5WZY
Crystal structure of the P2X4 receptor from zebrafish in the presence of CTP at 2.8 Angstroms
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| A | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0033198 | biological_process | response to ATP |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvMGVqIrWdCDLDmpqswCvPrYtF |
| Chain | Residue | Details |
| A | GLY253-PHE279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical => ECO:0000305|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | PHE37-TYR57 | |
| A | ALA344-MET364 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 285 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | GLN58-GLY343 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28332633, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | LYS70 | |
| A | LYS72 | |
| A | ARG143 | |
| A | THR189 | |
| A | ASN296 | |
| A | ARG298 | |
| A | LYS316 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22535247, ECO:0007744|PDB:4DW1 |
| Chain | Residue | Details |
| A | LEU191 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0000312|PDB:3I5D |
| Chain | Residue | Details |
| A | LYS78 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0000269|PubMed:22535247, ECO:0007744|PDB:3H9V, ECO:0007744|PDB:3I5D, ECO:0007744|PDB:4DW0, ECO:0007744|PDB:4DW1, ECO:0007744|PDB:5WZY |
| Chain | Residue | Details |
| A | ASN113 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0007744|PDB:3I5D |
| Chain | Residue | Details |
| A | ARG187 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19641588, ECO:0007744|PDB:3I5D, ECO:0007744|PDB:4DW0, ECO:0007744|PDB:4DW1 |
| Chain | Residue | Details |
| A | ASN213 |
