Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XDQ

Bovine heart cytochrome c oxidase in the fully oxidized state with pH 7.3 at 1.77 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0008535	biological_process	respiratory chain complex IV assembly
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	1902600	biological_process	proton transmembrane transport
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0045277	cellular_component	respiratory chain complex IV
E	0005743	cellular_component	mitochondrial inner membrane
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0045277	cellular_component	respiratory chain complex IV
F	0005740	cellular_component	mitochondrial envelope
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0045277	cellular_component	respiratory chain complex IV
G	0005743	cellular_component	mitochondrial inner membrane
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0016020	cellular_component	membrane
H	0045277	cellular_component	respiratory chain complex IV
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006119	biological_process	oxidative phosphorylation
I	0016020	cellular_component	membrane
I	0045277	cellular_component	respiratory chain complex IV
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0045277	cellular_component	respiratory chain complex IV
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0045277	cellular_component	respiratory chain complex IV
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0045277	cellular_component	respiratory chain complex IV
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006119	biological_process	oxidative phosphorylation
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0020037	molecular_function	heme binding
N	0022904	biological_process	respiratory electron transport chain
N	0045277	cellular_component	respiratory chain complex IV
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005507	molecular_function	copper ion binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0022900	biological_process	electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0042773	biological_process	ATP synthesis coupled electron transport
O	0045277	cellular_component	respiratory chain complex IV
O	0046872	molecular_function	metal ion binding
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0008535	biological_process	respiratory chain complex IV assembly
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0019646	biological_process	aerobic electron transport chain
P	0022904	biological_process	respiratory electron transport chain
P	0045277	cellular_component	respiratory chain complex IV
P	1902600	biological_process	proton transmembrane transport
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Q	0045277	cellular_component	respiratory chain complex IV
R	0005743	cellular_component	mitochondrial inner membrane
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0045277	cellular_component	respiratory chain complex IV
S	0005740	cellular_component	mitochondrial envelope
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0045277	cellular_component	respiratory chain complex IV
T	0005743	cellular_component	mitochondrial inner membrane
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006119	biological_process	oxidative phosphorylation
U	0016020	cellular_component	membrane
U	0045277	cellular_component	respiratory chain complex IV
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006119	biological_process	oxidative phosphorylation
V	0016020	cellular_component	membrane
V	0045277	cellular_component	respiratory chain complex IV
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
W	0045277	cellular_component	respiratory chain complex IV
X	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0045277	cellular_component	respiratory chain complex IV
Z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Z	0045277	cellular_component	respiratory chain complex IV

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	binding site for residue HEA A 601

Chain	Residue
A	ALA24
A	HIS61
A	ALA62
A	MET65
A	VAL70
A	ILE73
A	GLY125
A	TRP126
A	TYR371
A	PHE377
A	HIS378
A	GLY27
A	SER382
A	VAL386
A	PHE393
A	MET417
A	PHE425
A	GLN428
A	ARG438
A	ARG439
A	TYR440
A	VAL465
A	MET28
A	MET468
A	EDO619
A	HOH715
A	HOH743
A	HOH750
A	THR31
A	SER34
A	ILE37
A	ARG38
A	TYR54
A	VAL58

site_id	AC2
Number of Residues	30
Details	binding site for residue HEA A 602

Chain	Residue
A	TRP126
A	TRP236
A	VAL243
A	TYR244
A	HIS290
A	HIS291
A	THR309
A	ILE312
A	THR316
A	GLY317
A	GLY352
A	LEU353
A	GLY355
A	ILE356
A	LEU358
A	ALA359
A	ASP364
A	HIS368
A	VAL373
A	HIS376
A	PHE377
A	VAL380
A	LEU381
A	ARG438
A	PER607
A	HOH736
A	HOH742
A	HOH809
A	HOH844
B	ILE34

site_id	AC3
Number of Residues	4
Details	binding site for residue CU A 603

Chain	Residue
A	HIS240
A	HIS290
A	HIS291
A	PER607

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	HIS368
A	ASP369
B	GLU198
B	HOH402
B	HOH427
B	HOH553

