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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5WP6

Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0002407biological_processdendritic cell chemotaxis
A0002724biological_processregulation of T cell cytokine production
A0005216molecular_functionmonoatomic ion channel activity
A0005227molecular_functioncalcium-activated cation channel activity
A0005262molecular_functioncalcium channel activity
A0005272molecular_functionsodium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008284biological_processpositive regulation of cell population proliferation
A0010460biological_processpositive regulation of heart rate
A0016020cellular_componentmembrane
A0016925biological_processprotein sumoylation
A0019722biological_processcalcium-mediated signaling
A0030001biological_processmetal ion transport
A0030502biological_processnegative regulation of bone mineralization
A0034220biological_processmonoatomic ion transmembrane transport
A0034706cellular_componentsodium channel complex
A0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
A0043025cellular_componentneuronal cell body
A0045600biological_processpositive regulation of fat cell differentiation
A0045668biological_processnegative regulation of osteoblast differentiation
A0045907biological_processpositive regulation of vasoconstriction
A0046872molecular_functionmetal ion binding
A0046873molecular_functionmetal ion transmembrane transporter activity
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0071318biological_processcellular response to ATP
A0086045biological_processmembrane depolarization during AV node cell action potential
A0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
A0086048biological_processmembrane depolarization during bundle of His cell action potential
A0086091biological_processregulation of heart rate by cardiac conduction
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0098655biological_processmonoatomic cation transmembrane transport
A0098662biological_processinorganic cation transmembrane transport
A0098719biological_processsodium ion import across plasma membrane
A0098911biological_processregulation of ventricular cardiac muscle cell action potential
A1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
A1904179biological_processpositive regulation of adipose tissue development
A1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
B0000166molecular_functionnucleotide binding
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0002407biological_processdendritic cell chemotaxis
B0002724biological_processregulation of T cell cytokine production
B0005216molecular_functionmonoatomic ion channel activity
B0005227molecular_functioncalcium-activated cation channel activity
B0005262molecular_functioncalcium channel activity
B0005272molecular_functionsodium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008284biological_processpositive regulation of cell population proliferation
B0010460biological_processpositive regulation of heart rate
B0016020cellular_componentmembrane
B0016925biological_processprotein sumoylation
B0019722biological_processcalcium-mediated signaling
B0030001biological_processmetal ion transport
B0030502biological_processnegative regulation of bone mineralization
B0034220biological_processmonoatomic ion transmembrane transport
B0034706cellular_componentsodium channel complex
B0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
B0043025cellular_componentneuronal cell body
B0045600biological_processpositive regulation of fat cell differentiation
B0045668biological_processnegative regulation of osteoblast differentiation
B0045907biological_processpositive regulation of vasoconstriction
B0046872molecular_functionmetal ion binding
B0046873molecular_functionmetal ion transmembrane transporter activity
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0071318biological_processcellular response to ATP
B0086045biological_processmembrane depolarization during AV node cell action potential
B0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
B0086048biological_processmembrane depolarization during bundle of His cell action potential
B0086091biological_processregulation of heart rate by cardiac conduction
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0098655biological_processmonoatomic cation transmembrane transport
B0098662biological_processinorganic cation transmembrane transport
B0098719biological_processsodium ion import across plasma membrane
B0098911biological_processregulation of ventricular cardiac muscle cell action potential
B1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
B1904179biological_processpositive regulation of adipose tissue development
B1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
C0000166molecular_functionnucleotide binding
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0002407biological_processdendritic cell chemotaxis
C0002724biological_processregulation of T cell cytokine production
C0005216molecular_functionmonoatomic ion channel activity
C0005227molecular_functioncalcium-activated cation channel activity
C0005262molecular_functioncalcium channel activity
C0005272molecular_functionsodium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005783cellular_componentendoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008284biological_processpositive regulation of cell population proliferation
C0010460biological_processpositive regulation of heart rate
C0016020cellular_componentmembrane
C0016925biological_processprotein sumoylation
C0019722biological_processcalcium-mediated signaling
C0030001biological_processmetal ion transport
C0030502biological_processnegative regulation of bone mineralization
C0034220biological_processmonoatomic ion transmembrane transport
C0034706cellular_componentsodium channel complex
C0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
C0043025cellular_componentneuronal cell body
C0045600biological_processpositive regulation of fat cell differentiation
C0045668biological_processnegative regulation of osteoblast differentiation
C0045907biological_processpositive regulation of vasoconstriction
