5XEM
Crystal structure of a hydrogen sulfide-producing enzyme (Fn1220) from Fusobacterium nucleatum in complex with L-lanthionine-PLP Schiff base
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004124 | molecular_function | cysteine synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006534 | biological_process | cysteine metabolic process |
A | 0006535 | biological_process | cysteine biosynthetic process from serine |
A | 0009069 | biological_process | serine family amino acid metabolic process |
A | 0016740 | molecular_function | transferase activity |
A | 0044272 | biological_process | sulfur compound biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
B | 0004124 | molecular_function | cysteine synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006534 | biological_process | cysteine metabolic process |
B | 0006535 | biological_process | cysteine biosynthetic process from serine |
B | 0009069 | biological_process | serine family amino acid metabolic process |
B | 0016740 | molecular_function | transferase activity |
B | 0044272 | biological_process | sulfur compound biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue ACT A 503 |
Chain | Residue |
A | TYR86 |
A | LEU88 |
A | GLY108 |
A | CA505 |
A | CA513 |
A | HOH649 |
B | ASP283 |
B | HOH520 |
B | HOH560 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue ACT A 504 |
Chain | Residue |
A | LYS131 |
A | VAL139 |
A | ASN141 |
A | HOH606 |
A | HOH754 |
B | LYS136 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA A 505 |
Chain | Residue |
A | GLY108 |
A | ACT503 |
A | HOH649 |
A | HOH757 |
A | HOH763 |
B | ASP283 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue CA A 506 |
Chain | Residue |
A | HOH735 |
A | HOH748 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue CA A 507 |
Chain | Residue |
A | GLU56 |
A | HOH654 |
A | HOH675 |
A | HOH722 |
A | HOH765 |
B | GLU110 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue CA A 508 |
Chain | Residue |
A | ASP246 |
A | HOH616 |
A | HOH658 |
A | HOH799 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue CA A 509 |
Chain | Residue |
A | HOH620 |
A | HOH687 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue CA A 510 |
Chain | Residue |
A | LEU300 |
A | SER301 |
B | GLN102 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue PEG A 511 |
Chain | Residue |
A | LYS150 |
A | TYR153 |
A | LYS186 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue PG0 A 512 |
Chain | Residue |
A | ASP247 |
A | GLU250 |
A | MET251 |
A | LYS272 |
A | ASP276 |
A | HOH771 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue CA A 513 |
Chain | Residue |
A | ACT503 |
A | HOH639 |
A | HOH699 |
A | HOH773 |
A | HOH778 |
B | HOH520 |
B | HOH560 |
site_id | AD3 |
Number of Residues | 20 |
Details | binding site for residue 85F B 402 |
Chain | Residue |
B | LYS42 |
B | THR69 |
B | SER70 |
B | ASN72 |
B | THR73 |
B | MET120 |
B | GLN142 |
B | GLY176 |
B | THR177 |
B | GLY220 |
B | MET221 |
B | GLY222 |
B | MET223 |
B | SER224 |
B | PLP401 |
B | PLP403 |
B | ACT404 |
B | HOH551 |
B | HOH650 |
B | HOH663 |
site_id | AD4 |
Number of Residues | 20 |
Details | binding site for residue PLP B 403 |
Chain | Residue |
B | LYS42 |
B | ASN72 |
B | THR175 |
B | GLY176 |
B | THR177 |
B | GLY178 |
B | SER180 |
B | GLN219 |
B | GLY220 |
B | SER266 |
B | THR293 |
B | ASP294 |
B | TYR299 |
B | PLP401 |
B | 85F402 |
B | ACT404 |
B | HOH513 |
B | HOH519 |
B | HOH524 |
B | HOH580 |
site_id | AD5 |
Number of Residues | 9 |
Details | binding site for residue ACT B 404 |
Chain | Residue |
B | GLN142 |
B | PLP401 |
B | 85F402 |
B | PLP403 |
B | LYS42 |
B | THR69 |
B | SER70 |
B | ASN72 |
B | THR73 |
site_id | AD6 |
Number of Residues | 5 |
Details | binding site for residue CA B 405 |
Chain | Residue |
B | GLU244 |
B | GLU244 |
B | ASP246 |
B | HOH530 |
B | HOH669 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue CA B 406 |
Chain | Residue |
B | GLU190 |
B | HOH521 |
B | HOH586 |
B | HOH687 |
B | HOH702 |
site_id | AD8 |
Number of Residues | 2 |
Details | binding site for residue CA B 407 |
Chain | Residue |
B | ASP238 |
B | HOH576 |
site_id | AD9 |
Number of Residues | 3 |
Details | binding site for residue CA B 408 |
Chain | Residue |
A | HOH642 |
B | GLY57 |
B | HOH708 |
site_id | AE1 |
Number of Residues | 4 |
Details | binding site for residue CA B 409 |
Chain | Residue |
B | HOH571 |
B | HOH664 |
B | HOH677 |
B | HOH698 |
site_id | AE2 |
Number of Residues | 2 |
Details | binding site for residue PEG B 410 |
Chain | Residue |
B | VAL146 |
B | LYS186 |
site_id | AE3 |
Number of Residues | 6 |
Details | binding site for residue PG5 B 411 |
Chain | Residue |
B | SER117 |
B | LEU118 |
B | LYS121 |
B | ILE213 |
B | SER224 |
B | HOH705 |
site_id | AE4 |
Number of Residues | 30 |
Details | binding site for residues 85F A 501 and PLP A 502 |
Chain | Residue |
A | LYS42 |
A | THR69 |
A | SER70 |
A | ASN72 |
A | THR73 |
A | MET120 |
A | GLN142 |
A | THR175 |
A | GLY176 |
A | THR177 |
A | GLY178 |
A | GLY179 |
A | SER180 |
A | GLN219 |
A | GLY220 |
A | MET221 |
A | GLY222 |
A | MET223 |
A | SER224 |
A | SER266 |
A | THR293 |
A | ASP294 |
A | TYR299 |
A | HOH621 |
A | HOH651 |
A | HOH668 |
A | HOH672 |
A | HOH706 |
A | HOH715 |
A | HOH740 |
site_id | AE5 |
Number of Residues | 26 |
Details | binding site for Di-peptide PLP B 401 and LYS B 42 |
Chain | Residue |
B | SER40 |
B | THR41 |
B | ASP43 |
B | ARG44 |
B | ILE45 |
B | ALA46 |
B | ASN72 |
B | THR73 |
B | GLN142 |
B | THR175 |
B | GLY176 |
B | THR177 |
B | GLY178 |
B | GLY179 |
B | SER180 |
B | GLY220 |
B | SER266 |
B | THR293 |
B | ASP294 |
B | 85F402 |
B | PLP403 |
B | ACT404 |
B | HOH513 |
B | HOH519 |
B | HOH524 |
B | HOH580 |
Functional Information from PROSITE/UniProt
site_id | PS00217 |
Number of Residues | 26 |
Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LgGIStGAtfkaaldYskEnadkglK |
Chain | Residue | Details |
A | LEU262-LYS287 |