5X6F

Crystal structure of Phosphopantetheine adenylyltransferase from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
A	0009058	biological_process	biosynthetic process
A	0015937	biological_process	coenzyme A biosynthetic process
A	0016779	molecular_function	nucleotidyltransferase activity
B	0003824	molecular_function	catalytic activity
B	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
B	0009058	biological_process	biosynthetic process
B	0015937	biological_process	coenzyme A biosynthetic process
B	0016779	molecular_function	nucleotidyltransferase activity
C	0003824	molecular_function	catalytic activity
C	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
C	0009058	biological_process	biosynthetic process
C	0015937	biological_process	coenzyme A biosynthetic process
C	0016779	molecular_function	nucleotidyltransferase activity
D	0003824	molecular_function	catalytic activity
D	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
D	0009058	biological_process	biosynthetic process
D	0015937	biological_process	coenzyme A biosynthetic process
D	0016779	molecular_function	nucleotidyltransferase activity
E	0003824	molecular_function	catalytic activity
E	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
E	0009058	biological_process	biosynthetic process
E	0015937	biological_process	coenzyme A biosynthetic process
E	0016779	molecular_function	nucleotidyltransferase activity
F	0003824	molecular_function	catalytic activity
F	0004595	molecular_function	pantetheine-phosphate adenylyltransferase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0008771	molecular_function	[citrate (pro-3S)-lyase] ligase activity
F	0009058	biological_process	biosynthetic process
F	0015937	biological_process	coenzyme A biosynthetic process
F	0016779	molecular_function	nucleotidyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL B 202

Chain	Residue
B	THR9
B	ARG87

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site_id	AC2
Number of Residues	2
Details	binding site for residue GOL D 201

Chain	Residue
D	HIS75
D	GLU79

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL D 202

Chain	Residue
B	GLU133
D	LEU73
D	LEU101
D	ASN105

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL D 203

Chain	Residue
D	ARG87
D	THR9

---

site_id	AC5
Number of Residues	2
Details	binding site for residue IPA F 201

Chain	Residue
F	THR9
F	ARG87

---

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL F 202

Chain	Residue
D	GLU133
D	LEU137
F	LEU73
F	LEU101

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00151

Chain	Residue	Details
A	THR9
B	HIS17
B	LYS41
B	LEU73
B	ARG87
B	GLY88
B	GLU98
B	TYR123
C	THR9
C	HIS17
C	LYS41
A	HIS17
C	LEU73
C	ARG87
C	GLY88
C	GLU98
C	TYR123
D	THR9
D	HIS17
D	LYS41
D	LEU73
D	ARG87
A	LYS41
D	GLY88
D	GLU98
D	TYR123
E	THR9
E	HIS17
E	LYS41
E	LEU73
E	ARG87
E	GLY88
E	GLU98
A	LEU73
E	TYR123
F	THR9
F	HIS17
F	LYS41
F	LEU73
F	ARG87
F	GLY88
F	GLU98
F	TYR123
A	ARG87
A	GLY88
A	GLU98
A	TYR123
B	THR9

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00151

Chain	Residue	Details
A	HIS17
B	HIS17
C	HIS17
D	HIS17
E	HIS17
F	HIS17

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