5XNC
Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with N4-aminopropylspermidine and 5-methylthioadenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006596 | biological_process | polyamine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006596 | biological_process | polyamine biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006596 | biological_process | polyamine biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006596 | biological_process | polyamine biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006596 | biological_process | polyamine biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue MTA A 401 |
| Chain | Residue |
| A | PHE125 |
| A | ASP206 |
| A | LEU207 |
| A | ASP225 |
| A | PRO227 |
| A | PHE236 |
| A | LEU342 |
| A | TYR343 |
| A | N4P402 |
| A | ASP126 |
| A | GLN127 |
| A | ASP158 |
| A | ASP159 |
| A | ASP179 |
| A | ILE180 |
| A | LEU184 |
| A | PHE205 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue N4P A 402 |
| Chain | Residue |
| A | ASP126 |
| A | GLN127 |
| A | ALA128 |
| A | ASP159 |
| A | ASP160 |
| A | ASP225 |
| A | PRO226 |
| A | GLU228 |
| A | GLY254 |
| A | TYR290 |
| A | TYR295 |
| A | TYR316 |
| A | THR350 |
| A | MTA401 |
| A | HOH532 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | TYR89 |
| B | ALA103 |
| B | PHE104 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | LYS151 |
| A | ASP220 |
| A | GLY248 |
| A | HOH527 |
| A | HOH531 |
| A | HOH620 |
| B | GLU18 |
| B | ARG19 |
| B | GLU22 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | SER26 |
| A | GLY84 |
| A | ARG86 |
| B | GLU149 |
| B | HOH568 |
| B | HOH576 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue FE A 406 |
| Chain | Residue |
| A | CYS91 |
| A | CYS94 |
| B | CYS91 |
| B | CYS94 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 407 |
| Chain | Residue |
| A | ARG266 |
| A | ARG270 |
| B | ASN274 |
| B | GLU275 |
| B | LYS330 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue MTA B 401 |
| Chain | Residue |
| B | PHE125 |
| B | ASP126 |
| B | GLN127 |
| B | ASP158 |
| B | ASP159 |
| B | ASP179 |
| B | ILE180 |
| B | LEU184 |
| B | PHE205 |
| B | ASP206 |
| B | LEU207 |
| B | ARG208 |
| B | ASP225 |
| B | PRO227 |
| B | PHE236 |
| B | LEU342 |
| B | TYR343 |
| B | N4P402 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue N4P B 402 |
| Chain | Residue |
| B | ASP126 |
| B | GLN127 |
| B | ALA128 |
| B | ASP159 |
| B | ASP160 |
| B | ASP225 |
| B | PRO226 |
| B | GLU228 |
| B | GLY254 |
| B | TYR290 |
| B | TYR295 |
| B | TYR316 |
| B | THR350 |
| B | MTA401 |
| B | HOH511 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | HOH592 |
| A | GLY146 |
| A | GLU149 |
| A | HOH555 |
| B | GLU22 |
| B | GLY82 |
| B | GLY84 |
| B | ARG86 |
| site_id | AD2 |
| Number of Residues | 17 |
| Details | binding site for residue MTA C 401 |
| Chain | Residue |
| C | PHE125 |
| C | ASP126 |
| C | GLN127 |
| C | ASP158 |
| C | ASP159 |
| C | ASP179 |
| C | ILE180 |
| C | LEU184 |
| C | PHE205 |
| C | ASP206 |
| C | LEU207 |
| C | ASP225 |
| C | PRO227 |
| C | PHE236 |
| C | LEU342 |
| C | TYR343 |
| C | N4P402 |
| site_id | AD3 |
| Number of Residues | 15 |
| Details | binding site for residue N4P C 402 |
| Chain | Residue |
| C | ASP126 |
| C | GLN127 |
| C | ALA128 |
| C | ASP159 |
| C | ASP160 |
| C | ASP225 |
| C | PRO226 |
| C | GLU228 |
| C | GLY254 |
| C | TYR290 |
| C | TYR295 |
| C | TYR316 |
| C | THR350 |
| C | MTA401 |
| C | HOH517 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue FE C 403 |
| Chain | Residue |
| C | CYS91 |
| C | CYS94 |
