5X1O

PI(4,5)P2 lipid binding induced a reorientation of FGF2 molecules near membrane surface to facilitate the unconventional oligomerization-dependent secretion process as revealed by a combined FTIR/NMR/X-ray study

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008083	molecular_function	growth factor activity
B	0008083	molecular_function	growth factor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue I3P A 201

Chain	Residue
A	ARG81
A	HOH344
A	LEU82
A	GLN123
A	TYR124
A	I3P202
A	HOH301
A	HOH306
A	HOH325
A	HOH342

---

site_id	AC2
Number of Residues	11
Details	binding site for residue I3P A 202

Chain	Residue
A	LYS77
A	GLU78
A	ARG81
A	LEU83
A	SER85
A	GLU91
A	I3P201
A	HOH302
A	HOH303
A	HOH304
A	HOH358

---

Functional Information from PROSITE/UniProt

site_id	PS00247
Number of Residues	24
Details	HBGF_FGF HBGF/FGF family signature. GrLlAskcvtd.ECfFfErlesnnY

Chain	Residue	Details
A	GLY80-TYR103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Region: {"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Cell attachment site; atypical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Important for interaction with integrin","evidences":[{"source":"PubMed","id":"28302677","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by TEC","evidences":[{"source":"PubMed","id":"20230531","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)","evidences":[{"source":"PubMed","id":"25114211","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---