Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5XA8

Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E1-ALF4-ADP-2CA2+ crystals

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005215	molecular_function	transporter activity
A	0005388	molecular_function	P-type calcium transporter activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016887	molecular_function	ATP hydrolysis activity
A	0031448	biological_process	positive regulation of fast-twitch skeletal muscle fiber contraction
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0046872	molecular_function	metal ion binding
A	0070588	biological_process	calcium ion transmembrane transport
A	0106134	biological_process	positive regulation of cardiac muscle cell contraction
A	1901896	biological_process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
A	1902082	biological_process	positive regulation of calcium ion import into sarcoplasmic reticulum
A	1990036	biological_process	calcium ion import into sarcoplasmic reticulum

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CA A 1001

Chain	Residue
A	ASN768
A	GLU771
A	THR799
A	ASP800
A	GLU908
A	HOH1112
A	HOH1139

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 1002

Chain	Residue
A	ILE307
A	GLU309
A	ASN796
A	ASP800
A	VAL304
A	ALA305

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 1003

Chain	Residue
A	ALF1004
A	ADP1006
A	HOH1127
A	HOH1141
A	HOH1211

site_id	AC4
Number of Residues	13
Details	binding site for residue ALF A 1004

Chain	Residue
A	ASP351
A	LYS352
A	THR353
A	THR625
A	GLY626
A	LYS684
A	ASN706
A	MG1003
A	MG1005
A	ADP1006
A	HOH1122
A	HOH1141
A	HOH1211

site_id	AC5
Number of Residues	6
Details	binding site for residue MG A 1005

Chain	Residue
A	ASP351
A	THR353
A	ASP703
A	ALF1004
A	HOH1122
A	HOH1211

site_id	AC6
Number of Residues	21
Details	binding site for residue ADP A 1006

Chain	Residue
A	THR353
A	GLU439
A	GLU442
A	PHE487
A	ARG489
A	MET494
A	LYS515
A	GLY516
A	ARG560
A	LEU562
A	THR625
A	GLY626
A	ASP627
A	ARG678
A	ASN706
A	MG1003
A	ALF1004
A	HOH1111
A	HOH1114
A	HOH1127
A	HOH1141