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 605

Chain	Residue
A	GLU40
A	GLY45
A	SER441
A	HOH863

site_id	AC6
Number of Residues	13
Details	binding site for residue PGV A 606

Chain	Residue
A	ASN406
A	THR408
A	ARG480
A	HOH711
A	HOH908
D	PHE87
K	PHE9
K	HOH116
M	LYS4
M	PRO5
M	GLN15
M	LEU19
M	SER20

site_id	AC7
Number of Residues	6
Details	binding site for residue PER A 607

Chain	Residue
A	HIS240
A	VAL243
A	HIS290
A	HIS291
A	HEA602
A	CU603

site_id	AC8
Number of Residues	19
Details	binding site for residue PGV A 608

Chain	Residue
A	ARG96
A	MET97
A	PHE148
A	HOH728
A	HOH793
C	HIS9
C	GLY20
C	ALA24
C	ASN50
C	TRP57
C	TRP58
C	VAL61
C	GLU64
C	HIS71
C	GLY82
C	GLU90
C	PEK303
A	PHE94
A	PRO95

site_id	AC9
Number of Residues	8
Details	binding site for residue EDO A 609

Chain	Residue
A	ARG5
A	ASN11
A	LYS13
A	ASP14
A	TRP81
A	PRO500
A	TYR502
L	ASN10

site_id	AD1
Number of Residues	7
Details	binding site for residue EDO A 610

Chain	Residue
A	HIS256
A	LYS265
A	THR490
A	ASN491
A	HOH717
A	HOH772
A	HOH853

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO A 611

Chain	Residue
A	CYS498
A	EDO615
A	HOH747
D	SER8
D	TYR11
D	HOH387

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO A 612

Chain	Residue
A	LEU483
A	VAL485
A	TRP494
A	GLY497
A	CYS498
A	EDO615
A	HOH803

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO A 613

Chain	Residue
A	TYR260
A	TYR261
A	HIS395
A	TRP494
A	HOH709
A	HOH719
M	ILE1

site_id	AD5
Number of Residues	8
Details	binding site for residue EDO A 614

Chain	Residue
A	TYR261
A	LYS333
A	SER335
A	ASP407
A	HOH709
A	HOH734
A	HOH875
M	ILE1

site_id	AD6
Number of Residues	9
Details	binding site for residue EDO A 615

Chain	Residue
A	VAL482
A	LEU483
A	GLY497
A	CYS498
A	EDO611
A	EDO612
A	HOH706
D	SER8
D	TYR11

site_id	AD7
Number of Residues	1
Details	binding site for residue EDO A 616

Chain	Residue
A	GLU119

site_id	AD8
Number of Residues	7
Details	binding site for residue EDO A 617

Chain	Residue
A	PRO131
A	ASP221
A	HOH718
A	HOH730
A	HOH758
A	HOH796
B	EDO306

site_id	AD9
Number of Residues	3
Details	binding site for residue EDO A 618

Chain	Residue
A	THR489
A	HOH729
F	ILE70

site_id	AE1
Number of Residues	7
Details	binding site for residue EDO A 619

Chain	Residue
A	MET390
A	HIS413
A	MET417
A	ALA464
A	VAL465
A	MET468
A	HEA601

site_id	AE2
Number of Residues	14
Details	binding site for residue TGL B 301

Chain	Residue
A	VAL350
A	ASN422
A	PHE426
A	HIS429
A	PHE430
A	LEU433
B	LEU7
B	GLY8
B	HIS24
B	LEU28
B	PHE32
B	SER35
B	HOH465
I	ARG43

site_id	AE3
Number of Residues	6
Details	binding site for residue CUA B 302

Chain	Residue
B	HIS161
B	CYS196
B	GLU198
B	CYS200
B	HIS204
B	MET207

site_id	AE4
Number of Residues	15
Details	binding site for residue PSC B 303

Chain	Residue
A	PHE321
A	LEU324
A	HIS328
A	HOH763
B	ILE41
B	HIS52
B	MET56
B	ASP57
B	TRP65
E	HIS5
E	GLU6
E	ASP8
E	ASP40
E	HOH363
E	HOH376

site_id	AE5
Number of Residues	13
Details	binding site for residue CHD B 304

Chain	Residue
A	MET271
B	GLN59
B	GLU62
B	THR63
B	THR66
B	HOH433
B	HOH562
T	ARG14
T	ARG17
T	PHE21
T	GLY22
T	PEK102
T	HOH217

site_id	AE6
Number of Residues	7
Details	binding site for residue EDO B 305

Chain	Residue
A	TYR447
B	ALA2
B	GLN10
B	PRO166
B	TYR193
B	HOH445
B	HOH477

site_id	AE7
Number of Residues	9
Details	binding site for residue EDO B 306

Chain	Residue
A	LEU136
A	ALA137
A	EDO617
A	HOH718
B	ASP158
B	HOH408
B	HOH423
B	HOH424
B	HOH544

