5WY9
Apo form crystal structure of human Lipocalin PGDS .
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001516 | biological_process | prostaglandin biosynthetic process |
| A | 0004667 | molecular_function | prostaglandin-D synthase activity |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005791 | cellular_component | rough endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006693 | biological_process | prostaglandin metabolic process |
| A | 0010467 | biological_process | gene expression |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019371 | biological_process | cyclooxygenase pathway |
| A | 0031965 | cellular_component | nuclear membrane |
| A | 0036094 | molecular_function | small molecule binding |
| A | 0043303 | biological_process | mast cell degranulation |
| A | 0045187 | biological_process | regulation of circadian sleep/wake cycle, sleep |
| A | 0046457 | biological_process | prostanoid biosynthetic process |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051384 | biological_process | response to glucocorticoid |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 2000255 | biological_process | negative regulation of male germ cell proliferation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue PG0 A 201 |
| Chain | Residue |
| A | ASP37 |
| A | LEU55 |
| A | LYS58 |
| A | LYS59 |
| A | LEU62 |
| A | HOH368 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PG0 A 202 |
| Chain | Residue |
| A | HOH316 |
| A | THR91 |
| A | ARG92 |
| A | THR93 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue 1PG A 203 |
| Chain | Residue |
| A | MET94 |
| A | TYR116 |
| A | SER133 |
| A | GLY140 |
| A | MET145 |
| A | TYR149 |
| A | HOH303 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA |
| Chain | Residue | Details |
| A | ASN33-ALA46 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"20667974","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"23234360","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8336134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8336134","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
