5WXH
Crystal structure of TAF3 PHD finger bound to H3K4me3
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | CYS885 |
| A | CYS888 |
| A | CYS911 |
| A | CYS914 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | CYS870 |
| A | CYS873 |
| A | HIS893 |
| A | CYS896 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1001 |
| Chain | Residue |
| C | CYS888 |
| C | CYS911 |
| C | CYS914 |
| C | CYS885 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1002 |
| Chain | Residue |
| C | CYS870 |
| C | CYS873 |
| C | HIS893 |
| C | CYS896 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for Ligand residues M3L D 4 through GLN D 5 bound to THR D 3 |
| Chain | Residue |
| A | TRP863 |
| C | TRP868 |
| C | ASP877 |
| C | GLY879 |
| C | PRO881 |
| C | MET882 |
| C | TRP891 |
| D | THR3 |
| D | THR6 |
| D | ALA7 |
| D | HOH107 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for Ligand residues M3L P 4 through GLN P 5 bound to THR P 3 |
| Chain | Residue |
| A | ASP877 |
| A | GLY879 |
| A | PRO881 |
| A | MET882 |
| A | TRP891 |
| C | TRP863 |
| C | ASP886 |
| C | GLN908 |
| C | PHE910 |
| C | HOH1148 |
| P | THR3 |
| P | THR6 |
| P | ALA7 |
| P | HOH101 |
| P | HOH107 |
Functional Information from PROSITE/UniProt
| site_id | PS01359 |
| Number of Residues | 45 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. CpgCnkpddgspm....................................IgCdd..Cddw.YHwpCvgimtappeemq.................................WfCpkC |
| Chain | Residue | Details |
| A | CYS870-CYS914 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Zinc finger: {"description":"PHD-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00146","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5C13","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Citrulline; alternate","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by HASPIN and VRK1","evidences":[{"source":"PubMed","id":"15681610","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16185088","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
