5XEM
Crystal structure of a hydrogen sulfide-producing enzyme (Fn1220) from Fusobacterium nucleatum in complex with L-lanthionine-PLP Schiff base
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| A | 1901605 | biological_process | alpha-amino acid metabolic process |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue ACT A 503 |
| Chain | Residue |
| A | TYR86 |
| A | LEU88 |
| A | GLY108 |
| A | CA505 |
| A | CA513 |
| A | HOH649 |
| B | ASP283 |
| B | HOH520 |
| B | HOH560 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 504 |
| Chain | Residue |
| A | LYS131 |
| A | VAL139 |
| A | ASN141 |
| A | HOH606 |
| A | HOH754 |
| B | LYS136 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 505 |
| Chain | Residue |
| A | GLY108 |
| A | ACT503 |
| A | HOH649 |
| A | HOH757 |
| A | HOH763 |
| B | ASP283 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 506 |
| Chain | Residue |
| A | HOH735 |
| A | HOH748 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 507 |
| Chain | Residue |
| A | GLU56 |
| A | HOH654 |
| A | HOH675 |
| A | HOH722 |
| A | HOH765 |
| B | GLU110 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 508 |
| Chain | Residue |
| A | ASP246 |
| A | HOH616 |
| A | HOH658 |
| A | HOH799 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 509 |
| Chain | Residue |
| A | HOH620 |
| A | HOH687 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 510 |
| Chain | Residue |
| A | LEU300 |
| A | SER301 |
| B | GLN102 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 511 |
| Chain | Residue |
| A | LYS150 |
| A | TYR153 |
| A | LYS186 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PG0 A 512 |
| Chain | Residue |
| A | ASP247 |
| A | GLU250 |
| A | MET251 |
| A | LYS272 |
| A | ASP276 |
| A | HOH771 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 513 |
| Chain | Residue |
| A | ACT503 |
| A | HOH639 |
| A | HOH699 |
| A | HOH773 |
| A | HOH778 |
| B | HOH520 |
| B | HOH560 |
| site_id | AD3 |
| Number of Residues | 20 |
| Details | binding site for residue 85F B 402 |
| Chain | Residue |
| B | LYS42 |
| B | THR69 |
| B | SER70 |
| B | ASN72 |
| B | THR73 |
| B | MET120 |
| B | GLN142 |
| B | GLY176 |
| B | THR177 |
| B | GLY220 |
| B | MET221 |
| B | GLY222 |
| B | MET223 |
| B | SER224 |
| B | PLP401 |
| B | PLP403 |
| B | ACT404 |
| B | HOH551 |
| B | HOH650 |
| B | HOH663 |
| site_id | AD4 |
| Number of Residues | 20 |
| Details | binding site for residue PLP B 403 |
| Chain | Residue |
| B | LYS42 |
| B | ASN72 |
| B | THR175 |
| B | GLY176 |
| B | THR177 |
| B | GLY178 |
| B | SER180 |
| B | GLN219 |
| B | GLY220 |
| B | SER266 |
| B | THR293 |
| B | ASP294 |
| B | TYR299 |
| B | PLP401 |
| B | 85F402 |
| B | ACT404 |
| B | HOH513 |
| B | HOH519 |
| B | HOH524 |
| B | HOH580 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue ACT B 404 |
| Chain | Residue |
| B | GLN142 |
| B | PLP401 |
| B | 85F402 |
| B | PLP403 |
| B | LYS42 |
| B | THR69 |
| B | SER70 |
| B | ASN72 |
| B | THR73 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 405 |
| Chain | Residue |
| B | GLU244 |
| B | GLU244 |
| B | ASP246 |
| B | HOH530 |
| B | HOH669 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 406 |
| Chain | Residue |
| B | GLU190 |
| B | HOH521 |
| B | HOH586 |
| B | HOH687 |
| B | HOH702 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue CA B 407 |
| Chain | Residue |
| B | ASP238 |
| B | HOH576 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 408 |
| Chain | Residue |
| A | HOH642 |
| B | GLY57 |
| B | HOH708 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 409 |
| Chain | Residue |
| B | HOH571 |
| B | HOH664 |
| B | HOH677 |
| B | HOH698 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 410 |
| Chain | Residue |
| B | VAL146 |
| B | LYS186 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue PG5 B 411 |
| Chain | Residue |
| B | SER117 |
| B | LEU118 |
| B | LYS121 |
| B | ILE213 |
| B | SER224 |
| B | HOH705 |
| site_id | AE4 |
| Number of Residues | 30 |
| Details | binding site for residues 85F A 501 and PLP A 502 |
| Chain | Residue |
| A | LYS42 |
| A | THR69 |
| A | SER70 |
| A | ASN72 |
| A | THR73 |
| A | MET120 |
| A | GLN142 |
| A | THR175 |
| A | GLY176 |
| A | THR177 |
| A | GLY178 |
| A | GLY179 |
| A | SER180 |
| A | GLN219 |
| A | GLY220 |
| A | MET221 |
| A | GLY222 |
| A | MET223 |
| A | SER224 |
| A | SER266 |
| A | THR293 |
| A | ASP294 |
| A | TYR299 |
| A | HOH621 |
| A | HOH651 |
| A | HOH668 |
| A | HOH672 |
| A | HOH706 |
| A | HOH715 |
| A | HOH740 |
| site_id | AE5 |
| Number of Residues | 26 |
| Details | binding site for Di-peptide PLP B 401 and LYS B 42 |
| Chain | Residue |
| B | SER40 |
| B | THR41 |
| B | ASP43 |
| B | ARG44 |
| B | ILE45 |
| B | ALA46 |
| B | ASN72 |
| B | THR73 |
| B | GLN142 |
| B | THR175 |
| B | GLY176 |
| B | THR177 |
| B | GLY178 |
| B | GLY179 |
| B | SER180 |
| B | GLY220 |
| B | SER266 |
| B | THR293 |
| B | ASP294 |
| B | 85F402 |
| B | PLP403 |
| B | ACT404 |
| B | HOH513 |
| B | HOH519 |
| B | HOH524 |
| B | HOH580 |
Functional Information from PROSITE/UniProt
| site_id | PS00217 |
| Number of Residues | 26 |
| Details | SUGAR_TRANSPORT_2 Sugar transport proteins signature 2. LgGIStGAtfkaaldYskEnadkglK |
| Chain | Residue | Details |
| A | LEU262-LYS287 |