site_id	AE8
Number of Residues	5
Details	binding site for residue EDO B 307

Chain	Residue
B	GLU157
B	HOH422
B	HOH423
B	HOH472
H	EDO101

site_id	AE9
Number of Residues	4
Details	binding site for residue EDO B 308

Chain	Residue
A	HOH724
B	PHE206
B	HOH418
B	HOH435

site_id	AF1
Number of Residues	4
Details	binding site for residue EDO B 309

Chain	Residue
B	HIS102
B	GLU157
B	ASP158
B	HOH456

site_id	AF2
Number of Residues	13
Details	binding site for residue CHD C 301

Chain	Residue
A	HIS233
A	ASP300
A	THR301
A	TYR304
A	HOH807
C	TRP99
C	HIS103
C	PGV306
C	HOH452
C	HOH457
C	HOH458
C	HOH507
P	LEU127

site_id	AF3
Number of Residues	4
Details	binding site for residue NA C 302

Chain	Residue
C	HIS148
C	HIS232
C	GLU236
C	HOH516

site_id	AF4
Number of Residues	21
Details	binding site for residue PEK C 303

Chain	Residue
A	HIS151
A	ALA203
A	LEU215
A	PGV608
C	TRP34
C	TYR181
C	TYR182
C	ALA184
C	PHE186
C	THR187
C	ILE188
C	PHE198
C	GLY202
C	PHE203
G	TRP62
G	THR68
G	PHE69
G	PHE70
G	HIS71
G	ASN76
G	HOH216

site_id	AF5
Number of Residues	11
Details	binding site for residue PEK C 304

Chain	Residue
C	LYS157
C	HIS158
C	GLN161
F	ALA1
G	LYS5
G	ARG17
G	GLY22
G	CDL101
G	CHD102
N	SER279
O	GLN59

site_id	AF6
Number of Residues	21
Details	binding site for residue PGV C 305

Chain	Residue
C	TRP58
C	VAL61
C	ILE62
C	SER65
C	THR66
C	GLU90
C	ILE210
C	PHE214
C	ARG221
C	HIS226
C	PHE227
C	THR228
C	HIS231
C	HIS232
C	PHE233
C	GLY234
C	CDL307
C	HOH412
C	HOH417
C	HOH419
C	HOH491

site_id	AF7
Number of Residues	7
Details	binding site for residue PGV C 306

Chain	Residue
C	TRP99
C	HIS103
C	ALA107
C	CHD301
C	HOH435
C	HOH437
H	ASN22

site_id	AF8
Number of Residues	16
Details	binding site for residue CDL C 307

Chain	Residue
C	MET51
C	TYR55
C	TRP58
C	ARG59
C	ILE62
C	ARG63
C	PHE67
C	THR174
C	THR213
C	LYS224
C	HIS226
C	PGV305
C	HOH490
J	LYS8
J	LEU31
J	EDO102

site_id	AF9
Number of Residues	5
Details	binding site for residue CHD C 308

Chain	Residue
C	ARG156
C	PHE164
C	LEU223
C	HOH514
J	PHE1

site_id	AG1
Number of Residues	7
Details	binding site for residue EDO C 309

Chain	Residue
C	TRP146
C	SER150
C	HIS158
C	HOH411
C	HOH468
F	ALA1
G	ARG17

site_id	AG2
Number of Residues	5
Details	binding site for residue EDO C 310

Chain	Residue
B	HOH422
C	GLU111
C	EDO311
C	HOH479
H	EDO101

site_id	AG3
Number of Residues	6
Details	binding site for residue EDO C 311

Chain	Residue
B	GLY177
C	GLU111
C	EDO310
C	HOH444
H	TRP68
H	EDO101

site_id	AG4
Number of Residues	5
Details	binding site for residue DMU C 312

Chain	Residue
C	ASN38
C	SER39
C	THR41
C	DMU313
J	TYR45

site_id	AG5
Number of Residues	11
Details	binding site for residue DMU C 313

Chain	Residue
A	LEU110
C	SER29
C	MET33
C	PHE37
C	DMU312
C	HOH401
J	SER46
J	TYR48
J	CYS49
J	TRP52
J	ALA53

site_id	AG6
Number of Residues	16
Details	binding site for residue TGL D 201

Chain	Residue
A	TRP334
A	GLY343
A	ALA415
B	LEU46
B	THR47
B	LYS49
D	ARG73
D	THR75
D	GLU77
D	TRP78
D	HOH312
D	HOH400
D	HOH425
D	HOH446
I	ARG16
I	HIS20

