5X86
Crystal structure of TMP bound thymidylate kinase from thermus thermophilus HB8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004798 | molecular_function | thymidylate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006227 | biological_process | dUDP biosynthetic process |
| A | 0006233 | biological_process | dTDP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004798 | molecular_function | thymidylate kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006227 | biological_process | dUDP biosynthetic process |
| B | 0006233 | biological_process | dTDP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL B 201 |
| Chain | Residue |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | LYS16 |
| B | THR17 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | TYR62 |
| B | SER66 |
| B | ARG69 |
| B | ALA115 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 203 |
| Chain | Residue |
| B | ARG157 |
| B | GLY161 |
| B | HOH376 |
| B | HOH429 |
| B | HOH454 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 204 |
| Chain | Residue |
| B | THR7 |
| B | GLU9 |
| B | TYR92 |
| B | ASP94 |
| B | THR127 |
| B | HOH383 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 205 |
| Chain | Residue |
| B | GLU160 |
| B | ARG167 |
| B | HOH439 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 206 |
| Chain | Residue |
| B | ASP12 |
| B | TYR99 |
| B | PHE155 |
| B | HOH312 |
| B | HOH373 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue TMP B 207 |
| Chain | Residue |
| B | ASP12 |
| B | ARG38 |
| B | GLU39 |
| B | PRO40 |
| B | ARG48 |
| B | PHE65 |
| B | ARG69 |
| B | ARG91 |
| B | SER95 |
| B | SER96 |
| B | TYR99 |
| B | GLN100 |
| B | HOH301 |
| B | HOH312 |
| B | HOH362 |
| B | HOH389 |
| B | HOH408 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 201 |
| Chain | Residue |
| A | GLY13 |
| A | GLY15 |
| A | LYS16 |
| A | THR17 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | TYR62 |
| A | SER66 |
| A | ARG69 |
| A | LEU93 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | PRO109 |
| A | HOH420 |
| B | HOH328 |
| B | HOH340 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 204 |
| Chain | Residue |
| A | THR7 |
| A | GLU9 |
| A | TYR92 |
| A | ASP94 |
| A | HOH355 |
| site_id | AD3 |
| Number of Residues | 16 |
| Details | binding site for residue TMP A 205 |
| Chain | Residue |
| A | ASP12 |
| A | ARG38 |
| A | PRO40 |
| A | ARG48 |
| A | PHE65 |
| A | ARG69 |
| A | ARG91 |
| A | SER95 |
| A | SER96 |
| A | TYR99 |
| A | GLN100 |
| A | LEU147 |
| A | LEU150 |
| A | HOH306 |
| A | HOH376 |
| A | HOH422 |
Functional Information from PROSITE/UniProt
| site_id | PS01331 |
| Number of Residues | 13 |
| Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ISDRYldSSlAYQ |
| Chain | Residue | Details |
| B | ILE88-GLN100 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00165 |
| Chain | Residue | Details |
| B | GLY10 | |
| A | GLY10 |
