Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5X1F

CO bound cytochrome c oxidase without pump laser irradiation at 278K

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005751	cellular_component	mitochondrial respiratory chain complex IV
A	0006119	biological_process	oxidative phosphorylation
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0008535	biological_process	respiratory chain complex IV assembly
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	1902600	biological_process	proton transmembrane transport
D	0005751	cellular_component	mitochondrial respiratory chain complex IV
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0005743	cellular_component	mitochondrial inner membrane
E	0005751	cellular_component	mitochondrial respiratory chain complex IV
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0005740	cellular_component	mitochondrial envelope
F	0005751	cellular_component	mitochondrial respiratory chain complex IV
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0005743	cellular_component	mitochondrial inner membrane
G	0005751	cellular_component	mitochondrial respiratory chain complex IV
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0016020	cellular_component	membrane
H	0045277	cellular_component	respiratory chain complex IV
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006119	biological_process	oxidative phosphorylation
I	0016020	cellular_component	membrane
I	0045277	cellular_component	respiratory chain complex IV
J	0005746	cellular_component	mitochondrial respirasome
J	0005751	cellular_component	mitochondrial respiratory chain complex IV
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0005746	cellular_component	mitochondrial respirasome
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0005751	cellular_component	mitochondrial respiratory chain complex IV
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0005751	cellular_component	mitochondrial respiratory chain complex IV
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005751	cellular_component	mitochondrial respiratory chain complex IV
N	0006119	biological_process	oxidative phosphorylation
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0009060	biological_process	aerobic respiration
N	0015990	biological_process	electron transport coupled proton transport
N	0016020	cellular_component	membrane
N	0020037	molecular_function	heme binding
N	0045277	cellular_component	respiratory chain complex IV
N	0046872	molecular_function	metal ion binding
N	0070469	cellular_component	respirasome
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005507	molecular_function	copper ion binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0022900	biological_process	electron transport chain
O	0042773	biological_process	ATP synthesis coupled electron transport
O	0045277	cellular_component	respiratory chain complex IV
O	0046872	molecular_function	metal ion binding
O	0070469	cellular_component	respirasome
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0008535	biological_process	respiratory chain complex IV assembly
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0019646	biological_process	aerobic electron transport chain
P	0022904	biological_process	respiratory electron transport chain
P	0045277	cellular_component	respiratory chain complex IV
P	1902600	biological_process	proton transmembrane transport
Q	0005751	cellular_component	mitochondrial respiratory chain complex IV
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0005743	cellular_component	mitochondrial inner membrane
R	0005751	cellular_component	mitochondrial respiratory chain complex IV
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0005740	cellular_component	mitochondrial envelope
S	0005751	cellular_component	mitochondrial respiratory chain complex IV
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
T	0005743	cellular_component	mitochondrial inner membrane
T	0005751	cellular_component	mitochondrial respiratory chain complex IV
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006119	biological_process	oxidative phosphorylation
U	0016020	cellular_component	membrane
U	0045277	cellular_component	respiratory chain complex IV
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0006119	biological_process	oxidative phosphorylation
V	0016020	cellular_component	membrane
V	0045277	cellular_component	respiratory chain complex IV
W	0005746	cellular_component	mitochondrial respirasome
W	0005751	cellular_component	mitochondrial respiratory chain complex IV
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
X	0005746	cellular_component	mitochondrial respirasome
X	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0005751	cellular_component	mitochondrial respiratory chain complex IV
Y	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Z	0005751	cellular_component	mitochondrial respiratory chain complex IV
Z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	binding site for residue HEA A 601

Chain	Residue
A	MET28
A	MET65
A	ILE66
A	VAL70
A	GLY125
A	TRP126
A	TYR371
A	PHE377
A	HIS378
A	PHE393
A	PHE425
A	THR31
A	GLN428
A	ARG438
A	ARG439
A	VAL465
A	HOH716
A	HOH722
A	HOH779
A	HOH783
A	SER34
A	ILE37
A	ARG38
A	TYR54
A	VAL58
A	HIS61
A	ALA62

site_id	AC2
Number of Residues	28
Details	binding site for residue HEA A 602

Chain	Residue
A	TRP126
A	TRP236
A	VAL243
A	TYR244
A	HIS290
A	HIS291
A	THR309
A	ILE312
A	THR316
A	GLY317
A	GLY352
A	GLY355
A	LEU358
A	ALA359
A	ASP364
A	HIS368
A	VAL373
A	HIS376
A	PHE377
A	VAL380
A	LEU381
A	ARG438
A	CMO606
A	HOH729
A	HOH753
A	HOH761
A	HOH788
B	ILE34

site_id	AC3
Number of Residues	4
Details	binding site for residue CU A 603

Chain	Residue
A	HIS240
A	HIS290
A	HIS291
A	CMO606

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	HIS368
A	ASP369
B	GLU198
B	HOH409
B	HOH435
B	HOH479

