5XGK

Crystal structure of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD) complexed with its substrate 4-hydroxyphenylpyruvate acid (HPPA)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006572	biological_process	L-tyrosine catabolic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0009507	cellular_component	chloroplast
A	0010189	biological_process	vitamin E biosynthetic process
A	0010236	biological_process	plastoquinone biosynthetic process
A	0016117	biological_process	carotenoid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
B	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006572	biological_process	L-tyrosine catabolic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0009507	cellular_component	chloroplast
B	0010189	biological_process	vitamin E biosynthetic process
B	0010236	biological_process	plastoquinone biosynthetic process
B	0016117	biological_process	carotenoid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051213	molecular_function	dioxygenase activity
C	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006572	biological_process	L-tyrosine catabolic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0009507	cellular_component	chloroplast
C	0010189	biological_process	vitamin E biosynthetic process
C	0010236	biological_process	plastoquinone biosynthetic process
C	0016117	biological_process	carotenoid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
D	0003868	molecular_function	4-hydroxyphenylpyruvate dioxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005576	cellular_component	extracellular region
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006572	biological_process	L-tyrosine catabolic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0009507	cellular_component	chloroplast
D	0010189	biological_process	vitamin E biosynthetic process
D	0010236	biological_process	plastoquinone biosynthetic process
D	0016117	biological_process	carotenoid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016701	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue TYF A 501

Chain	Residue
A	HIS226
A	FE502
A	HOH601
A	VAL228
A	HIS308
A	GLN379
A	PHE381
A	GLU394
A	PHE419
A	GLY420
A	ASN423

---

site_id	AC2
Number of Residues	5
Details	binding site for residue FE A 502

Chain	Residue
A	HIS226
A	HIS308
A	GLU394
A	TYF501
A	HOH601

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ACT A 503

Chain	Residue
A	HIS300
A	ARG388
B	TYR103
B	SER104
B	LEU107

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ACT A 504

Chain	Residue
A	ALA61
A	ARG62
A	PHE72

---

site_id	AC5
Number of Residues	3
Details	binding site for residue FE B 501

Chain	Residue
B	HIS226
B	HIS308
B	GLU394

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ACT B 502

Chain	Residue
B	ALA61
B	ARG62
B	PHE72
B	TYR88

---

site_id	AC7
Number of Residues	4
Details	binding site for residue FE C 501

Chain	Residue
C	HIS226
C	HIS308
C	GLU394
C	HOH613

---

site_id	AC8
Number of Residues	4
Details	binding site for residue FE D 501

Chain	Residue
D	HIS226
D	HIS308
D	GLU394
D	HOH649

---

site_id	AC9
Number of Residues	5
Details	binding site for residue ACT D 502

Chain	Residue
D	GLU252
D	GLY418
D	PHE419
D	GLY420
D	LYS421

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15301540","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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