5XMC

Crystal structure of the auto-inhibited Nedd4 family E3 ligase Itch

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0061630	molecular_function	ubiquitin protein ligase activity

Functional Information from PROSITE/UniProt

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Weqrvdqhgrv.YYvdhvekrTTWDRP

Chain	Residue	Details
A	TRP293-PRO318
A	TRP325-PRO350
A	TRP405-PRO430
A	TRP445-PRO470

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00104

Chain	Residue	Details
A	CYS832

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:16446428

Chain	Residue	Details
A	SER199
A	SER232

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by MAPK8 => ECO:0000269|PubMed:16446428

Chain	Residue	Details
A	THR222

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by SGK3 => ECO:0000250|UniProtKB:Q96J02

Chain	Residue	Details
A	THR346

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by FYN => ECO:0000250|UniProtKB:Q96J02

Chain	Residue	Details
A	TYR381

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by SGK3 => ECO:0000250|UniProtKB:Q96J02

Chain	Residue	Details
A	SER411

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