5WH1
Apo form of the C-terminal region of human Transcription Factor IIB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006352 | biological_process | DNA-templated transcription initiation |
| A | 0017025 | molecular_function | TBP-class protein binding |
| A | 0070897 | biological_process | transcription preinitiation complex assembly |
| B | 0006352 | biological_process | DNA-templated transcription initiation |
| B | 0017025 | molecular_function | TBP-class protein binding |
| B | 0070897 | biological_process | transcription preinitiation complex assembly |
| C | 0006352 | biological_process | DNA-templated transcription initiation |
| C | 0017025 | molecular_function | TBP-class protein binding |
| C | 0070897 | biological_process | transcription preinitiation complex assembly |
| D | 0006352 | biological_process | DNA-templated transcription initiation |
| D | 0017025 | molecular_function | TBP-class protein binding |
| D | 0070897 | biological_process | transcription preinitiation complex assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | ASP282 |
| A | VAL283 |
| A | ARG286 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG286 |
| A | ARG290 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | TYR259 |
| A | GLN263 |
| A | THR270 |
| A | GLN271 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | HIS234 |
| A | ARG237 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | HIS234 |
| A | PHE300 |
| A | PRO301 |
| A | THR302 |
| C | MET107 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | VAL283 |
| B | ARG286 |
| B | ARG290 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | TYR259 |
| B | GLN263 |
| B | THR270 |
| B | GLN271 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 403 |
| Chain | Residue |
| B | HIS234 |
| B | ARG237 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| B | HIS234 |
| B | LYS238 |
| B | PRO301 |
| B | THR302 |
| D | MET107 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ASP282 |
| B | ARG286 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 401 |
| Chain | Residue |
| C | TYR259 |
| C | GLN263 |
| C | THR270 |
| C | GLN271 |
| C | LYS272 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 402 |
| Chain | Residue |
| C | VAL283 |
| C | ARG286 |
| C | ARG290 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 403 |
| Chain | Residue |
| C | ASP282 |
| C | VAL283 |
| C | ARG286 |
| C | SO4408 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 404 |
| Chain | Residue |
| C | TYR165 |
| C | THR176 |
| C | PHE177 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 405 |
| Chain | Residue |
| C | SER187 |
| C | LYS188 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 406 |
| Chain | Residue |
| C | HIS234 |
| C | ARG237 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 407 |
| Chain | Residue |
| C | HIS234 |
| C | LYS238 |
| C | PRO301 |
| C | THR302 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 408 |
| Chain | Residue |
| C | ALA281 |
| C | ASP282 |
| C | SO4403 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 401 |
| Chain | Residue |
| D | TYR259 |
| D | GLN263 |
| D | THR270 |
| D | GLN271 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 402 |
| Chain | Residue |
| D | VAL283 |
| D | ARG286 |
| D | ARG290 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 403 |
| Chain | Residue |
| D | HIS234 |
| D | ARG237 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 404 |
| Chain | Residue |
| D | ALA281 |
| D | ASP282 |
| D | SO4405 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 405 |
| Chain | Residue |
| D | ASP282 |
| D | VAL283 |
| D | ARG286 |
| D | SO4404 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 406 |
| Chain | Residue |
| D | TYR165 |
| D | ARG169 |
| D | THR176 |
| D | PHE177 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 D 407 |
| Chain | Residue |
| D | SER187 |
| D | LYS188 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 408 |
| Chain | Residue |
| D | HIS234 |
| D | LYS238 |
| D | PRO301 |
| D | THR302 |
Functional Information from PROSITE/UniProt
| site_id | PS00782 |
| Number of Residues | 16 |
| Details | TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC |
| Chain | Residue | Details |
| A | GLY153-CYS168 | |
| A | GLY247-SER262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27193682, ECO:0007744|PDB:5IYD |
| Chain | Residue | Details |
| A | ARG248 | |
| A | LYS272 | |
| A | ALA281 | |
| A | THR284 | |
| A | ARG286 | |
| A | ARG290 | |
| B | LYS152 | |
| B | ARG154 | |
| B | LYS189 | |
| B | LYS196 | |
| B | ARG248 | |
| B | LYS272 | |
| B | ALA281 | |
| B | THR284 | |
| B | ARG286 | |
| B | ARG290 | |
| C | LYS152 | |
| C | ARG154 | |
| C | LYS189 | |
| C | LYS196 | |
| C | ARG248 | |
| C | LYS272 | |
| C | ALA281 | |
| C | THR284 | |
| C | ARG286 | |
| C | ARG290 | |
| D | LYS152 | |
| D | ARG154 | |
| D | LYS189 | |
| D | LYS196 | |
| D | ARG248 | |
| D | LYS272 | |
| D | ALA281 | |
| D | THR284 | |
| D | ARG286 | |
| D | ARG290 | |
| A | LYS152 | |
| A | ARG154 | |
| A | LYS196 | |
| A | LYS189 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:12931194 |
| Chain | Residue | Details |
| A | LYS238 | |
| B | LYS238 | |
| C | LYS238 | |
| D | LYS238 |