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 605

Chain	Residue
A	GLU40
A	GLY45
A	SER441
A	HOH817

site_id	AC6
Number of Residues	6
Details	binding site for residue CMO A 606

Chain	Residue
A	HIS240
A	VAL243
A	HIS290
A	HIS291
A	HEA602
A	CU603

site_id	AC7
Number of Residues	8
Details	binding site for residue TGL A 607

Chain	Residue
A	ASN422
A	HIS429
A	PHE430
A	LEU433
B	GLY8
B	LEU28
B	PHE32
B	SER35

site_id	AC8
Number of Residues	12
Details	binding site for residue PGV A 608

Chain	Residue
A	PHE94
A	PRO95
A	ARG96
A	MET97
A	HOH725
C	HIS9
C	ASN50
C	MET54
C	TRP57
C	TRP58
C	GLU64
C	HIS71

site_id	AC9
Number of Residues	9
Details	binding site for residue PGV A 609

Chain	Residue
A	HOH726
D	PHE87
K	HIS10
M	GLN15
M	LEU19
A	ASN406
A	THR408
A	TRP409
A	ARG480

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO A 610

Chain	Residue
A	TYR260
A	TYR261
A	VAL394
A	HIS395
A	PRO398
A	TRP494
A	HOH701
M	ILE1

site_id	AD2
Number of Residues	1
Details	binding site for residue EDO A 611

Chain	Residue
T	CDL102

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 612

Chain	Residue
A	MET71
A	PRO72
A	SER157
A	HOH709
A	HOH821

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 613

Chain	Residue
A	ASN4
A	ARG5
A	SER9
A	THR10
A	TYR502
A	HOH704
C	PRO13
L	TYR3

site_id	AD5
Number of Residues	7
Details	binding site for residue CUA B 301

Chain	Residue
B	HIS161
B	CYS196
B	GLU198
B	CYS200
B	HIS204
B	MET207
B	HOH465

site_id	AD6
Number of Residues	10
Details	binding site for residue CHD B 302

Chain	Residue
A	MET271
B	GLU62
B	THR63
B	PEK304
B	HOH416
B	HOH470
T	ARG14
T	ARG17
T	PHE21
T	GLY22

site_id	AD7
Number of Residues	5
Details	binding site for residue PSC B 303

Chain	Residue
B	HIS52
B	ASP57
E	ASP8
I	ARG10
I	ARG18

site_id	AD8
Number of Residues	7
Details	binding site for residue PEK B 304

Chain	Residue
B	GLN59
B	CHD302
P	LYS157
P	HIS158
S	ALA1
T	ARG17
T	CDL102

site_id	AD9
Number of Residues	8
Details	binding site for residue EDO B 305

Chain	Residue
A	TYR447
A	HOH763
B	FME1
B	ALA2
B	GLN10
B	PRO166
B	TYR193
B	HOH496

site_id	AE1
Number of Residues	17
Details	binding site for residue PGV C 302

Chain	Residue
C	TRP58
C	VAL61
C	SER65
C	THR66
C	PHE86
C	HIS207
C	ARG221
C	HIS226
C	HIS231
C	PHE233
C	GLY234
C	CDL303
C	HOH402
C	HOH409
C	HOH416
C	HOH440
F	HOH225

site_id	AE2
Number of Residues	16
Details	binding site for residue CDL C 303

Chain	Residue
C	TYR55
C	ARG59
C	ILE62
C	ARG63
C	PHE67
C	THR213
C	PHE220
C	LYS224
C	HIS226
C	PGV302
C	HOH406
C	HOH423
C	HOH455
C	HOH479
J	LYS8
J	THR27

site_id	AE3
Number of Residues	3
Details	binding site for residue CHD C 304

Chain	Residue
C	ARG156
C	HOH434
J	PHE1

site_id	AE4
Number of Residues	11
Details	binding site for residue CHD C 305

Chain	Residue
A	HIS233
A	ASP300
A	THR301
A	TYR304
A	HOH744
C	TRP99
C	HIS103
C	PGV307
C	EDO312
C	HOH456
T	CDL102

site_id	AE5
Number of Residues	8
Details	binding site for residue PEK C 306

Chain	Residue
C	LYS157
C	HIS158
C	HOH410
F	ALA1
G	ARG17
G	PHE21
G	CDL102
G	CHD104

