5X16
Sirt6 apo structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | binding site for residue AR6 A 401 |
| Chain | Residue |
| A | GLY50 |
| A | HIS131 |
| A | TRP186 |
| A | GLY212 |
| A | THR213 |
| A | SER214 |
| A | ILE217 |
| A | ASN238 |
| A | LEU239 |
| A | GLN240 |
| A | GLY254 |
| A | ALA51 |
| A | TYR255 |
| A | VAL256 |
| A | TBU404 |
| A | HOH534 |
| A | HOH540 |
| A | HOH541 |
| A | HOH603 |
| A | HOH621 |
| A | HOH655 |
| A | HOH684 |
| A | GLY52 |
| A | THR55 |
| A | ASP61 |
| A | PHE62 |
| A | ARG63 |
| A | TRP69 |
| A | GLN111 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | CYS139 |
| A | CYS142 |
| A | CYS164 |
| A | CYS175 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue TBU A 403 |
| Chain | Residue |
| A | THR55 |
| A | ALA56 |
| A | ASN204 |
| A | ARG230 |
| A | HOH512 |
| A | HOH630 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue TBU A 404 |
| Chain | Residue |
| A | HIS131 |
| A | TRP186 |
| A | ILE217 |
| A | AR6401 |
| A | HOH622 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLU281 |
| A | ARG282 |
| A | HOH643 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:18337721, ECO:0000305|PubMed:23552949, ECO:0000305|PubMed:23892288, ECO:0000305|PubMed:27322069, ECO:0000305|PubMed:28406396 |
| Chain | Residue | Details |
| A | HIS131 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
| Chain | Residue | Details |
| A | ALA51 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23552949, ECO:0000305|PubMed:21362626, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3ZG6 |
| Chain | Residue | Details |
| A | THR55 | |
| A | GLN240 | |
| A | VAL256 | |
| A | PHE62 | |
| A | ARG63 | |
| A | TRP69 | |
| A | GLN111 | |
| A | HIS131 | |
| A | GLY212 | |
| A | SER214 | |
| A | ASN238 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:21362626, ECO:0000269|PubMed:23552949, ECO:0000269|PubMed:27990725, ECO:0007744|PDB:3K35, ECO:0007744|PDB:3PKI, ECO:0007744|PDB:3PKJ, ECO:0007744|PDB:3ZG6, ECO:0007744|PDB:5MF6, ECO:0007744|PDB:5MFP, ECO:0007744|PDB:5MFZ, ECO:0007744|PDB:5MGN |
| Chain | Residue | Details |
| A | CYS139 | |
| A | CYS142 | |
| A | CYS164 | |
| A | CYS175 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Formation of an covalent adduct with nitro-fatty acid activators => ECO:0000269|PubMed:33122195 |
| Chain | Residue | Details |
| A | CYS16 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:27568560, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:32538779 |
| Chain | Residue | Details |
| A | LYS31 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | THR292 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER301 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24043303 |
| Chain | Residue | Details |
| A | LYS168 |
