5XDF
Homoserine dehydrogenase from Thermus thermophilus HB8 complexed with HSE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004412 | molecular_function | homoserine dehydrogenase activity |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0009086 | biological_process | methionine biosynthetic process |
A | 0009088 | biological_process | threonine biosynthetic process |
A | 0009097 | biological_process | isoleucine biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0050661 | molecular_function | NADP binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004412 | molecular_function | homoserine dehydrogenase activity |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0009086 | biological_process | methionine biosynthetic process |
B | 0009088 | biological_process | threonine biosynthetic process |
B | 0009097 | biological_process | isoleucine biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 12 |
Details | binding site for residue HSE A 1301 |
Chain | Residue |
A | LYS99 |
A | GLY288 |
A | HOH1474 |
A | HOH1555 |
A | ASN150 |
A | GLY151 |
A | THR152 |
A | TYR178 |
A | GLU180 |
A | ASP186 |
A | ASP191 |
A | LYS195 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue NA A 1302 |
Chain | Residue |
A | GLU121 |
A | VAL124 |
A | ALA126 |
A | THR128 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue FMT A 1303 |
Chain | Residue |
A | GLY11 |
A | GLY12 |
A | VAL43 |
A | ARG44 |
A | ASP45 |
A | ARG50 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue HSE B 401 |
Chain | Residue |
B | LYS99 |
B | ASN150 |
B | GLY151 |
B | THR152 |
B | TYR178 |
B | GLU180 |
B | ASP186 |
B | LYS195 |
B | GLY288 |
B | HOH503 |
B | HOH643 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue NA B 402 |
Chain | Residue |
B | GLU121 |
B | VAL124 |
B | ALA126 |
B | THR128 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue FMT B 403 |
Chain | Residue |
B | GLY10 |
B | GLY11 |
B | GLY12 |
B | VAL43 |
B | ARG44 |
B | HOH515 |
B | HOH531 |
Functional Information from PROSITE/UniProt
site_id | PS01042 |
Number of Residues | 23 |
Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
Chain | Residue | Details |
A | ALA173-LYS195 |