site_id	AG7
Number of Residues	4
Details	binding site for residue EDO E 201

Chain	Residue
E	TYR18
E	LYS21
E	GLU28
E	HOH316

site_id	AG8
Number of Residues	4
Details	binding site for residue ZN F 101

Chain	Residue
F	CYS60
F	CYS62
F	CYS82
F	CYS85

site_id	AG9
Number of Residues	8
Details	binding site for residue EDO F 102

Chain	Residue
A	THR490
A	HOH771
F	SER67
F	THR68
F	VAL69
F	TRP71
F	HOH258
F	HOH264

site_id	AH1
Number of Residues	7
Details	binding site for residue EDO F 103

Chain	Residue
C	HIS231
C	HOH492
F	ASP9
F	GLU17
F	MET21
F	HOH203
F	HOH217

site_id	AH2
Number of Residues	19
Details	binding site for residue CDL G 101

Chain	Residue
C	ASN125
C	LEU131
C	TYR253
C	PEK304
G	SER27
G	LEU30
G	CYS31
G	ASN34
G	LEU37
G	HIS38
G	HOH253
N	PHE282
N	ASP300
N	SER307
N	ILE311
O	LEU78
O	LEU81
O	TYR85
P	CHD301

site_id	AH3
Number of Residues	13
Details	binding site for residue CHD G 102

Chain	Residue
C	PEK304
G	ARG14
G	ARG17
G	PHE21
G	GLY22
G	HOH206
G	HOH219
G	HOH245
N	MET271
O	GLU62
O	THR63
O	THR66
O	HOH407

site_id	AH4
Number of Residues	10
Details	binding site for residue PEK G 103

Chain	Residue
G	SER2
G	GLY6
G	HIS8
G	TPO11
P	ARG80
P	TYR81
P	VAL91
P	PHE98
P	TRP240
P	VAL247

site_id	AH5
Number of Residues	7
Details	binding site for residue EDO G 104

Chain	Residue
C	GLY120
G	ALA46
G	PHE47
G	ILE48
G	LEU53
G	ARG54
G	HOH201

site_id	AH6
Number of Residues	6
Details	binding site for residue EDO H 101

Chain	Residue
B	EDO307
C	EDO310
C	EDO311
H	THR71
H	HOH201
H	HOH208

site_id	AH7
Number of Residues	5
Details	binding site for residue CHD J 101

Chain	Residue
A	ILE3
A	LEU7
J	MET36
J	THR37
J	LEU40

site_id	AH8
Number of Residues	7
Details	binding site for residue EDO J 102

Chain	Residue
C	TYR55
C	ARG59
C	CDL307
J	THR27
J	ASP28
J	LEU31
J	HOH221

site_id	AH9
Number of Residues	17
Details	binding site for residue TGL L 101

Chain	Residue
A	PHE2
A	THR17
A	LEU21
A	PHE22
A	TRP25
A	LEU113
A	PHE400
A	ILE472
L	ILE11
L	PRO12
L	SER14
L	ARG20
L	MET24
L	PHE28
L	PHE29
L	SER31
L	HOH201

site_id	AI1
Number of Residues	6
Details	binding site for residue EDO L 102

Chain	Residue
A	TYR502
C	PRO13
L	HIS2
L	TYR3
L	HOH202
L	HOH214

site_id	AI2
Number of Residues	4
Details	binding site for residue EDO L 103

Chain	Residue
L	ASN17
L	LYS18
L	HOH210
L	HOH232

site_id	AI3
Number of Residues	1
Details	binding site for residue EDO L 104

Chain	Residue
L	TRP19

site_id	AI4
Number of Residues	1
Details	binding site for residue EDO L 105

Chain	Residue
L	HOH203

site_id	AI5
Number of Residues	8
Details	binding site for residue DMU M 101

Chain	Residue
D	TRP98
M	LEU27
M	LEU28
M	TRP32
M	TYR35
M	HIS36
M	HOH202
M	HOH211

site_id	AI6
Number of Residues	4
Details	binding site for residue EDO M 102

Chain	Residue
D	VAL103
D	HOH330
M	LYS41
M	HOH210

site_id	AI7
Number of Residues	2
Details	binding site for residue EDO M 103

Chain	Residue
A	THR46
M	LYS41

site_id	AI8
Number of Residues	32
Details	binding site for residue HEA N 601

Chain	Residue
N	GLY27
N	MET28
N	THR31
N	SER34
N	ILE37
N	ARG38
N	TYR54
N	VAL58
N	HIS61
N	ALA62
N	MET65
N	VAL70
N	GLY125
N	TRP126
N	TYR371
N	PHE377
N	HIS378
N	SER382
N	VAL386
N	PHE393
N	MET417
N	PHE425
N	GLN428
N	ARG438
N	ARG439
N	TYR440
N	VAL465
N	MET468
N	EDO613
N	HOH724
N	HOH731
N	HOH762