| D | CYS91 |
| D | CYS94 |
| site_id | AD5 |
| Number of Residues | 17 |
| Details | binding site for residue MTA D 401 |
| Chain | Residue |
| D | PHE125 |
| D | ASP126 |
| D | GLN127 |
| D | ASP158 |
| D | ASP159 |
| D | ASP179 |
| D | ILE180 |
| D | LEU184 |
| D | PHE205 |
| D | ASP206 |
| D | LEU207 |
| D | ASP225 |
| D | PRO227 |
| D | PHE236 |
| D | LEU342 |
| D | TYR343 |
| D | N4P402 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue N4P D 402 |
| Chain | Residue |
| D | ASP126 |
| D | GLN127 |
| D | ALA128 |
| D | ASP159 |
| D | ASP160 |
| D | ASP225 |
| D | PRO226 |
| D | GLU228 |
| D | GLY254 |
| D | TYR290 |
| D | TYR295 |
| D | TYR316 |
| D | THR350 |
| D | MTA401 |
| D | HOH536 |
| site_id | AD7 |
| Number of Residues | 8 |
| Details | binding site for residue GOL D 403 |
| Chain | Residue |
| C | ARG19 |
| C | GLU22 |
| D | LYS151 |
| D | ASP220 |
| D | GLY248 |
| D | HOH528 |
| D | HOH560 |
| D | HOH564 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 404 |
| Chain | Residue |
| C | GLU327 |
| D | LYS9 |
| D | PRO15 |
| D | VAL16 |
| D | TYR17 |
| D | HOH514 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 405 |
| Chain | Residue |
| D | PRO212 |
| D | ASP213 |
| D | TYR214 |
| site_id | AE1 |
| Number of Residues | 19 |
| Details | binding site for residue MTA E 401 |
| Chain | Residue |
| E | PHE125 |
| E | ASP126 |
| E | GLN127 |
| E | GLY157 |
| E | ASP158 |
| E | ASP159 |
| E | ASP179 |
| E | ILE180 |
| E | LEU184 |
| E | PHE205 |
| E | ASP206 |
| E | LEU207 |
| E | ARG208 |
| E | ASP225 |
| E | PRO227 |
| E | PHE236 |
| E | LEU342 |
| E | TYR343 |
| E | N4P402 |
| site_id | AE2 |
| Number of Residues | 15 |
| Details | binding site for residue N4P E 402 |
| Chain | Residue |
| E | ASP126 |
| E | GLN127 |
| E | ALA128 |
| E | ASP159 |
| E | ASP160 |
| E | ASP225 |
| E | PRO226 |
| E | GLU228 |
| E | GLY254 |
| E | TYR290 |
| E | TYR295 |
| E | TYR316 |
| E | THR350 |
| E | MTA401 |
| E | HOH508 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue FE E 403 |
| Chain | Residue |
| E | CYS91 |
| E | CYS94 |
| F | CYS91 |
| F | CYS94 |
| site_id | AE4 |
| Number of Residues | 17 |
| Details | binding site for residue MTA F 401 |
| Chain | Residue |
| F | PHE125 |
| F | ASP126 |
| F | GLN127 |
| F | ASP158 |
| F | ASP159 |
| F | ASP179 |
| F | ILE180 |
| F | LEU184 |
| F | PHE205 |
| F | ASP206 |
| F | LEU207 |
| F | ASP225 |
| F | PRO227 |
| F | PHE236 |
| F | LEU342 |
| F | TYR343 |
| F | N4P402 |
| site_id | AE5 |
| Number of Residues | 14 |
| Details | binding site for residue N4P F 402 |
| Chain | Residue |
| F | ASP126 |
| F | ALA128 |
| F | ASP159 |
| F | ASP160 |
| F | ASP225 |
| F | PRO226 |
| F | GLU228 |
| F | GLY254 |
| F | TYR290 |
| F | TYR295 |
| F | TYR316 |
| F | THR350 |
| F | MTA401 |
| F | HOH515 |
| site_id | AE6 |
| Number of Residues | 15 |
| Details | binding site for residue MTA G 401 |
| Chain | Residue |
| G | PHE125 |
| G | ASP126 |
| G | GLN127 |
| G | ASP158 |
| G | ASP159 |
| G | ASP179 |
| G | ILE180 |
| G | LEU184 |
| G | PHE205 |
| G | ASP206 |
| G | LEU207 |
| G | ASP225 |
| G | PHE236 |
| G | TYR343 |
| G | N4P402 |
| site_id | AE7 |
| Number of Residues | 13 |
| Details | binding site for residue N4P G 402 |
| Chain | Residue |
| G | ASP126 |
| G | ALA128 |
| G | ASP159 |
| G | ASP160 |
| G | ASP225 |
| G | PRO226 |
| G | GLU228 |
| G | GLY254 |
| G | TYR290 |
| G | TYR295 |
| G | TYR316 |
| G | THR350 |
| G | MTA401 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue FE G 403 |
| Chain | Residue |
| G | CYS91 |
| G | CYS91 |
| G | CYS94 |
| G | CYS94 |