C0046872molecular_functionmetal ion binding
C0046873molecular_functionmetal ion transmembrane transporter activity
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0071318biological_processcellular response to ATP
C0086045biological_processmembrane depolarization during AV node cell action potential
C0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
C0086048biological_processmembrane depolarization during bundle of His cell action potential
C0086091biological_processregulation of heart rate by cardiac conduction
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0098655biological_processmonoatomic cation transmembrane transport
C0098662biological_processinorganic cation transmembrane transport
C0098719biological_processsodium ion import across plasma membrane
C0098911biological_processregulation of ventricular cardiac muscle cell action potential
C1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
C1904179biological_processpositive regulation of adipose tissue development
C1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
D0000166molecular_functionnucleotide binding
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0002407biological_processdendritic cell chemotaxis
D0002724biological_processregulation of T cell cytokine production
D0005216molecular_functionmonoatomic ion channel activity
D0005227molecular_functioncalcium-activated cation channel activity
D0005262molecular_functioncalcium channel activity
D0005272molecular_functionsodium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005654cellular_componentnucleoplasm
D0005783cellular_componentendoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008284biological_processpositive regulation of cell population proliferation
D0010460biological_processpositive regulation of heart rate
D0016020cellular_componentmembrane
D0016925biological_processprotein sumoylation
D0019722biological_processcalcium-mediated signaling
D0030001biological_processmetal ion transport
D0030502biological_processnegative regulation of bone mineralization
D0034220biological_processmonoatomic ion transmembrane transport
D0034706cellular_componentsodium channel complex
D0035774biological_processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
D0043025cellular_componentneuronal cell body
D0045600biological_processpositive regulation of fat cell differentiation
D0045668biological_processnegative regulation of osteoblast differentiation
D0045907biological_processpositive regulation of vasoconstriction
D0046872molecular_functionmetal ion binding
D0046873molecular_functionmetal ion transmembrane transporter activity
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0071318biological_processcellular response to ATP
D0086045biological_processmembrane depolarization during AV node cell action potential
D0086047biological_processmembrane depolarization during Purkinje myocyte cell action potential
D0086048biological_processmembrane depolarization during bundle of His cell action potential
D0086091biological_processregulation of heart rate by cardiac conduction
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0098655biological_processmonoatomic cation transmembrane transport
D0098662biological_processinorganic cation transmembrane transport
D0098719biological_processsodium ion import across plasma membrane
D0098911biological_processregulation of ventricular cardiac muscle cell action potential
D1903949biological_processpositive regulation of atrial cardiac muscle cell action potential
D1904179biological_processpositive regulation of adipose tissue development
D1904199biological_processpositive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue DVT A 2001
ChainResidue
AARG1138
AARG1141
AARG1147
ALYS1154
DLYS1149
site_idAC2
Number of Residues4
Detailsbinding site for residue DVT A 2002
ChainResidue
AARG421
APHE423
DTHR160
DARG214
site_idAC3
Number of Residues5
Detailsbinding site for residue DVT B 2001
ChainResidue
ALYS1149
BARG1138
BARG1141
BARG1147
BLYS1154
site_idAC4
Number of Residues4
Detailsbinding site for residue DVT B 2002
ChainResidue
ATHR160
AARG214
BARG421
BPHE423
site_idAC5
Number of Residues5
Detailsbinding site for residue DVT C 2001
ChainResidue
BLYS1149
CARG1138
CARG1141
CARG1147
CLYS1154
site_idAC6
Number of Residues4
Detailsbinding site for residue DVT C 2002
ChainResidue
BTHR160
BARG214
CARG421
CPHE423
site_idAC7
Number of Residues5
Detailsbinding site for residue DVT D 2001
ChainResidue
CLYS1149
DARG1138
DARG1141
DARG1147
DLYS1154
site_idAC8
Number of Residues4
Detailsbinding site for residue DVT D 2002
ChainResidue
CTHR160
CARG214
DARG421
DPHE423
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues492
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues224
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues80
DetailsIntramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsRegion: {"description":"Mediates modulation by decavanadate and PIP2-binding","evidences":[{"source":"PubMed","id":"16424899","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues212
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsMotif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"29211723","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q7TN37","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B91","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B90","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B8Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B91","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9B8W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B8Y","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues8
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"Q7TN37","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38750366","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6BQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B92","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"15590641","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"29217581","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

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PDB entries from 2025-10-08

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