

---

site_id	AI9
Number of Residues	10
Details	binding site for residue PEE AY 502

Chain	Residue
AJ	CDL405
AP	ALA126
AQ	PLX101
AT	ALA35
AV	LEU10
AV	ILE14
AV	HIS221
AY	SER473
AY	PHE476
AY	CDL501

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
x	TRP236-HIS291

---

site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
P	GLU167-LEU188

---

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaICP

Chain	Residue	Details
B	CYS111-PRO122
B	CYS150-PRO161

---

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
A	GLY200-SER215

---

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
A	GLU377-GLY388

---

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
Q	LEU116-LYS127

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
2	VAL69-LEU91

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
O	ASP166-PRO184

---

site_id	PS00143
Number of Residues	24
Details	INSULINASE Insulinase family, zinc-binding region signature. GsryedfsnlGtTHLLRLTsSlTT

Chain	Residue	Details
AW	GLY68-THR91

---

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
G	ASP107-MET122

---

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
G	ASP132-ILE144

---

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpFaDAMKLFtKE

Chain	Residue	Details
s	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLAEGEseLVs.G

Chain	Residue	Details
s	PRO197-GLY210

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
3	ILE55-ASN72

---

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
M	PRO61-CYS78

---

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
M	CYS128-GLN140

---

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
M	ARG175-PHE185

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
y	VAL159-MET207

---

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYiPgCPP

Chain	Residue	Details
C	GLY169-PRO185

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	221
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
r	MET22-PHE42
r	LEU351-PRO371
r	ILE391-PHE411
l	TRP407-LEU429
l	ALA458-PHE478
l	ILE482-LEU502
l	GLY582-ILE602
AV	PHE347-PRO367
r	PRO60-SER80
r	LEU102-PHE122
r	ALA145-ILE165
r	TRP196-LEU216
r	PRO224-MET244
r	MET257-LEU277
r	SER284-ILE303
r	SER308-ALA330

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9CZ13

Chain	Residue	Details
AL	LYS138
AL	LYS248
AY	LYS138
AY	LYS248
AV	HIS83
AV	HIS97
AV	HIS182
AV	HIS196

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9CZ13

Chain	Residue	Details
AL	LYS163
AY	LYS163
z	ALA184-ASP190
z	TYR257-SER261

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q68FY0

Chain	Residue	Details
AL	SER212
AP	SER241
AY	SER212
AU	CYS121
AU	CYS124
AC	SER241
AP	CYS217
AP	HIS219
AP	CYS236
AP	HIS239

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:28844695, ECO:0007744|PDB:5XTE, ECO:0007744|PDB:5XTH

Chain	Residue	Details
AH	HIS125
AU	HIS125
y	GLU198
y	CYS200
y	HIS204
y	MET207

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:28844695, ECO:0007744|PDB:5XTH

Chain	Residue	Details
AH	MET244
AU	MET244
x	VAL287-ASP298

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
AH	SER182
AU	SER182

---

site_id	SWS_FT_FI8
Number of Residues	32
Details	TRANSMEM: Helical; Name=VI => ECO:0000269|PubMed:27605664

Chain	Residue	Details
z	GLY191-LEU223

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664

Chain	Residue	Details
z	PHE233-ILE256

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	TYR270-ILE286

---

site_id	SWS_FT_FI11
Number of Residues	28
Details	TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	VAL299-LEU327

---

site_id	SWS_FT_FI12
Number of Residues	7
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	HIS328-SER335

---

site_id	SWS_FT_FI13
Number of Residues	21
Details	TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	PRO336-VAL357

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	LEU358-THR370
x	SER434-ALA446

---

site_id	SWS_FT_FI15
Number of Residues	29
Details	TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	TYR371-PHE400

---

site_id	SWS_FT_FI16
Number of Residues	26
Details	TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	ASP407-LEU433

---

site_id	SWS_FT_FI17
Number of Residues	31
Details	TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664

Chain	Residue	Details
x	TYR447-SER478

---

site_id	SWS_FT_FI18
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388

Chain	Residue	Details
x	GLU40
x	GLY45
x	SER441

---

site_id	SWS_FT_FI19
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158

Chain	Residue	Details
x	HIS61
x	HIS376
x	HIS378

---

site_id	SWS_FT_FI20
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158

Chain	Residue	Details
x	HIS240
x	HIS290
x	HIS291
x	HIS368
x	ASP369

---

site_id	SWS_FT_FI21
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
x	TYR244

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784

Chain	Residue	Details
x	MET1

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009

Chain	Residue	Details
x	HIS240
x	TYR244

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
x	HIS61	metal ligand
x	HIS290	metal ligand
x	HIS291	metal ligand, proton acceptor, proton donor
x	THR316	proton acceptor, proton donor, proton relay
x	LYS319	proton acceptor, proton donor, proton relay
x	ARG438	proton acceptor, proton donor, proton relay
x	ASP91	proton acceptor, proton donor, proton relay
x	TRP126	proton acceptor, proton donor, proton relay
x	SER156	proton acceptor, proton donor, proton relay
x	SER157	proton acceptor, proton donor, proton relay
x	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
x	GLU242	proton acceptor, proton donor, proton relay
x	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
x	SER255	proton acceptor, proton donor, proton relay

---