Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5WFE

Cas1-Cas2-IHF-DNA holo-complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004520	molecular_function	DNA endonuclease activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0008821	molecular_function	crossover junction DNA endonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0017108	molecular_function	5'-flap endonuclease activity
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043571	biological_process	maintenance of CRISPR repeat elements
A	0046872	molecular_function	metal ion binding
A	0051607	biological_process	defense response to virus
A	0099048	biological_process	CRISPR-cas system
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0008821	molecular_function	crossover junction DNA endonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0017108	molecular_function	5'-flap endonuclease activity
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043571	biological_process	maintenance of CRISPR repeat elements
B	0046872	molecular_function	metal ion binding
B	0051607	biological_process	defense response to virus
B	0099048	biological_process	CRISPR-cas system
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004518	molecular_function	nuclease activity
C	0004519	molecular_function	endonuclease activity
C	0004520	molecular_function	DNA endonuclease activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0008821	molecular_function	crossover junction DNA endonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0017108	molecular_function	5'-flap endonuclease activity
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043571	biological_process	maintenance of CRISPR repeat elements
C	0046872	molecular_function	metal ion binding
C	0051607	biological_process	defense response to virus
C	0099048	biological_process	CRISPR-cas system
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004520	molecular_function	DNA endonuclease activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0008821	molecular_function	crossover junction DNA endonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0017108	molecular_function	5'-flap endonuclease activity
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043571	biological_process	maintenance of CRISPR repeat elements
D	0046872	molecular_function	metal ion binding
D	0051607	biological_process	defense response to virus
D	0099048	biological_process	CRISPR-cas system
E	0003677	molecular_function	DNA binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0005515	molecular_function	protein binding
E	0016787	molecular_function	hydrolase activity
E	0043571	biological_process	maintenance of CRISPR repeat elements
E	0051607	biological_process	defense response to virus
E	0099048	biological_process	CRISPR-cas system
F	0003677	molecular_function	DNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0005515	molecular_function	protein binding
F	0016787	molecular_function	hydrolase activity
F	0043571	biological_process	maintenance of CRISPR repeat elements
F	0051607	biological_process	defense response to virus
F	0099048	biological_process	CRISPR-cas system
K	0000976	molecular_function	transcription cis-regulatory region binding
K	0001216	molecular_function	DNA-binding transcription activator activity
K	0003677	molecular_function	DNA binding
K	0005829	cellular_component	cytosol
K	0006260	biological_process	DNA replication
K	0006310	biological_process	DNA recombination
K	0006351	biological_process	DNA-templated transcription
K	0006355	biological_process	regulation of DNA-templated transcription
K	0006417	biological_process	regulation of translation
K	0009295	cellular_component	nucleoid
K	0009893	biological_process	positive regulation of metabolic process
K	0030527	molecular_function	structural constituent of chromatin
K	0032993	cellular_component	protein-DNA complex
K	0043565	molecular_function	sequence-specific DNA binding
K	0045893	biological_process	positive regulation of DNA-templated transcription
L	0003677	molecular_function	DNA binding
L	0005694	cellular_component	chromosome
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006260	biological_process	DNA replication
L	0006310	biological_process	DNA recombination
L	0006351	biological_process	DNA-templated transcription
L	0006355	biological_process	regulation of DNA-templated transcription
L	0006417	biological_process	regulation of translation
L	0030527	molecular_function	structural constituent of chromatin
L	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00045
Number of Residues	20
Details	HISTONE_LIKE Bacterial histone-like DNA-binding proteins signature. GFgsFslhyRapRt.GrNPkT

Chain	Residue	Details
L	GLY47-THR66
K	GLY48-THR67

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26503043","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5DS5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26503043","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	182
Details	Region: {"description":"Sufficient for cleavage of ssRNA, ssDNA and Holliday junction DNA"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	24
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)