Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5WI4

CRYSTAL STRUCTURE OF DYNLT1/TCTEX-1 IN COMPLEX WITH ARHGEF2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000132	biological_process	establishment of mitotic spindle orientation
A	0001917	cellular_component	photoreceptor inner segment
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005819	cellular_component	spindle
A	0005868	cellular_component	cytoplasmic dynein complex
A	0007018	biological_process	microtubule-based movement
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0010659	biological_process	cardiac muscle cell apoptotic process
A	0010976	biological_process	positive regulation of neuron projection development
A	0016358	biological_process	dendrite development
A	0019060	biological_process	intracellular transport of viral protein in host cell
A	0030027	cellular_component	lamellipodium
A	0030286	cellular_component	dynein complex
A	0030426	cellular_component	growth cone
A	0030742	molecular_function	GTP-dependent protein binding
A	0031681	molecular_function	G-protein beta-subunit binding
A	0035022	biological_process	positive regulation of Rac protein signal transduction
A	0035795	biological_process	negative regulation of mitochondrial membrane permeability
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043657	cellular_component	host cell
A	0044295	cellular_component	axonal growth cone
A	0044297	cellular_component	cell body
A	0044325	molecular_function	transmembrane transporter binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0048812	biological_process	neuron projection morphogenesis
A	0050768	biological_process	negative regulation of neurogenesis
A	0051493	biological_process	regulation of cytoskeleton organization
A	0061564	biological_process	axon development
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0000132	biological_process	establishment of mitotic spindle orientation
B	0001917	cellular_component	photoreceptor inner segment
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005819	cellular_component	spindle
B	0005868	cellular_component	cytoplasmic dynein complex
B	0007018	biological_process	microtubule-based movement
B	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
B	0010659	biological_process	cardiac muscle cell apoptotic process
B	0010976	biological_process	positive regulation of neuron projection development
B	0016358	biological_process	dendrite development
B	0019060	biological_process	intracellular transport of viral protein in host cell
B	0030027	cellular_component	lamellipodium
B	0030286	cellular_component	dynein complex
B	0030426	cellular_component	growth cone
B	0030742	molecular_function	GTP-dependent protein binding
B	0031681	molecular_function	G-protein beta-subunit binding
B	0035022	biological_process	positive regulation of Rac protein signal transduction
B	0035795	biological_process	negative regulation of mitochondrial membrane permeability
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043657	cellular_component	host cell
B	0044295	cellular_component	axonal growth cone
B	0044297	cellular_component	cell body
B	0044325	molecular_function	transmembrane transporter binding
B	0045505	molecular_function	dynein intermediate chain binding
B	0048812	biological_process	neuron projection morphogenesis
B	0050768	biological_process	negative regulation of neurogenesis
B	0051493	biological_process	regulation of cytoskeleton organization
B	0061564	biological_process	axon development
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0000132	biological_process	establishment of mitotic spindle orientation
C	0001917	cellular_component	photoreceptor inner segment
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005819	cellular_component	spindle
C	0005868	cellular_component	cytoplasmic dynein complex
C	0007018	biological_process	microtubule-based movement
C	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
C	0010659	biological_process	cardiac muscle cell apoptotic process
C	0010976	biological_process	positive regulation of neuron projection development
C	0016358	biological_process	dendrite development
C	0019060	biological_process	intracellular transport of viral protein in host cell
C	0030027	cellular_component	lamellipodium
C	0030286	cellular_component	dynein complex
C	0030426	cellular_component	growth cone
C	0030742	molecular_function	GTP-dependent protein binding
C	0031681	molecular_function	G-protein beta-subunit binding
C	0035022	biological_process	positive regulation of Rac protein signal transduction
C	0035795	biological_process	negative regulation of mitochondrial membrane permeability
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043657	cellular_component	host cell
C	0044295	cellular_component	axonal growth cone
C	0044297	cellular_component	cell body
C	0044325	molecular_function	transmembrane transporter binding
C	0045505	molecular_function	dynein intermediate chain binding
C	0048812	biological_process	neuron projection morphogenesis
C	0050768	biological_process	negative regulation of neurogenesis
C	0051493	biological_process	regulation of cytoskeleton organization
C	0061564	biological_process	axon development
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue SO4 A 201

Chain	Residue
A	ASN32
A	LYS38
A	TRP42
A	SER121
A	HOH329
A	HOH335

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
B	HIS78
B	ALA135
A	TYR34
A	HIS36
A	GLN71

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLY76
A	HIS78
A	ALA135
B	TYR34
B	HIS36
B	GLN71

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 B 201

Chain	Residue
B	ASN32
B	LYS38
B	TRP42
C	SER121

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q92974","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by PAK4","evidences":[{"source":"UniProtKB","id":"Q92974","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)