site_id	AI9
Number of Residues	31
Details	binding site for residue HEA N 602

Chain	Residue
N	TRP126
N	TRP236
N	VAL243
N	TYR244
N	HIS290
N	HIS291
N	THR309
N	ILE312
N	ALA313
N	THR316
N	GLY317
N	GLY352
N	LEU353
N	GLY355
N	ILE356
N	LEU358
N	ALA359
N	ASP364
N	HIS368
N	VAL373
N	HIS376
N	PHE377
N	VAL380
N	LEU381
N	ARG438
N	PER608
N	HOH726
N	HOH741
N	HOH769
N	HOH801
O	ILE34

site_id	AJ1
Number of Residues	4
Details	binding site for residue CU N 603

Chain	Residue
N	HIS240
N	HIS290
N	HIS291
N	PER608

site_id	AJ2
Number of Residues	6
Details	binding site for residue MG N 604

Chain	Residue
N	HIS368
N	ASP369
O	GLU198
O	HOH401
O	HOH456
O	HOH535

site_id	AJ3
Number of Residues	4
Details	binding site for residue NA N 605

Chain	Residue
N	GLU40
N	GLY45
N	SER441
N	HOH875

site_id	AJ4
Number of Residues	15
Details	binding site for residue TGL N 606

Chain	Residue
N	THR17
N	PHE22
N	TRP25
N	LEU113
N	PHE400
N	SER401
N	HOH914
Y	ASN10
Y	ILE11
Y	PRO12
Y	PHE13
Y	MET24
Y	PHE28
Y	PHE29
Y	SER31

site_id	AJ5
Number of Residues	10
Details	binding site for residue PGV N 607

Chain	Residue
N	ASN406
N	ASP407
N	THR408
N	TRP409
N	HOH832
Q	PHE87
X	HIS10
X	HOH114
Z	GLN15
Z	LEU19

site_id	AJ6
Number of Residues	5
Details	binding site for residue PER N 608

Chain	Residue
N	HIS240
N	VAL243
N	HIS291
N	HEA602
N	CU603

site_id	AJ7
Number of Residues	20
Details	binding site for residue PGV N 609

Chain	Residue
N	PHE94
N	PRO95
N	ARG96
N	MET97
N	PHE148
N	HOH704
N	HOH771
P	HIS9
P	GLY20
P	ALA24
P	ASN50
P	TRP57
P	TRP58
P	VAL61
P	GLU64
P	HIS71
P	LEU79
P	GLY82
P	GLU90
P	PEK303

site_id	AJ8
Number of Residues	7
Details	binding site for residue EDO N 610

Chain	Residue
N	HIS256
N	LYS265
N	THR490
N	ASN491
N	HOH750
N	HOH761
N	HOH846

site_id	AJ9
Number of Residues	7
Details	binding site for residue EDO N 611

Chain	Residue
N	TYR260
N	TYR261
N	HIS395
N	TRP494
N	HOH739
N	HOH753
Z	ILE1

site_id	AK1
Number of Residues	2
Details	binding site for residue EDO N 612

Chain	Residue
N	THR489
N	HOH746

site_id	AK2
Number of Residues	7
Details	binding site for residue EDO N 613

Chain	Residue
N	MET390
N	HIS413
N	MET417
N	ALA464
N	VAL465
N	MET468
N	HEA601

site_id	AK3
Number of Residues	7
Details	binding site for residue EDO N 614

Chain	Residue
N	TYR510
N	HOH703
N	HOH880
S	PRO36
S	LYS37
S	THR39
S	LEU48

site_id	AK4
Number of Residues	9
Details	binding site for residue TGL O 301

Chain	Residue
N	PHE346
N	ASN422
N	PHE426
N	LEU433
O	LEU7
O	LEU28
O	PHE32
O	SER35
O	SER36

site_id	AK5
Number of Residues	6
Details	binding site for residue CUA O 302

Chain	Residue
O	HIS161
O	CYS196
O	GLU198
O	CYS200
O	HIS204
O	MET207

site_id	AK6
Number of Residues	13
Details	binding site for residue PSC O 303

Chain	Residue
N	PHE321
N	HIS328
O	ILE41
O	HIS52
O	MET56
O	ASP57
O	TRP65
O	HOH509
R	HIS5
R	GLU6
R	ASP8
R	PHE11
V	ARG10

site_id	AK7
Number of Residues	8
Details	binding site for residue EDO O 304

Chain	Residue
N	TYR447
O	ALA2
O	GLN10
O	LEU136
O	PRO166
O	TYR193
O	HOH435
O	HOH462

