5WHA
KRas G12V, bound to GDP and miniprotein 225-11
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005525 | molecular_function | GTP binding |
| D | 0007165 | biological_process | signal transduction |
| D | 0016020 | cellular_component | membrane |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005525 | molecular_function | GTP binding |
| G | 0007165 | biological_process | signal transduction |
| G | 0016020 | cellular_component | membrane |
| J | 0003924 | molecular_function | GTPase activity |
| J | 0005525 | molecular_function | GTP binding |
| J | 0007165 | biological_process | signal transduction |
| J | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | SER17 |
| A | GDP202 |
| A | HOH310 |
| A | HOH313 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue GDP A 202 |
| Chain | Residue |
| A | SER17 |
| A | ALA18 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG201 |
| A | HOH310 |
| A | HOH314 |
| A | VAL12 |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| A | GLU63 |
| A | TYR64 |
| F | ASP16 |
| F | GLU19 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 204 |
| Chain | Residue |
| A | GLU63 |
| B | ALA32 |
| F | ASP16 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 201 |
| Chain | Residue |
| D | SER17 |
| D | GDP202 |
| D | HOH305 |
| D | HOH329 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue GDP D 202 |
| Chain | Residue |
| D | VAL12 |
| D | GLY13 |
| D | VAL14 |
| D | GLY15 |
| D | LYS16 |
| D | SER17 |
| D | ALA18 |
| D | PHE28 |
| D | ASN116 |
| D | LYS117 |
| D | ASP119 |
| D | LEU120 |
| D | SER145 |
| D | ALA146 |
| D | LYS147 |
| D | MG201 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 203 |
| Chain | Residue |
| C | ASP16 |
| D | GLU63 |
| E | ALA32 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 204 |
| Chain | Residue |
| C | ASP16 |
| C | GLU19 |
| D | GLU63 |
| D | TYR64 |
| D | HOH319 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue MG G 201 |
| Chain | Residue |
| G | SER17 |
| G | GDP202 |
| G | HOH303 |
| G | HOH312 |
| G | HOH317 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue GDP G 202 |
| Chain | Residue |
| G | VAL12 |
| G | GLY13 |
| G | GLY15 |
| G | LYS16 |
| G | SER17 |
| G | ALA18 |
| G | PHE28 |
| G | ASN116 |
| G | LYS117 |
| G | ASP119 |
| G | LEU120 |
| G | SER145 |
| G | ALA146 |
| G | LYS147 |
| G | MG201 |
| G | HOH303 |
| G | HOH312 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CA G 203 |
| Chain | Residue |
| G | GLU63 |
| H | ALA32 |
| L | ASP16 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue CA G 204 |
| Chain | Residue |
| G | GLU63 |
| G | TYR64 |
| H | HOH105 |
| L | ASP16 |
| L | GLU19 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue CA I 101 |
| Chain | Residue |
| I | ASP16 |
| I | HOH202 |
| J | GLU63 |
| K | ALA32 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue CA I 102 |
| Chain | Residue |
| I | ASP16 |
| I | GLU19 |
| J | GLU63 |
| J | TYR64 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue MG J 201 |
| Chain | Residue |
| J | SER17 |
| J | GDP202 |
| J | HOH310 |
| J | HOH316 |
| site_id | AD7 |
| Number of Residues | 17 |
| Details | binding site for residue GDP J 202 |
| Chain | Residue |
| J | GLY13 |
| J | VAL14 |
| J | GLY15 |
| J | LYS16 |
| J | SER17 |
| J | ALA18 |
| J | ASN116 |
| J | LYS117 |
| J | ASP119 |
| J | LEU120 |
| J | SER145 |
| J | ALA146 |
| J | LYS147 |
| J | MG201 |
| J | HOH310 |
| J | HOH316 |
| J | VAL12 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22431598","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22566140","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34380736","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase KRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"22711838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase KRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
