5WDK
A processive dipeptidyl aminopeptidase secreted from an established commensal bacterium P. distasonis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016020 | cellular_component | membrane |
| A | 0043418 | biological_process | L-homocysteine catabolic process |
| A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| B | 0009636 | biological_process | response to toxic substance |
| B | 0016020 | cellular_component | membrane |
| B | 0043418 | biological_process | L-homocysteine catabolic process |
| B | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008234 | molecular_function | cysteine-type peptidase activity |
| C | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| C | 0009636 | biological_process | response to toxic substance |
| C | 0016020 | cellular_component | membrane |
| C | 0043418 | biological_process | L-homocysteine catabolic process |
| C | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008234 | molecular_function | cysteine-type peptidase activity |
| D | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| D | 0009636 | biological_process | response to toxic substance |
| D | 0016020 | cellular_component | membrane |
| D | 0043418 | biological_process | L-homocysteine catabolic process |
| D | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008234 | molecular_function | cysteine-type peptidase activity |
| E | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| E | 0009636 | biological_process | response to toxic substance |
| E | 0016020 | cellular_component | membrane |
| E | 0043418 | biological_process | L-homocysteine catabolic process |
| E | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008234 | molecular_function | cysteine-type peptidase activity |
| F | 0009401 | biological_process | phosphoenolpyruvate-dependent sugar phosphotransferase system |
| F | 0009636 | biological_process | response to toxic substance |
| F | 0016020 | cellular_component | membrane |
| F | 0043418 | biological_process | L-homocysteine catabolic process |
| F | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue K A 501 |
| Chain | Residue |
| A | ASP271 |
| A | SER273 |
| A | GLU274 |
| A | GLU335 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue K A 502 |
| Chain | Residue |
| A | ASP78 |
| A | LEU79 |
| A | GLU81 |
| A | GLU126 |
| A | HOH602 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue T1O A 503 |
| Chain | Residue |
| A | GLN50 |
| A | ASN51 |
| A | ARG52 |
| A | ALA53 |
| A | GLY54 |
| A | THR55 |
| A | CYS56 |
| A | THR143 |
| A | HIS340 |
| A | TRP363 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue K B 501 |
| Chain | Residue |
| B | ASP78 |
| B | LEU79 |
| B | GLU81 |
| B | GLU126 |
| B | HOH611 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue K C 501 |
| Chain | Residue |
| C | ASP271 |
| C | SER273 |
| C | GLU335 |
| C | LYS383 |
| C | HOH643 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue K C 502 |
| Chain | Residue |
| C | ASP78 |
| C | LEU79 |
| C | GLU81 |
| C | GLU126 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue K D 501 |
| Chain | Residue |
| D | GLU66 |
| D | ASP78 |
| D | LEU79 |
| D | GLU81 |
| D | GLU126 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue K D 502 |
| Chain | Residue |
| D | ASP271 |
| D | SER273 |
| D | GLU274 |
| D | GLU335 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue K E 501 |
| Chain | Residue |
| E | ASP78 |
| E | LEU79 |
| E | GLU81 |
| E | GLU126 |
| E | HOH613 |
| E | HOH733 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue K E 502 |
| Chain | Residue |
| E | ASP271 |
| E | SER273 |
| E | GLU274 |
| E | GLU335 |
| E | LYS383 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue K F 501 |
| Chain | Residue |
| F | ASP271 |
| F | SER273 |
| F | GLU274 |
| F | GLU335 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue K F 502 |
| Chain | Residue |
| F | ASP78 |
| F | LEU79 |
| F | GLU81 |
| F | GLU126 |
| F | HOH601 |
| F | HOH726 |
| site_id | AD4 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide T1O B 502 and CYS B 56 |
| Chain | Residue |
| B | GLN50 |
| B | ASN51 |
| B | ARG52 |
| B | ALA53 |
| B | GLY54 |
| B | THR55 |
| B | TRP57 |
| B | CYS58 |
| B | TYR59 |
| B | SER60 |
| B | THR143 |
| B | HIS340 |
| B | GLY341 |
| B | TRP363 |
| site_id | AD5 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide T1O C 503 and CYS C 56 |
| Chain | Residue |
| C | GLN50 |
| C | ALA53 |
| C | GLY54 |
| C | THR55 |
| C | TRP57 |
| C | CYS58 |
| C | TYR59 |
| C | SER60 |
| C | THR143 |
| C | ASP339 |
| C | HIS340 |
| C | GLY341 |
| C | TRP363 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide T1O D 503 and CYS D 56 |
| Chain | Residue |
| D | GLN107 |
| D | THR143 |
| D | HIS340 |
| D | GLY341 |
| D | TRP363 |
| D | GLN50 |
| D | ARG52 |
| D | ALA53 |
| D | GLY54 |
| D | THR55 |
| D | TRP57 |
| D | CYS58 |
| D | TYR59 |
| D | SER60 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide T1O E 503 and CYS E 56 |
| Chain | Residue |
| E | GLN50 |
| E | ASN51 |
| E | ARG52 |
| E | ALA53 |
| E | GLY54 |
| E | THR55 |
| E | TRP57 |
| E | CYS58 |
| E | TYR59 |
| E | SER60 |
| E | THR143 |
| E | HIS340 |
| E | GLY341 |
| E | TRP363 |
| site_id | AD8 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide T1O F 503 and CYS F 56 |
| Chain | Residue |
| F | GLN50 |
| F | ARG52 |
| F | ALA53 |
| F | GLY54 |
| F | THR55 |
| F | TRP57 |
| F | CYS58 |
| F | TYR59 |
| F | SER60 |
| F | THR143 |
| F | ASP339 |
| F | HIS340 |
| F | GLY341 |
| F | TRP363 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QNrAGTCWCySS |
| Chain | Residue | Details |
| A | GLN50-SER61 |