site_id	AK8
Number of Residues	12
Details	binding site for residue CHD P 301

Chain	Residue
G	CDL101
N	HIS233
N	ASP300
N	THR301
N	TYR304
N	HOH805
P	TRP99
P	HIS103
P	HOH421
P	HOH469
P	HOH493
U	PGV101

site_id	AK9
Number of Residues	3
Details	binding site for residue NA P 302

Chain	Residue
P	HIS148
P	HIS232
P	GLU236

site_id	AL1
Number of Residues	18
Details	binding site for residue PEK P 303

Chain	Residue
N	HIS151
N	PGV609
N	HOH891
P	TYR181
P	TYR182
P	ALA184
P	PHE186
P	THR187
P	ILE188
P	PHE198
P	GLY202
T	TRP62
T	THR68
T	PHE69
T	PHE70
T	HIS71
T	ASN76
T	HOH222

site_id	AL2
Number of Residues	19
Details	binding site for residue PGV P 304

Chain	Residue
P	MET54
P	TRP58
P	VAL61
P	SER65
P	THR66
P	ILE210
P	PHE214
P	ARG221
P	HIS226
P	PHE227
P	THR228
P	HIS231
P	HIS232
P	PHE233
P	GLY234
P	HOH418
P	HOH426
P	HOH428
P	HOH491

site_id	AL3
Number of Residues	12
Details	binding site for residue CDL P 305

Chain	Residue
P	TYR55
P	TRP58
P	ARG59
P	ILE62
P	ARG63
P	PHE67
P	THR213
P	LYS224
P	HIS226
P	HOH436
P	HOH504
W	LYS8

site_id	AL4
Number of Residues	5
Details	binding site for residue CHD P 306

Chain	Residue
P	ARG156
P	PHE164
P	PHE219
P	LEU223
W	PHE1

site_id	AL5
Number of Residues	3
Details	binding site for residue EDO P 307

Chain	Residue
P	PRO73
P	ARG80
P	HOH482

site_id	AL6
Number of Residues	4
Details	binding site for residue EDO P 309

Chain	Residue
P	HIS3
P	GLN4
P	HOH420
P	HOH423

site_id	AL7
Number of Residues	1
Details	binding site for residue EDO P 310

Chain	Residue
P	THR48

site_id	AL8
Number of Residues	4
Details	binding site for residue EDO P 311

Chain	Residue
P	GLU111
P	EDO312
P	HOH431
P	HOH460

site_id	AL9
Number of Residues	5
Details	binding site for residue EDO P 312

Chain	Residue
O	GLY177
P	GLU111
P	EDO311
P	HOH411
U	TRP68

site_id	AM1
Number of Residues	7
Details	binding site for residue DMU P 313

Chain	Residue
P	PHE37
P	ASN38
P	SER39
P	HOH435
P	HOH452
W	TYR45
W	DMU104

site_id	AM2
Number of Residues	9
Details	binding site for residue TGL Q 201

Chain	Residue
N	GLY343
N	PHE414
N	ALA415
N	HOH713
O	THR47
Q	THR75
Q	GLU77
Q	TRP78
V	ARG16

site_id	AM3
Number of Residues	9
Details	binding site for residue EDO Q 202

Chain	Residue
N	LEU495
N	HOH787
Q	ALA12
Q	LEU13
Q	PRO14
Q	HOH308
Q	HOH354
S	PHE72
S	TRP73

site_id	AM4
Number of Residues	4
Details	binding site for residue EDO R 201

Chain	Residue
R	TYR18
R	LYS21
R	GLU28
R	HOH301

site_id	AM5
Number of Residues	4
Details	binding site for residue EDO R 202

Chain	Residue
R	ARG14
R	TRP15
R	TYR18
R	EDO203

site_id	AM6
Number of Residues	5
Details	binding site for residue EDO R 203

Chain	Residue
R	TRP15
R	TYR18
R	LYS31
R	THR35
R	EDO202

site_id	AM7
Number of Residues	3
Details	binding site for residue EDO R 204

Chain	Residue
R	ARG53
R	ARG57
R	HOH303

site_id	AM8
Number of Residues	4
Details	binding site for residue ZN S 101

Chain	Residue
S	CYS60
S	CYS62
S	CYS82
S	CYS85

site_id	AM9
Number of Residues	8
Details	binding site for residue EDO S 102

Chain	Residue
N	THR490
S	SER67
S	THR68
S	VAL69
S	TRP71
S	HOH229
S	HOH243
S	HOH248