site_id	AE6
Number of Residues	12
Details	binding site for residue PGV C 307

Chain	Residue
C	TRP99
C	TYR102
C	HIS103
C	ALA107
C	CHD305
C	EDO311
C	EDO312
C	HOH403
H	ASN22
H	ASN24
P	TRP258
T	SER2

site_id	AE7
Number of Residues	7
Details	binding site for residue PEK C 308

Chain	Residue
C	ARG80
C	TRP240
C	VAL247
C	EDO311
T	SER2
T	ALA3
T	HIS8

site_id	AE8
Number of Residues	4
Details	binding site for residue EDO C 309

Chain	Residue
C	THR145
C	HIS149
C	HOH468
G	TRP16

site_id	AE9
Number of Residues	2
Details	binding site for residue EDO C 310

Chain	Residue
C	THR145
G	CDL102

site_id	AF1
Number of Residues	2
Details	binding site for residue EDO C 311

Chain	Residue
C	PGV307
C	PEK308

site_id	AF2
Number of Residues	5
Details	binding site for residue EDO C 312

Chain	Residue
C	HIS103
C	ALA107
C	CHD305
C	PGV307
C	HOH401

site_id	AF3
Number of Residues	9
Details	binding site for residue TGL D 201

Chain	Residue
A	TRP334
A	ALA415
B	THR47
D	SER74
D	THR75
D	GLU77
D	TRP78
D	HOH357
I	ARG16

site_id	AF4
Number of Residues	4
Details	binding site for residue ZN F 101

Chain	Residue
F	CYS60
F	CYS62
F	CYS82
F	CYS85

site_id	AF5
Number of Residues	5
Details	binding site for residue EDO F 102

Chain	Residue
A	TYR510
F	LYS37
F	THR39
F	ASN47
F	LEU48

site_id	AF6
Number of Residues	17
Details	binding site for residue PEK G 101

Chain	Residue
A	VAL155
A	ALA203
C	TYR181
C	TYR182
C	ALA184
C	THR187
C	ILE188
C	PHE198
C	GLY202
C	GLY205
G	TRP62
G	THR68
G	PHE69
G	PHE70
G	HIS71
G	ASN76
G	HOH213

site_id	AF7
Number of Residues	18
Details	binding site for residue CDL G 102

Chain	Residue
C	ASN125
C	LEU127
C	PEK306
C	EDO310
G	LEU30
G	CYS31
G	ASN34
G	HIS38
G	HOH229
N	PHE282
N	ASP300
N	TYR304
N	SER307
N	EDO610
O	ILE74
O	ALA77
O	LEU78
O	LEU81

