5XEN
Crystal structure of a hydrogen sulfide-producing enzyme (Fn1220) from Fusobacterium nucleatum in complex with L-serine-PLP Schiff base
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue PLP A 401 |
| Chain | Residue |
| A | LYS42 |
| A | SER266 |
| A | THR293 |
| A | ASP294 |
| A | SER402 |
| A | PLP403 |
| A | HOH515 |
| A | HOH519 |
| A | HOH527 |
| A | HOH547 |
| A | HOH573 |
| A | ASN72 |
| A | THR175 |
| A | GLY176 |
| A | THR177 |
| A | GLY178 |
| A | GLY179 |
| A | SER180 |
| A | GLY220 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SER A 402 |
| Chain | Residue |
| A | LYS42 |
| A | THR69 |
| A | SER70 |
| A | ASN72 |
| A | THR73 |
| A | GLN142 |
| A | GLY220 |
| A | PLP401 |
| A | PLP403 |
| A | HOH656 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue PLP A 403 |
| Chain | Residue |
| A | LYS42 |
| A | ASN72 |
| A | THR175 |
| A | GLY176 |
| A | THR177 |
| A | GLY178 |
| A | SER180 |
| A | GLN219 |
| A | GLY220 |
| A | SER266 |
| A | THR293 |
| A | ASP294 |
| A | TYR299 |
| A | PLP401 |
| A | SER402 |
| A | HOH515 |
| A | HOH519 |
| A | HOH527 |
| A | HOH547 |
| A | HOH573 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue ACT A 404 |
| Chain | Residue |
| A | TYR86 |
| A | LEU88 |
| A | TYR107 |
| A | GLY108 |
| A | CA405 |
| A | CA410 |
| A | HOH588 |
| A | HOH654 |
| A | HOH663 |
| B | ASP283 |
| B | HOH603 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 405 |
| Chain | Residue |
| A | GLY108 |
| A | ACT404 |
| A | HOH588 |
| A | HOH654 |
| A | HOH666 |
| B | ASP283 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CA A 406 |
| Chain | Residue |
| A | HOH598 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 407 |
| Chain | Residue |
| A | GLU56 |
| A | HOH567 |
| A | HOH609 |
| A | HOH614 |
| A | HOH670 |
| B | GLU110 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 408 |
| Chain | Residue |
| A | ASP246 |
| A | HOH506 |
| A | HOH694 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue PEG A 409 |
| Chain | Residue |
| A | TYR153 |
| A | LYS186 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 410 |
| Chain | Residue |
| A | ACT404 |
| A | HOH536 |
| A | HOH610 |
| A | HOH663 |
| A | HOH682 |
| B | HOH516 |
| B | HOH603 |
| site_id | AD2 |
| Number of Residues | 10 |
| Details | binding site for residue SER B 402 |
| Chain | Residue |
| B | LYS42 |
| B | THR69 |
| B | SER70 |
| B | ASN72 |
| B | THR73 |
| B | GLN142 |
| B | GLY220 |
| B | PLP401 |
| B | PLP403 |
| B | ACT404 |
| site_id | AD3 |
| Number of Residues | 22 |
| Details | binding site for residue PLP B 403 |
| Chain | Residue |
| B | THR177 |
| B | GLY178 |
| B | GLY179 |
| B | SER180 |
| B | GLN219 |
| B | GLY220 |
| B | SER266 |
| B | THR293 |
| B | ASP294 |
| B | TYR299 |
| B | PLP401 |
| B | SER402 |
| B | ACT404 |
| B | HOH507 |
| B | HOH525 |
| B | HOH526 |
| B | HOH566 |
| B | HOH606 |
| B | LYS42 |
| B | ASN72 |
| B | THR175 |
| B | GLY176 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue ACT B 404 |
| Chain | Residue |
| B | LYS42 |
| B | THR69 |
| B | SER70 |
| B | ASN72 |
| B | THR73 |
| B | GLN142 |
| B | PLP401 |
| B | SER402 |
| B | PLP403 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 405 |
| Chain | Residue |
| B | GLU244 |
| B | GLU244 |
| B | ASP246 |
| B | HOH530 |
| B | HOH669 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 406 |
| Chain | Residue |
| B | GLU190 |
| B | HOH509 |
| B | HOH554 |
| B | HOH699 |
| B | HOH716 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 407 |
| Chain | Residue |
| B | ASP238 |
| B | HOH582 |
| B | HOH594 |
| B | HOH695 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 408 |
| Chain | Residue |
| B | VAL146 |
| B | LYS150 |
| B | LYS186 |
| B | HOH685 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 409 |
| Chain | Residue |
| B | SER117 |
| B | SER224 |
| B | HOH718 |
| site_id | AE1 |
| Number of Residues | 27 |
| Details | binding site for Di-peptide PLP B 401 and LYS B 42 |
| Chain | Residue |
| B | SER40 |
| B | THR41 |
| B | ASP43 |
| B | ARG44 |
| B | ILE45 |
| B | ALA46 |
| B | ASN72 |
| B | THR73 |
| B | THR175 |
| B | GLY176 |
| B | THR177 |
| B | GLY178 |
| B | GLY179 |
| B | SER180 |
| B | GLY220 |
| B | SER266 |
| B | THR293 |
| B | ASP294 |
| B | TYR299 |
| B | SER402 |
| B | PLP403 |
| B | ACT404 |
| B | HOH507 |
| B | HOH525 |
| B | HOH526 |
| B | HOH566 |
| B | HOH606 |
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LgGIStGAtfkaaldYskEnadkglK |
| Chain | Residue | Details |
| A | LEU262-LYS287 |