site_id	AN1
Number of Residues	6
Details	binding site for residue EDO S 103

Chain	Residue
P	HOH476
S	ASP9
S	GLU17
S	MET21
S	HOH205
S	HOH232

site_id	AN2
Number of Residues	6
Details	binding site for residue EDO S 104

Chain	Residue
Q	HOH349
Q	HOH355
S	GLN80
S	ARG81
S	PRO83
S	HOH230

site_id	AN3
Number of Residues	12
Details	binding site for residue PEK T 101

Chain	Residue
C	VAL91
C	PHE98
C	TRP240
C	VAL247
T	SER2
T	ALA3
T	LYS5
T	GLY6
T	HIS8
T	TPO11
T	CDL103
T	HOH235

site_id	AN4
Number of Residues	13
Details	binding site for residue PEK T 102

Chain	Residue
A	SER279
B	CHD304
P	HIS158
P	GLN161
P	THR168
P	TYR172
P	HOH406
T	ARG17
T	PHE21
T	GLY22
T	CDL103
T	EDO104
T	HOH249

site_id	AN5
Number of Residues	21
Details	binding site for residue CDL T 103

Chain	Residue
A	PHE282
A	ASP300
A	TYR304
A	SER307
A	ALA308
A	ILE311
B	ALA77
B	TYR85
B	HOH447
C	HOH452
P	ASN125
P	LEU131
P	VAL142
T	SER27
T	CYS31
T	ASN34
T	HIS38
T	PEK101
T	PEK102
T	EDO105
T	HOH250

site_id	AN6
Number of Residues	1
Details	binding site for residue EDO T 104

Chain	Residue
T	PEK102

site_id	AN7
Number of Residues	3
Details	binding site for residue EDO T 105

Chain	Residue
T	LEU30
T	LEU33
T	CDL103

site_id	AN8
Number of Residues	11
Details	binding site for residue PGV U 101

Chain	Residue
G	ALA1
P	THR95
P	TRP99
P	HIS103
P	ALA107
P	CHD301
U	ASN24
U	HOH202
U	HOH206
U	HOH225
U	HOH253

site_id	AN9
Number of Residues	6
Details	binding site for residue CHD W 101

Chain	Residue
N	LEU7
W	TYR32
W	ARG33
W	MET36
W	THR37
W	LEU40

site_id	AO1
Number of Residues	3
Details	binding site for residue EDO W 102

Chain	Residue
S	HOH218
W	LYS10
W	GLN13

site_id	AO2
Number of Residues	6
Details	binding site for residue EDO W 103

Chain	Residue
P	ASN12
P	PRO13
W	GLY17
W	LEU18
W	PRO19
W	HOH201

site_id	AO3
Number of Residues	10
Details	binding site for residue DMU W 104

Chain	Residue
N	LEU110
P	MET33
P	PHE37
P	DMU313
W	TYR45
W	SER46
W	TYR48
W	CYS49
W	TRP52
W	ALA53

site_id	AO4
Number of Residues	3
Details	binding site for residue EDO Y 101

Chain	Residue
Y	HIS2
Y	TYR3
Y	HOH205

site_id	AO5
Number of Residues	7
Details	binding site for residue DMU Z 101

Chain	Residue
N	LEU35
Q	TRP98
Z	LEU27
Z	LEU28
Z	TRP32
Z	TYR35
Z	HIS36

site_id	AO6
Number of Residues	17
Details	binding site for Di-peptide HIS N 240 and TYR N 244

Chain	Residue
N	CU603
N	PER608
N	TRP236
N	PHE238
N	GLY239
N	PRO241
N	GLU242
N	VAL243
N	ILE245
N	LEU246
N	ILE247
N	LEU248
N	ILE280
N	GLY284
N	HIS290
N	ILE312
N	HEA602

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
A	TRP236-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
B	VAL159-MET207

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
F	VAL69-LEU91

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
G	ILE55-ASN72

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	ILE1-SER11
N	SER262-GLY269
N	SER401-ASN406
N	LYS479-LYS514
Z	ILE1-SER11
F	CYS82
F	CYS85
S	CYS60
S	CYS62
S	CYS82
S	CYS85
N	MET171-PRO182

site_id	SWS_FT_FI2
Number of Residues	46
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	PRO12-TYR35
Z	PRO12-TYR35
F	LYS90
S	LYS37
S	LYS55
S	LYS90

