5XDF
Homoserine dehydrogenase from Thermus thermophilus HB8 complexed with HSE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue HSE A 1301 |
| Chain | Residue |
| A | LYS99 |
| A | GLY288 |
| A | HOH1474 |
| A | HOH1555 |
| A | ASN150 |
| A | GLY151 |
| A | THR152 |
| A | TYR178 |
| A | GLU180 |
| A | ASP186 |
| A | ASP191 |
| A | LYS195 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 1302 |
| Chain | Residue |
| A | GLU121 |
| A | VAL124 |
| A | ALA126 |
| A | THR128 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 1303 |
| Chain | Residue |
| A | GLY11 |
| A | GLY12 |
| A | VAL43 |
| A | ARG44 |
| A | ASP45 |
| A | ARG50 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue HSE B 401 |
| Chain | Residue |
| B | LYS99 |
| B | ASN150 |
| B | GLY151 |
| B | THR152 |
| B | TYR178 |
| B | GLU180 |
| B | ASP186 |
| B | LYS195 |
| B | GLY288 |
| B | HOH503 |
| B | HOH643 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | GLU121 |
| B | VAL124 |
| B | ALA126 |
| B | THR128 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 403 |
| Chain | Residue |
| B | GLY10 |
| B | GLY11 |
| B | GLY12 |
| B | VAL43 |
| B | ARG44 |
| B | HOH515 |
| B | HOH531 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AqrlGYAea.DPtlDVeGiDaahK |
| Chain | Residue | Details |
| A | ALA173-LYS195 |