site_id	AF8
Number of Residues	5
Details	binding site for residue PEK G 103

Chain	Residue
G	SER2
G	ALA3
P	LEU85
P	TRP240
P	PHE244

site_id	AF9
Number of Residues	11
Details	binding site for residue CHD G 104

Chain	Residue
C	PEK306
G	ARG14
G	ARG17
G	GLY22
G	HOH215
N	MET271
N	GLY272
N	TRP275
O	GLN59
O	GLU62
O	THR63

site_id	AG1
Number of Residues	6
Details	binding site for residue EDO G 105

Chain	Residue
C	GLY120
G	ALA46
G	PHE47
G	ILE48
G	LEU53
G	ARG54

site_id	AG2
Number of Residues	6
Details	binding site for residue EDO I 101

Chain	Residue
E	VAL42
E	GLU44
I	MET9
I	ARG10
I	HOH206
I	HOH208

site_id	AG3
Number of Residues	4
Details	binding site for residue CHD J 101

Chain	Residue
J	TYR32
J	ARG33
J	THR37
J	LEU40

site_id	AG4
Number of Residues	1
Details	binding site for residue EDO K 101

Chain	Residue
K	TRP29

site_id	AG5
Number of Residues	2
Details	binding site for residue EDO K 103

Chain	Residue
K	TRP40
K	HOH215

site_id	AG6
Number of Residues	11
Details	binding site for residue TGL L 101

Chain	Residue
A	PHE2
A	THR17
A	LEU21
A	TRP25
A	PHE400
L	ILE11
L	PRO12
L	PHE13
L	ARG20
L	PHE28
L	HOH212

site_id	AG7
Number of Residues	3
Details	binding site for residue EDO L 103

Chain	Residue
L	HIS42
L	HOH203
L	HOH215

site_id	AG8
Number of Residues	6
Details	binding site for residue DMU M 101

Chain	Residue
D	TRP98
M	LEU27
M	LEU28
M	TRP32
M	TYR35
M	HIS36

site_id	AG9
Number of Residues	26
Details	binding site for residue HEA N 601

Chain	Residue
N	THR31
N	SER34
N	ILE37
N	ARG38
N	TYR54
N	VAL58
N	HIS61
N	ALA62
N	MET65
N	ILE66
N	VAL70
N	GLY125
N	TRP126
N	TYR371
N	PHE377
N	HIS378
N	SER382
N	PHE425
N	GLN428
N	ARG438
N	ARG439
N	HOH707
N	HOH732
N	HOH733
N	HOH744
N	HOH791

site_id	AH1
Number of Residues	27
Details	binding site for residue HEA N 602

Chain	Residue
N	TRP126
N	TRP236
N	VAL243
N	TYR244
N	HIS290
N	HIS291
N	ILE312
N	THR316
N	GLY317
N	GLY352
N	GLY355
N	ILE356
N	LEU358
N	ALA359
N	ASP364
N	HIS368
N	VAL373
N	HIS376
N	PHE377
N	VAL380
N	ARG438
N	CMO606
N	HOH743
N	HOH759
N	HOH770
N	HOH809
O	PRO69

site_id	AH2
Number of Residues	4
Details	binding site for residue CU N 603

Chain	Residue
N	HIS240
N	HIS290
N	HIS291
N	CMO606

site_id	AH3
Number of Residues	6
Details	binding site for residue MG N 604

Chain	Residue
N	HIS368
N	ASP369
O	GLU198
O	HOH405
O	HOH448
O	HOH456

site_id	AH4
Number of Residues	4
Details	binding site for residue NA N 605

Chain	Residue
N	GLU40
N	GLY45
N	SER441
N	HOH803

site_id	AH5
Number of Residues	5
Details	binding site for residue CMO N 606

Chain	Residue
N	HIS240
N	VAL243
N	HIS291
N	HEA602
N	CU603

site_id	AH6
Number of Residues	12
Details	binding site for residue PGV N 607

Chain	Residue
N	PHE94
N	PRO95
N	ARG96
N	MET97
N	HOH756
P	HIS9
P	ASN50
P	MET54
P	TRP57
P	TRP58
P	GLU64
P	HIS71

site_id	AH7
Number of Residues	8
Details	binding site for residue PGV N 608

Chain	Residue
N	ASP298
N	HOH702
P	TRP99
P	TYR102
P	HIS103
P	CHD305
U	ASN22
U	HOH102

site_id	AH8
Number of Residues	6
Details	binding site for residue TGL N 609

Chain	Residue
N	PHE426
N	LEU433
O	GLY8
O	LEU28
O	LEU39
V	ARG43

site_id	AH9
Number of Residues	1
Details	binding site for residue EDO N 610

Chain	Residue
G	CDL102

site_id	AI1
Number of Residues	1
Details	binding site for residue EDO N 611

Chain	Residue
N	MET117

site_id	AI2
Number of Residues	3
Details	binding site for residue EDO N 612

Chain	Residue
N	TYR261
N	HIS395
N	HOH711

site_id	AI3
Number of Residues	8
Details	binding site for residue CUA O 301

Chain	Residue
O	HIS161
O	CYS196
O	GLU198
O	CYS200
O	HIS204
O	MET207
O	HOH417
O	HOH480

site_id	AI4
Number of Residues	11
Details	binding site for residue PSC O 302

Chain	Residue
O	HIS52
O	MET56
O	ASP57
O	GLU60
O	TRP65
R	GLU6
R	ASP8
R	PHE11
R	HOH226
R	HOH234
V	ARG10

site_id	AI5
Number of Residues	19
Details	binding site for residue PGV P 302

Chain	Residue
P	VAL61
P	SER65
P	THR66
P	PHE86
P	HIS207
P	ILE210
P	PHE214
P	ARG221
P	HIS226
P	PHE227
P	HIS231
P	HIS232
P	PHE233
P	GLY234
P	CDL303
P	HOH401
P	HOH444
S	HOH207
S	HOH212