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	HIS36-ALA46
Z	HIS36-ALA46
C	ALA184-ASP190
C	TYR257-SER261
P	PHE35-MET40
P	LEU106-GLU128
P	ALA184-ASP190
P	TYR257-SER261

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P17665

Chain	Residue	Details
L	LYS9
Y	LYS9
Q	LYS7
Q	LYS38

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P13073

Chain	Residue	Details
D	LYS31
O	CYS200
O	HIS204
O	MET207
Q	LYS31
B	GLU198
B	CYS200
B	HIS204
B	MET207
O	HIS161
O	CYS196
O	GLU198

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10888

Chain	Residue	Details
D	SER34
D	SER36
Q	SER34
Q	SER36
N	ARG213-ASP227
N	VAL287-ASP298

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P19783

Chain	Residue	Details
D	LYS45
Q	LYS45

site_id	SWS_FT_FI8
Number of Residues	64
Details	TRANSMEM: Helical; Name=VI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
C	GLY191-LEU223
P	GLY191-LEU223

site_id	SWS_FT_FI9
Number of Residues	46
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
C	PHE233-ILE256
P	PHE233-ILE256

site_id	SWS_FT_FI10
Number of Residues	32
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	TYR270-ILE286
N	TYR270-ILE286

site_id	SWS_FT_FI11
Number of Residues	56
Details	TRANSMEM: Helical; Name=VIII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	VAL299-LEU327
N	VAL299-LEU327

site_id	SWS_FT_FI12
Number of Residues	14
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	HIS328-SER335
N	HIS328-SER335

site_id	SWS_FT_FI13
Number of Residues	42
Details	TRANSMEM: Helical; Name=IX => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	PRO336-VAL357
N	PRO336-VAL357

site_id	SWS_FT_FI14
Number of Residues	48
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	LEU358-THR370
A	SER434-ALA446
N	LEU358-THR370
N	SER434-ALA446

site_id	SWS_FT_FI15
Number of Residues	58
Details	TRANSMEM: Helical; Name=X => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	TYR371-PHE400
N	TYR371-PHE400

site_id	SWS_FT_FI16
Number of Residues	52
Details	TRANSMEM: Helical; Name=XI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	ASP407-LEU433
N	ASP407-LEU433

site_id	SWS_FT_FI17
Number of Residues	62
Details	TRANSMEM: Helical; Name=XII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	TYR447-SER478
N	TYR447-SER478

site_id	SWS_FT_FI18
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:27605664, ECO:0000305\|PubMed:23537388

Chain	Residue	Details
A	GLU40
A	GLY45
A	SER441
N	GLU40
N	GLY45
N	SER441

site_id	SWS_FT_FI19
Number of Residues	6
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
A	HIS61
A	HIS376
A	HIS378
N	HIS61
N	HIS376
N	HIS378

site_id	SWS_FT_FI20
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
A	HIS240
N	ASP369
A	HIS290
A	HIS291
A	HIS368
A	ASP369
N	HIS240
N	HIS290
N	HIS291
N	HIS368

site_id	SWS_FT_FI21
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	TYR244
N	TYR244

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:2165784

Chain	Residue	Details
A	FME1
N	FME1

site_id	SWS_FT_FI23
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:10338009

Chain	Residue	Details
A	HIS240
A	TYR244
N	HIS240
N	TYR244

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
A	MET65	metal ligand
A	THR294	metal ligand
A	VAL295	metal ligand, proton acceptor, proton donor
A	VAL320	proton acceptor, proton donor, proton relay
A	TRP323	proton acceptor, proton donor, proton relay
A	ASP442	proton acceptor, proton donor, proton relay
A	PRO95	proton acceptor, proton donor, proton relay
A	PRO130	proton acceptor, proton donor, proton relay
A	GLY160	proton acceptor, proton donor, proton relay
A	ALA161	proton acceptor, proton donor, proton relay
A	TYR244	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
A	LEU246	proton acceptor, proton donor, proton relay
A	LEU248	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
A	THR259	proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
N	MET65	metal ligand
N	THR294	metal ligand
N	VAL295	metal ligand, proton acceptor, proton donor
N	VAL320	proton acceptor, proton donor, proton relay
N	TRP323	proton acceptor, proton donor, proton relay
N	ASP442	proton acceptor, proton donor, proton relay
N	PRO95	proton acceptor, proton donor, proton relay
N	PRO130	proton acceptor, proton donor, proton relay
N	GLY160	proton acceptor, proton donor, proton relay
N	ALA161	proton acceptor, proton donor, proton relay
N	TYR244	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
N	LEU246	proton acceptor, proton donor, proton relay
N	LEU248	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
N	THR259	proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)