5XJV
Two intermediate states of conformation switch in dual specificity phosphatase 13a
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0008138 | molecular_function | protein tyrosine/serine/threonine phosphatase activity |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0008138 | molecular_function | protein tyrosine/serine/threonine phosphatase activity |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 A 201 |
| Chain | Residue |
| A | ASP97 |
| A | HOH412 |
| A | SER129 |
| A | VAL130 |
| A | VAL131 |
| A | GLY132 |
| A | VAL133 |
| A | SER134 |
| A | ARG135 |
| A | HOH308 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 201 |
| Chain | Residue |
| B | ASP97 |
| B | SER129 |
| B | VAL130 |
| B | VAL131 |
| B | GLY132 |
| B | VAL133 |
| B | SER134 |
| B | ARG135 |
| B | HOH401 |
| B | HOH422 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 294 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29106959","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