site_id	AI6
Number of Residues	8
Details	binding site for residue CDL P 303

Chain	Residue
P	MET51
P	TYR55
P	ARG63
P	LYS224
P	HIS226
P	PGV302
P	HOH451
W	LYS8

site_id	AI7
Number of Residues	6
Details	binding site for residue CHD P 304

Chain	Residue
P	ARG156
P	LEU160
P	PHE164
P	PHE219
P	LEU223
W	PHE1

site_id	AI8
Number of Residues	7
Details	binding site for residue CHD P 305

Chain	Residue
N	HIS233
N	THR301
N	TYR304
N	PGV608
P	TRP99
P	HIS103
P	HOH422

site_id	AI9
Number of Residues	1
Details	binding site for residue EDO P 306

Chain	Residue
P	THR145

site_id	AJ1
Number of Residues	2
Details	binding site for residue EDO P 307

Chain	Residue
P	TRP258
P	HOH457

site_id	AJ2
Number of Residues	8
Details	binding site for residue TGL Q 201

Chain	Residue
N	TRP334
N	HOH701
Q	ARG73
Q	THR75
Q	GLU77
Q	TRP78
Q	HOH327
V	ARG16

site_id	AJ3
Number of Residues	4
Details	binding site for residue ZN S 101

Chain	Residue
S	CYS60
S	CYS62
S	CYS82
S	CYS85

site_id	AJ4
Number of Residues	4
Details	binding site for residue EDO S 102

Chain	Residue
N	TYR510
S	LYS37
S	THR39
S	LEU48

site_id	AJ5
Number of Residues	15
Details	binding site for residue PEK T 101

Chain	Residue
N	ALA203
P	TYR181
P	TYR182
P	ALA184
P	PHE186
P	THR187
P	ILE188
P	PHE198
P	GLY202
T	THR68
T	PHE69
T	PHE70
T	HIS71
T	ASN76
T	HOH209

site_id	AJ6
Number of Residues	15
Details	binding site for residue CDL T 102

Chain	Residue
A	PHE282
A	ASP300
A	SER307
A	ILE311
A	EDO611
B	ALA77
B	TYR85
B	PEK304
C	CHD305
P	LEU127
T	ALA1
T	SER27
T	CYS31
T	ASN34
T	HIS38

site_id	AJ7
Number of Residues	2
Details	binding site for residue EDO T 103

Chain	Residue
A	MET278
T	LYS5

site_id	AJ8
Number of Residues	4
Details	binding site for residue CHD W 101

Chain	Residue
W	TYR32
W	ARG33
W	MET36
W	THR37

site_id	AJ9
Number of Residues	12
Details	binding site for residue TGL Y 101

Chain	Residue
N	PHE2
N	THR17
N	LEU21
N	PHE400
Y	ILE11
Y	PRO12
Y	PHE13
Y	SER14
Y	ARG20
Y	MET24
Y	MET25
Y	HOH207

site_id	AK1
Number of Residues	9
Details	binding site for residue PGV Z 101

Chain	Residue
N	ASN406
N	TRP409
Q	ALA84
X	PHE9
Z	ALA3
Z	LYS4
Z	GLN15
Z	ALA16
Z	HOH203

site_id	AK2
Number of Residues	5
Details	binding site for residue DMU Z 102

Chain	Residue
Q	TRP98
Z	LEU27
Z	LEU28
Z	TRP32
Z	TYR35

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
A	TRP236-HIS291

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
G	ILE55-ASN72

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
F	VAL69-LEU91

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
B	VAL159-MET207

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	ILE1-SER11
Z	ILE1-SER11
N	SER262-GLY269
N	SER401-ASN406
N	LYS479-LYS514
N	MET171-PRO182
F	CYS82
F	CYS85
S	CYS60
S	CYS62
S	CYS82
S	CYS85

site_id	SWS_FT_FI2
Number of Residues	46
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	PRO12-TYR35
Z	PRO12-TYR35
F	LYS90
S	LYS37
S	LYS55
S	LYS90

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
M	HIS36-ALA46
Z	HIS36-ALA46
C	ALA184-ASP190
C	TYR257-SER261
P	PHE35-MET40
P	LEU106-GLU128
P	ALA184-ASP190
P	TYR257-SER261

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P17665

Chain	Residue	Details
L	LYS9
Y	LYS9
Q	LYS7
Q	LYS38

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P13073

Chain	Residue	Details
B	HIS204
B	MET207
O	HIS161
O	CYS196
O	GLU198
O	CYS200
O	HIS204
O	MET207
D	LYS31
Q	LYS31
B	GLU198
B	CYS200

