5X9Z
Crystal structure of inositol 1,4,5-trisphosphate receptor large cytosolic domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
| B | 0005220 | molecular_function | inositol 1,4,5-trisphosphate-gated calcium channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006816 | biological_process | calcium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0070679 | molecular_function | inositol 1,4,5 trisphosphate binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG265 | |
| A | LYS508 | |
| A | TYR567 | |
| B | ARG265 | |
| B | LYS508 | |
| B | TYR567 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR482 | |
| B | TYR482 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17208939, ECO:0007744|PubMed:18630941, ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER1588 | |
| B | SER1588 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:Q14643, ECO:0000255 |
| Chain | Residue | Details |
| A | SER1755 | |
| B | SER1755 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:25368151 |
| Chain | Residue | Details |
| A | CYS56 | |
| A | CYS849 | |
| B | CYS56 | |
| B | CYS849 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P29994 |
| Chain | Residue | Details |
| A | LYS916 | |
| A | LYS1924 | |
| A | LYS2118 | |
| B | LYS916 | |
| B | LYS962 | |
| B | LYS1571 | |
| B | LYS1771 | |
| B | LYS1884 | |
| B | LYS1885 | |
| B | LYS1886 | |
| B | LYS1901 | |
| B | LYS1924 | |
| B | LYS2118 | |
| A | LYS962 | |
| A | LYS1571 | |
| A | LYS1771 | |
| A | LYS1884 | |
| A | LYS1885 | |
| A | LYS1886 | |
| A | LYS1901 |
