5W7F
Murine acyloxyacyl hydrolase (AOAH), S262A mutant, with lipid A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0008653 | biological_process | lipopolysaccharide metabolic process |
| A | 0009104 | biological_process | lipopolysaccharide catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050528 | molecular_function | acyloxyacyl hydrolase activity |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0008653 | biological_process | lipopolysaccharide metabolic process |
| B | 0009104 | biological_process | lipopolysaccharide catabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050528 | molecular_function | acyloxyacyl hydrolase activity |
| B | 0050728 | biological_process | negative regulation of inflammatory response |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:29343645 |
| Chain | Residue | Details |
| A | ALA262 | |
| B | ALA262 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29343645, ECO:0007744|PDB:5W7D, ECO:0007744|PDB:5W7E, ECO:0007744|PDB:5W7F |
| Chain | Residue | Details |
| A | ASP183 | |
| A | ASP222 | |
| A | ASP226 | |
| A | ASN228 | |
| A | ASN230 | |
| A | ILE232 | |
| A | GLU244 | |
| B | ASP183 | |
| B | ASP185 | |
| B | ASP187 | |
| B | HIS189 | |
| A | ASP185 | |
| B | ASP204 | |
| B | ASN206 | |
| B | ASP207 | |
| B | ASP209 | |
| B | VAL212 | |
| B | ASP222 | |
| B | ASP226 | |
| B | ASN228 | |
| B | ASN230 | |
| B | ILE232 | |
| A | ASP187 | |
| B | GLU244 | |
| A | HIS189 | |
| A | ASP204 | |
| A | ASN206 | |
| A | ASP207 | |
| A | ASP209 | |
| A | VAL212 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Interacts with lipopolysaccharide => ECO:0000250|UniProtKB:O18823 |
| Chain | Residue | Details |
| A | ARG344 | |
| B | ARG344 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN58 | |
| B | ASN58 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29343645, ECO:0007744|PDB:5W7E |
| Chain | Residue | Details |
| A | ASN206 | |
| B | ASN206 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29343645, ECO:0007744|PDB:5W7D |
| Chain | Residue | Details |
| A | ASN408 | |
| B | ASN408 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29343645, ECO:0007744|PDB:5W7F |
| Chain | Residue | Details |
| A | ASN465 | |
| B | ASN465 |