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P10888

Chain	Residue	Details
D	SER34
D	SER36
Q	SER34
Q	SER36
N	ARG213-ASP227
N	VAL287-ASP298

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P19783

Chain	Residue	Details
Q	LYS45
D	LYS45

site_id	SWS_FT_FI8
Number of Residues	64
Details	TRANSMEM: Helical; Name=VI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
C	GLY191-LEU223
P	GLY191-LEU223

site_id	SWS_FT_FI9
Number of Residues	46
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
C	PHE233-ILE256
P	PHE233-ILE256

site_id	SWS_FT_FI10
Number of Residues	32
Details	TRANSMEM: Helical; Name=VII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
N	TYR270-ILE286
A	TYR270-ILE286

site_id	SWS_FT_FI11
Number of Residues	56
Details	TRANSMEM: Helical; Name=VIII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
N	VAL299-LEU327
A	VAL299-LEU327

site_id	SWS_FT_FI12
Number of Residues	14
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
N	HIS328-SER335
A	HIS328-SER335

site_id	SWS_FT_FI13
Number of Residues	42
Details	TRANSMEM: Helical; Name=IX => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
N	PRO336-VAL357
A	PRO336-VAL357

site_id	SWS_FT_FI14
Number of Residues	48
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	SER434-ALA446
N	LEU358-THR370
N	SER434-ALA446
A	LEU358-THR370

site_id	SWS_FT_FI15
Number of Residues	58
Details	TRANSMEM: Helical; Name=X => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	TYR371-PHE400
N	TYR371-PHE400

site_id	SWS_FT_FI16
Number of Residues	52
Details	TRANSMEM: Helical; Name=XI => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	ASP407-LEU433
N	ASP407-LEU433

site_id	SWS_FT_FI17
Number of Residues	62
Details	TRANSMEM: Helical; Name=XII => ECO:0000269\|PubMed:27605664

Chain	Residue	Details
A	TYR447-SER478
N	TYR447-SER478

site_id	SWS_FT_FI18
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:27605664, ECO:0000305\|PubMed:23537388

Chain	Residue	Details
A	SER441
N	GLU40
N	GLY45
N	SER441
A	GLU40
A	GLY45

site_id	SWS_FT_FI19
Number of Residues	6
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
N	HIS376
N	HIS378
A	HIS61
A	HIS376
A	HIS378
N	HIS61

site_id	SWS_FT_FI20
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269\|PubMed:20385840, ECO:0000269\|PubMed:8638158

Chain	Residue	Details
A	ASP369
N	HIS240
N	HIS290
N	HIS291
N	HIS368
N	ASP369
A	HIS240
A	HIS290
A	HIS291
A	HIS368

site_id	SWS_FT_FI21
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	TYR244
N	TYR244

site_id	SWS_FT_FI22
Number of Residues	2
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:2165784

Chain	Residue	Details
A	FME1
N	FME1

site_id	SWS_FT_FI23
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:10338009

Chain	Residue	Details
N	HIS240
N	TYR244
A	HIS240
A	TYR244

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
A	HIS61	metal ligand
A	ASP91	proton acceptor, proton donor, proton relay
A	TRP126	proton acceptor, proton donor, proton relay
A	SER156	proton acceptor, proton donor, proton relay
A	SER157	proton acceptor, proton donor, proton relay
A	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
A	GLU242	proton acceptor, proton donor, proton relay
A	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
A	SER255	proton acceptor, proton donor, proton relay
A	HIS290	metal ligand
A	HIS291	metal ligand, proton acceptor, proton donor
A	THR316	proton acceptor, proton donor, proton relay
A	LYS319	proton acceptor, proton donor, proton relay
A	ARG438	proton acceptor, proton donor, proton relay

site_id	MCSA2
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
N	HIS61	metal ligand
N	ASP91	proton acceptor, proton donor, proton relay
N	TRP126	proton acceptor, proton donor, proton relay
N	SER156	proton acceptor, proton donor, proton relay
N	SER157	proton acceptor, proton donor, proton relay
N	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
N	GLU242	proton acceptor, proton donor, proton relay
N	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
N	SER255	proton acceptor, proton donor, proton relay
N	HIS290	metal ligand
N	HIS291	metal ligand, proton acceptor, proton donor
N	THR316	proton acceptor, proton donor, proton relay
N	LYS319	proton acceptor, proton donor, proton relay
N	ARG438	proton acceptor, proton donor, proton relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)