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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5WPT

Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0001891cellular_componentphagocytic cup
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0005253molecular_functionmonoatomic anion channel activity
A0005261molecular_functionmonoatomic cation channel activity
A0005262molecular_functioncalcium channel activity
A0005267molecular_functionpotassium channel activity
A0005272molecular_functionsodium channel activity
A0005381molecular_functioniron ion transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005770cellular_componentlate endosome
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007040biological_processlysosome organization
A0008289molecular_functionlipid binding
A0008324molecular_functionmonoatomic cation transmembrane transporter activity
A0016020cellular_componentmembrane
A0016197biological_processendosomal transport
A0019722biological_processcalcium-mediated signaling
A0030659cellular_componentcytoplasmic vesicle membrane
A0030670cellular_componentphagocytic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031902cellular_componentlate endosome membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0034755biological_processiron ion transmembrane transport
A0035725biological_processsodium ion transmembrane transport
A0042802molecular_functionidentical protein binding
A0043235cellular_componentreceptor complex
A0045824biological_processnegative regulation of innate immune response
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0070588biological_processcalcium ion transmembrane transport
A0071277biological_processcellular response to calcium ion
A0071467biological_processcellular response to pH
A0071805biological_processpotassium ion transmembrane transport
A0072345molecular_functionNAADP-sensitive calcium-release channel activity
A0090382biological_processphagosome maturation
A0097352biological_processautophagosome maturation
A0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
A0097708cellular_componentintracellular vesicle
A0098655biological_processmonoatomic cation transmembrane transport
A0098656biological_processmonoatomic anion transmembrane transport
A0099604molecular_functionligand-gated calcium channel activity
A0140367biological_processantibacterial innate immune response
A1900181biological_processnegative regulation of protein localization to nucleus
A1900182biological_processpositive regulation of protein localization to nucleus
A1901660biological_processcalcium ion export
A1905673biological_processpositive regulation of lysosome organization
B0001891cellular_componentphagocytic cup
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0005253molecular_functionmonoatomic anion channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005262molecular_functioncalcium channel activity
B0005267molecular_functionpotassium channel activity
B0005272molecular_functionsodium channel activity
B0005381molecular_functioniron ion transmembrane transporter activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005770cellular_componentlate endosome
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007040biological_processlysosome organization
B0008289molecular_functionlipid binding
B0008324molecular_functionmonoatomic cation transmembrane transporter activity
B0016020cellular_componentmembrane
B0016197biological_processendosomal transport
B0019722biological_processcalcium-mediated signaling
B0030659cellular_componentcytoplasmic vesicle membrane
B0030670cellular_componentphagocytic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0031902cellular_componentlate endosome membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0034755biological_processiron ion transmembrane transport
B0035725biological_processsodium ion transmembrane transport
B0042802molecular_functionidentical protein binding
B0043235cellular_componentreceptor complex
B0045824biological_processnegative regulation of innate immune response
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0070588biological_processcalcium ion transmembrane transport
B0071277biological_processcellular response to calcium ion
B0071467biological_processcellular response to pH
B0071805biological_processpotassium ion transmembrane transport
B0072345molecular_functionNAADP-sensitive calcium-release channel activity
B0090382biological_processphagosome maturation
B0097352biological_processautophagosome maturation
B0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
B0097708cellular_componentintracellular vesicle
B0098655biological_processmonoatomic cation transmembrane transport
B0098656biological_processmonoatomic anion transmembrane transport
B0099604molecular_functionligand-gated calcium channel activity
B0140367biological_processantibacterial innate immune response
B1900181biological_processnegative regulation of protein localization to nucleus
B1900182biological_processpositive regulation of protein localization to nucleus
B1901660biological_processcalcium ion export
B1905673biological_processpositive regulation of lysosome organization
C0001891cellular_componentphagocytic cup
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0005253molecular_functionmonoatomic anion channel activity
C0005261molecular_functionmonoatomic cation channel activity
C0005262molecular_functioncalcium channel activity
C0005267molecular_functionpotassium channel activity
C0005272molecular_functionsodium channel activity
