5XMC

Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Weqrvdqhgrv.YYvdhvekrTTWDRP

Chain	Residue	Details
A	TRP293-PRO318
A	TRP325-PRO350
A	TRP405-PRO430
A	TRP445-PRO470

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Domain: {"description":"WW 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00224","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	33
Details	Domain: {"description":"WW 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00224","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00104","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by SGK3","evidences":[{"source":"UniProtKB","id":"Q96J02","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by FYN","evidences":[{"source":"UniProtKB","id":"Q96J02","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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