5WRI
Crystal structure of human tyrosylprotein sulfotransferase-1 complexed with PAP and C4 peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue A3P A 401 |
| Chain | Residue |
| A | ARG79 |
| A | SER286 |
| A | GLN289 |
| A | VAL290 |
| A | LYS292 |
| A | PRO293 |
| A | ASN295 |
| A | LYS301 |
| A | HOH516 |
| A | HOH524 |
| A | HOH561 |
| A | SER80 |
| A | GLY81 |
| A | THR82 |
| A | THR83 |
| A | ARG184 |
| A | SER192 |
| A | ARG196 |
| A | TYR239 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | ASP90 |
| A | HIS92 |
| A | ILE95 |
| A | GLY276 |
| A | HOH527 |
| A | HOH577 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | SER115 |
| A | SER118 |
| A | LYS121 |
| A | MET227 |
| A | GLY230 |
| A | TYR231 |
| A | HOH502 |
| A | HOH589 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue A3P B 401 |
| Chain | Residue |
| B | ARG79 |
| B | SER80 |
| B | GLY81 |
| B | THR82 |
| B | THR83 |
| B | ARG184 |
| B | SER192 |
| B | ARG196 |
| B | TYR239 |
| B | SER286 |
| B | GLN289 |
| B | VAL290 |
| B | LYS292 |
| B | PRO293 |
| B | VAL294 |
| B | ASN295 |
| B | ALA298 |
| B | LYS301 |
| B | HOH518 |
| B | HOH521 |
| B | HOH563 |
| B | HOH643 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 402 |
| Chain | Residue |
| B | ASP90 |
| B | HIS92 |
| B | ILE95 |
| B | GLY276 |
| B | HOH533 |
| B | HOH639 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 403 |
| Chain | Residue |
| A | HIS263 |
| A | HIS267 |
| B | HIS267 |
| B | GLU269 |
| B | GLU270 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with peptide substrate","evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"O60704","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5WRI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WRJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28821720","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5WRI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"O60704","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16859706","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