C0005381molecular_functioniron ion transmembrane transporter activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005770cellular_componentlate endosome
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007040biological_processlysosome organization
C0008289molecular_functionlipid binding
C0008324molecular_functionmonoatomic cation transmembrane transporter activity
C0016020cellular_componentmembrane
C0016197biological_processendosomal transport
C0019722biological_processcalcium-mediated signaling
C0030659cellular_componentcytoplasmic vesicle membrane
C0030670cellular_componentphagocytic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0031902cellular_componentlate endosome membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0034755biological_processiron ion transmembrane transport
C0035725biological_processsodium ion transmembrane transport
C0042802molecular_functionidentical protein binding
C0043235cellular_componentreceptor complex
C0045824biological_processnegative regulation of innate immune response
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0070588biological_processcalcium ion transmembrane transport
C0071277biological_processcellular response to calcium ion
C0071467biological_processcellular response to pH
C0071805biological_processpotassium ion transmembrane transport
C0072345molecular_functionNAADP-sensitive calcium-release channel activity
C0090382biological_processphagosome maturation
C0097352biological_processautophagosome maturation
C0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
C0097708cellular_componentintracellular vesicle
C0098655biological_processmonoatomic cation transmembrane transport
C0098656biological_processmonoatomic anion transmembrane transport
C0099604molecular_functionligand-gated calcium channel activity
C0140367biological_processantibacterial innate immune response
C1900181biological_processnegative regulation of protein localization to nucleus
C1900182biological_processpositive regulation of protein localization to nucleus
C1901660biological_processcalcium ion export
C1905673biological_processpositive regulation of lysosome organization
D0001891cellular_componentphagocytic cup
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0005253molecular_functionmonoatomic anion channel activity
D0005261molecular_functionmonoatomic cation channel activity
D0005262molecular_functioncalcium channel activity
D0005267molecular_functionpotassium channel activity
D0005272molecular_functionsodium channel activity
D0005381molecular_functioniron ion transmembrane transporter activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005770cellular_componentlate endosome
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007040biological_processlysosome organization
D0008289molecular_functionlipid binding
D0008324molecular_functionmonoatomic cation transmembrane transporter activity
D0016020cellular_componentmembrane
D0016197biological_processendosomal transport
D0019722biological_processcalcium-mediated signaling
D0030659cellular_componentcytoplasmic vesicle membrane
D0030670cellular_componentphagocytic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0031902cellular_componentlate endosome membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0034755biological_processiron ion transmembrane transport
D0035725biological_processsodium ion transmembrane transport
D0042802molecular_functionidentical protein binding
D0043235cellular_componentreceptor complex
D0045824biological_processnegative regulation of innate immune response
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0070588biological_processcalcium ion transmembrane transport
D0071277biological_processcellular response to calcium ion
D0071467biological_processcellular response to pH
D0071805biological_processpotassium ion transmembrane transport
D0072345molecular_functionNAADP-sensitive calcium-release channel activity
D0090382biological_processphagosome maturation
D0097352biological_processautophagosome maturation
D0097682molecular_functionintracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity
D0097708cellular_componentintracellular vesicle
D0098655biological_processmonoatomic cation transmembrane transport
D0098656biological_processmonoatomic anion transmembrane transport
D0099604molecular_functionligand-gated calcium channel activity
D0140367biological_processantibacterial innate immune response
D1900181biological_processnegative regulation of protein localization to nucleus
D1900182biological_processpositive regulation of protein localization to nucleus
D1901660biological_processcalcium ion export
D1905673biological_processpositive regulation of lysosome organization
Functional Information from PROSITE/UniProt
site_idPS00120
Number of Residues10
DetailsLIPASE_SER Lipases, serine active site. LFLLGYSDGS
ChainResidueDetails
ALEU104-SER113
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues196
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues120
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues88
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues80
DetailsRegion: {"description":"Interaction with phosphoinositides","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues56
DetailsRegion: {"description":"Extracellular/lumenal pore loop","evidences":[{"source":"UniProtKB","id":"Q9GZU1","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues20
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28936784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29019981","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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