Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XOX

Crystal structure of tRNA(His) guanylyltranserase from Saccharomyces cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0008193	molecular_function	tRNA guanylyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0097748	molecular_function	3'-5' RNA polymerase activity
A	0099116	biological_process	tRNA 5'-end processing
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006400	biological_process	tRNA modification
B	0008033	biological_process	tRNA processing
B	0008193	molecular_function	tRNA guanylyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0097748	molecular_function	3'-5' RNA polymerase activity
B	0099116	biological_process	tRNA 5'-end processing
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006400	biological_process	tRNA modification
C	0008033	biological_process	tRNA processing
C	0008193	molecular_function	tRNA guanylyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0097748	molecular_function	3'-5' RNA polymerase activity
C	0099116	biological_process	tRNA 5'-end processing
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006400	biological_process	tRNA modification
D	0008033	biological_process	tRNA processing
D	0008193	molecular_function	tRNA guanylyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0097748	molecular_function	3'-5' RNA polymerase activity
D	0099116	biological_process	tRNA 5'-end processing
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006400	biological_process	tRNA modification
E	0008033	biological_process	tRNA processing
E	0008193	molecular_function	tRNA guanylyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0097748	molecular_function	3'-5' RNA polymerase activity
E	0099116	biological_process	tRNA 5'-end processing
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006400	biological_process	tRNA modification
F	0008033	biological_process	tRNA processing
F	0008193	molecular_function	tRNA guanylyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0097748	molecular_function	3'-5' RNA polymerase activity
F	0099116	biological_process	tRNA 5'-end processing

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue GTP A 301

Chain	Residue
A	ASP29
A	SER76
A	ASP77
A	MG302
A	MG303
A	GLY30
A	LYS32
A	PHE33
A	HIS34
A	SER37
A	LYS44
A	ASP47
A	LEU51

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 302

Chain	Residue
A	ASP29
A	ASP77
A	GTP301

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 303

Chain	Residue
A	ASP29
A	GLY30
A	ASP77
A	GTP301

site_id	AC4
Number of Residues	2
Details	binding site for residue PO4 A 304

Chain	Residue
A	ARG93
B	ARG133

site_id	AC5
Number of Residues	4
Details	binding site for residue PO4 B 301

Chain	Residue
A	ARG133
B	HIS15
B	ARG93
B	LYS96

site_id	AC6
Number of Residues	14
Details	binding site for residue GTP B 302

Chain	Residue
B	ASP29
B	GLY30
B	LYS32
B	PHE33
B	HIS34
B	SER37
B	PHE42
B	LYS44
B	ASN46
B	ASP47
B	LEU51
B	SER76
B	ASP77
B	MG304

site_id	AC7
Number of Residues	1
Details	binding site for residue MG B 303

Chain	Residue
B	GLU75

site_id	AC8
Number of Residues	4
Details	binding site for residue MG B 304

Chain	Residue
B	ASP29
B	GLY30
B	ASP77
B	GTP302

site_id	AC9
Number of Residues	14
Details	binding site for residue GTP C 301

Chain	Residue
C	ASP29
C	GLY30
C	LYS32
C	PHE33
C	HIS34
C	SER37
C	PHE42
C	LYS44
C	ASP47
C	LEU51
C	SER76
C	ASP77
C	MG302
C	MG303

site_id	AD1
Number of Residues	2
Details	binding site for residue MG C 302

Chain	Residue
C	ASP29
C	GTP301

site_id	AD2
Number of Residues	4
Details	binding site for residue MG C 303

Chain	Residue
C	ASP29
C	GLY30
C	ASP77
C	GTP301

site_id	AD3
Number of Residues	3
Details	binding site for residue PO4 C 304

Chain	Residue
C	ARG10
C	ARG93
D	ARG133

site_id	AD4
Number of Residues	5
Details	binding site for residue PO4 D 301

Chain	Residue
C	ARG133
D	ARG10
D	HIS15
D	ARG93
D	LYS96

site_id	AD5
Number of Residues	15
Details	binding site for residue GTP D 302

Chain	Residue
D	ASP29
D	GLY30
D	LYS32
D	PHE33
D	HIS34
D	SER37
D	PHE42
D	LYS44
D	ASN46
D	ASP47
D	LEU51
D	SER76
D	ASP77
D	MG303
D	MG304

site_id	AD6
Number of Residues	4
Details	binding site for residue MG D 303

Chain	Residue
D	ASP29
D	ASP77
D	GLU78
D	GTP302

site_id	AD7
Number of Residues	4
Details	binding site for residue MG D 304

Chain	Residue
D	ASP29
D	GLY30
D	ASP77
D	GTP302

site_id	AD8
Number of Residues	14
Details	binding site for residue GTP E 301

Chain	Residue
E	HIS34
E	SER37
E	PHE42
E	LYS44
E	PRO45
E	ASP47
E	LEU51
E	SER76
E	ASP77
E	MG302
E	MG303
E	ASP29
E	LYS32
E	PHE33

site_id	AD9
Number of Residues	4
Details	binding site for residue MG E 302

Chain	Residue
E	ASP29
E	ASP77
E	GLU78
E	GTP301

site_id	AE1
Number of Residues	4
Details	binding site for residue MG E 303

Chain	Residue
E	ASP29
E	GLY30
E	ASP77
E	GTP301

site_id	AE2
Number of Residues	4
Details	binding site for residue PO4 E 304

Chain	Residue
E	HIS15
E	ARG93
E	LYS96
E	ARG133

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28623126","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XOX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)