5WCF
Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0006284 | biological_process | base-excision repair |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008469 | molecular_function | obsolete histone arginine N-methyltransferase activity |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0010821 | biological_process | regulation of mitochondrion organization |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| A | 0035241 | molecular_function | protein-arginine omega-N monomethyltransferase activity |
| A | 0035242 | molecular_function | protein-arginine omega-N asymmetric methyltransferase activity |
| A | 0042054 | molecular_function | histone methyltransferase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0044020 | molecular_function | histone H4R3 methyltransferase activity |
| A | 0045652 | biological_process | regulation of megakaryocyte differentiation |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0070611 | molecular_function | histone H3R2 methyltransferase activity |
| A | 0070612 | molecular_function | histone H2AR3 methyltransferase activity |
| A | 0090068 | biological_process | positive regulation of cell cycle process |
| A | 0140938 | molecular_function | histone H3 methyltransferase activity |
| A | 2000059 | biological_process | negative regulation of ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | HIS57 |
| A | ALA113 |
| A | SER114 |
| A | PRO139 |
| A | VAL140 |
| A | GLU141 |
| A | GLU155 |
| A | MET166 |
| A | SER169 |
| A | HOH503 |
| A | HOH505 |
| A | MET60 |
| A | HOH513 |
| A | ARG66 |
| A | TRP78 |
| A | GLY90 |
| A | ALA91 |
| A | GLY92 |
| A | LEU96 |
| A | GLU112 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue A0S A 402 |
| Chain | Residue |
| A | TRP156 |
| A | GLY158 |
| A | TYR159 |
| A | GLY160 |
| A | LEU161 |
| A | LEU162 |
| A | HIS163 |
| A | GLU164 |
| A | SER165 |
| A | ALA189 |
| A | ILE236 |
| A | LEU256 |
| A | PHE292 |
| A | LEU343 |
| A | VAL355 |
| A | MET373 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue 144 A 403 |
| Chain | Residue |
| A | VAL56 |
| A | MET60 |
| A | GLU155 |
| A | MET157 |
| A | HIS163 |
| A | HIS317 |
| A | TRP318 |
| A | HOH536 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"32828318","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
