5WRJ
Crystal structure of human tyrosylprotein sulfotransferase-1 complexed with PAP and gastrin peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| A | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| B | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| B | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| C | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| C | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
| D | 0006478 | biological_process | peptidyl-tyrosine sulfation |
| D | 0008476 | molecular_function | protein-tyrosine sulfotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue A3P A 401 |
| Chain | Residue |
| A | ARG79 |
| A | TYR239 |
| A | HIS268 |
| A | SER286 |
| A | GLN289 |
| A | VAL290 |
| A | LYS292 |
| A | PRO293 |
| A | VAL294 |
| A | ASN295 |
| A | ALA298 |
| A | SER80 |
| A | LYS301 |
| A | HOH509 |
| A | GLY81 |
| A | THR82 |
| A | THR83 |
| A | LEU84 |
| A | ARG184 |
| A | SER192 |
| A | ARG196 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP90 |
| A | HIS92 |
| A | ILE95 |
| A | GLY276 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue A3P B 401 |
| Chain | Residue |
| B | ARG79 |
| B | SER80 |
| B | GLY81 |
| B | THR82 |
| B | THR83 |
| B | LEU84 |
| B | ARG184 |
| B | SER192 |
| B | ARG196 |
| B | TYR239 |
| B | SER286 |
| B | GLN289 |
| B | VAL290 |
| B | LYS292 |
| B | PRO293 |
| B | VAL294 |
| B | ASN295 |
| B | ALA298 |
| B | LYS301 |
| B | HOH511 |
| B | HOH524 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP90 |
| B | HIS92 |
| B | ILE95 |
| B | GLY276 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue A3P C 401 |
| Chain | Residue |
| C | ARG79 |
| C | SER80 |
| C | GLY81 |
| C | THR82 |
| C | THR83 |
| C | LEU84 |
| C | ARG184 |
| C | SER192 |
| C | ARG196 |
| C | TYR239 |
| C | HIS268 |
| C | SER286 |
| C | GLN289 |
| C | VAL290 |
| C | LYS292 |
| C | PRO293 |
| C | VAL294 |
| C | ASN295 |
| C | ALA298 |
| C | LYS301 |
| C | HOH505 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 402 |
| Chain | Residue |
| C | ASP90 |
| C | HIS92 |
| C | PRO93 |
| C | ILE95 |
| C | GLY276 |
| C | HOH512 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue A3P D 401 |
| Chain | Residue |
| D | HOH525 |
| D | ARG79 |
| D | SER80 |
| D | GLY81 |
| D | THR82 |
| D | THR83 |
| D | LEU84 |
| D | ARG184 |
| D | SER192 |
| D | ARG196 |
| D | TYR239 |
| D | HIS268 |
| D | SER286 |
| D | GLN289 |
| D | VAL290 |
| D | LYS292 |
| D | PRO293 |
| D | VAL294 |
| D | ASN295 |
| D | ALA298 |
| D | LYS301 |
| D | HOH508 |
| D | HOH523 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 402 |
| Chain | Residue |
| D | ASP90 |
| D | HIS92 |
| D | ILE95 |
| D | GLY276 |
Functional Information from PROSITE/UniProt
| site_id | PS00259 |
| Number of Residues | 6 |
| Details | GASTRIN Gastrin / cholecystokinin family signature. Y.GWMDF |
| Chain | Residue | Details |
| F | TYR1006-PHE1011 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Region: {"description":"Interaction with peptide substrate","evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"O60704","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5WRI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WRJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5WRI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"O60704","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16859706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Sulfotyrosine; partial","evidences":[{"source":"PubMed","id":"11052986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7530658","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
