5WMF

Crystal structure of the Hexameric Ring of Epstein-Barr Virus Nuclear Antigen-1, EBNA1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006275	biological_process	regulation of DNA replication
A	0006355	biological_process	regulation of DNA-templated transcription
A	0042025	cellular_component	host cell nucleus
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006275	biological_process	regulation of DNA replication
B	0006355	biological_process	regulation of DNA-templated transcription
B	0042025	cellular_component	host cell nucleus
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006275	biological_process	regulation of DNA replication
C	0006355	biological_process	regulation of DNA-templated transcription
C	0042025	cellular_component	host cell nucleus
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006275	biological_process	regulation of DNA replication
D	0006355	biological_process	regulation of DNA-templated transcription
D	0042025	cellular_component	host cell nucleus
D	0045893	biological_process	positive regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0006275	biological_process	regulation of DNA replication
E	0006355	biological_process	regulation of DNA-templated transcription
E	0042025	cellular_component	host cell nucleus
E	0045893	biological_process	positive regulation of DNA-templated transcription
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0006275	biological_process	regulation of DNA replication
F	0006355	biological_process	regulation of DNA-templated transcription
F	0042025	cellular_component	host cell nucleus
F	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: For site-specific DNA endonuclease activity => ECO:0000269|PubMed:33482082

Chain	Residue	Details
A	TYR518
B	TYR518
C	TYR518
D	TYR518
E	TYR518
F	TYR518

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: covalent => ECO:0000269|PubMed:33482082

Chain	Residue	Details
A	TYR518
B	TYR518
C	TYR518
D	TYR518
E	TYR518
F	TYR518

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site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Interaction dimer-dimer => ECO:0000269|PubMed:31142669

Chain	Residue	Details
A	ARG491
B	ARG491
C	ARG491
D	ARG491
E	ARG491
F	ARG491

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site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Interaction dimer-dimer. Required for episome maintenance and generation of immortalized B cells in the host => ECO:0000269|PubMed:31142669, ECO:0000269|PubMed:33482082

Chain	Residue	Details
A	TYR518
B	TYR518
C	TYR518
D	TYR518
E	TYR518
F	TYR518

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