site_id	AC7
Number of Residues	4
Details	binding site for residue PCW A 1007

Chain	Residue
A	PCW1022
A	PCW1023
A	PCW1025
A	PCW1044

site_id	AC8
Number of Residues	4
Details	binding site for residue PCW A 1008

Chain	Residue
A	ARG63
A	PCW1019
A	PCW1037
A	PCW1050

site_id	AC9
Number of Residues	2
Details	binding site for residue PCW A 1009

Chain	Residue
A	PCW1010
A	PCW1020

site_id	AD1
Number of Residues	4
Details	binding site for residue PCW A 1010

Chain	Residue
A	LYS262
A	LEU266
A	PCW1009
A	PCW1028

site_id	AD2
Number of Residues	1
Details	binding site for residue PCW A 1011

Chain	Residue
A	ILE289

site_id	AD3
Number of Residues	3
Details	binding site for residue PCW A 1012

Chain	Residue
A	GLY831
A	PCW1020
A	PCW1038

site_id	AD4
Number of Residues	3
Details	binding site for residue PCW A 1013

Chain	Residue
A	PCW1014
A	PCW1031
A	PCW1041

site_id	AD5
Number of Residues	5
Details	binding site for residue PCW A 1014

Chain	Residue
A	MET923
A	PHE986
A	ARG989
A	ASN990
A	PCW1013

site_id	AD6
Number of Residues	1
Details	binding site for residue PCW A 1016

Chain	Residue
A	LEU968

site_id	AD7
Number of Residues	7
Details	binding site for residue PCW A 1017

Chain	Residue
A	TRP107
A	GLN108
A	ARG324
A	PHE809
A	TRP932
A	VAL950
A	ASP951

site_id	AD8
Number of Residues	2
Details	binding site for residue PCW A 1018

Chain	Residue
A	LEU49
A	ARG110

site_id	AD9
Number of Residues	1
Details	binding site for residue PCW A 1019

Chain	Residue
A	PCW1008

site_id	AE1
Number of Residues	3
Details	binding site for residue PCW A 1020

Chain	Residue
A	PCW1009
A	PCW1012
A	PCW1048

site_id	AE2
Number of Residues	3
Details	binding site for residue PCW A 1021

Chain	Residue
A	PHE945
A	TYR949
A	ILE931

site_id	AE3
Number of Residues	1
Details	binding site for residue PCW A 1022

Chain	Residue
A	PCW1007

site_id	AE4
Number of Residues	2
Details	binding site for residue PCW A 1023

Chain	Residue
A	PCW1007
A	PCW1046

site_id	AE5
Number of Residues	4
Details	binding site for residue PCW A 1024

Chain	Residue
A	ALA780
A	PCW1032
A	PCW1034
A	PCW1037

site_id	AE6
Number of Residues	1
Details	binding site for residue PCW A 1025

Chain	Residue
A	PCW1007

site_id	AE7
Number of Residues	3
Details	binding site for residue PCW A 1026

Chain	Residue
A	TYR867
A	HIS868
A	PCW1036

site_id	AE8
Number of Residues	1
Details	binding site for residue PCW A 1027

Chain	Residue
A	GLU45

site_id	AE9
Number of Residues	2
Details	binding site for residue PCW A 1028

Chain	Residue
A	PCW1010
A	PCW1049

site_id	AF1
Number of Residues	2
Details	binding site for residue PCW A 1029

Chain	Residue
A	PCW1030
A	PCW1043

site_id	AF2
Number of Residues	4
Details	binding site for residue PCW A 1030

Chain	Residue
A	LYS972
A	PCW1029
A	PCW1042
A	PCW1046

site_id	AF3
Number of Residues	3
Details	binding site for residue PCW A 1031

Chain	Residue
A	PCW1013
A	PCW1051
A	PCW1052

site_id	AF4
Number of Residues	5
Details	binding site for residue PCW A 1032

Chain	Residue
A	HIS278
A	GLY782
A	MET874
A	PCW1024
A	PCW1040

site_id	AF5
Number of Residues	5
Details	binding site for residue PCW A 1034

Chain	Residue
A	LEU781
A	THR871
A	HIS872
A	PCW1024
A	PCW1036

site_id	AF6
Number of Residues	4
Details	binding site for residue PCW A 1035

Chain	Residue
A	LEU273
A	ILE276
A	GLY277
A	ASN280

site_id	AF7
Number of Residues	3
Details	binding site for residue PCW A 1036

Chain	Residue
A	PCW1026
A	PCW1034
A	PCW1049

site_id	AF8
Number of Residues	4
Details	binding site for residue PCW A 1037

Chain	Residue
A	PCW1008
A	PCW1024
A	PCW1040
A	PCW1041

site_id	AF9
Number of Residues	6
Details	binding site for residue PCW A 1038

Chain	Residue
A	SER830
A	GLY831
A	TRP832
A	PHE835
A	PCW1012
A	PCW1039

site_id	AG1
Number of Residues	2
Details	binding site for residue PCW A 1039

Chain	Residue
A	TRP288
A	PCW1038

site_id	AG2
Number of Residues	3
Details	binding site for residue PCW A 1040

Chain	Residue
A	PCW1032
A	PCW1037
A	PCW1045

site_id	AG3
Number of Residues	2
Details	binding site for residue PCW A 1041

Chain	Residue
A	PCW1013
A	PCW1037

site_id	AG4
Number of Residues	1
Details	binding site for residue PCW A 1042

Chain	Residue
A	PCW1030

site_id	AG5
Number of Residues	1
Details	binding site for residue PCW A 1043

Chain	Residue
A	PCW1029

site_id	AG6
Number of Residues	1
Details	binding site for residue PCW A 1044

Chain	Residue
A	PCW1007

site_id	AG7
Number of Residues	2
Details	binding site for residue PCW A 1045

Chain	Residue
A	TYR991
A	PCW1040

site_id	AG8
Number of Residues	4
Details	binding site for residue PCW A 1046

Chain	Residue
A	LEU968
A	LYS972
A	PCW1023
A	PCW1030

site_id	AG9
Number of Residues	1
Details	binding site for residue PCW A 1047

Chain	Residue
A	PHE88

site_id	AH1
Number of Residues	1
Details	binding site for residue PCW A 1048

Chain	Residue
A	PCW1020

site_id	AH2
Number of Residues	2
Details	binding site for residue PCW A 1049

Chain	Residue
A	PCW1028
A	PCW1036

site_id	AH3
Number of Residues	3
Details	binding site for residue PCW A 1050

Chain	Residue
A	ILE54
A	PCW1008
A	PCW1052

site_id	AH4
Number of Residues	2
Details	binding site for residue PCW A 1051

Chain	Residue
A	TRP50
A	PCW1031

site_id	AH5
Number of Residues	2
Details	binding site for residue PCW A 1052

Chain	Residue
A	PCW1031
A	PCW1050

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP351-THR357

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	663
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	108
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	20
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"10551848","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	11
Details	Region: {"description":"Interaction with PLN","evidences":[{"source":"PubMed","id":"23996003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	1
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18075584","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XP5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N5K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5A3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WPG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C8K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UU1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FGO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BEW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZBD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3N8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XA8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10864315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15192230","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15229613","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26175901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1SU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2C9M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BA6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q64578","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 849

Chain	Residue	Details
A	THR355	covalent catalysis
A	ASP707	metal ligand
A	LEU711	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)