5W6O
Choline Kinase Alpha in Complex with TCD-717
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue 9X1 A 501 |
| Chain | Residue |
| A | TYR148 |
| A | ASN337 |
| A | PHE341 |
| A | MET177 |
| A | GLU180 |
| A | PHE200 |
| A | PRO201 |
| A | TRP248 |
| A | THR252 |
| A | TYR256 |
| A | TYR333 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MES A 502 |
| Chain | Residue |
| A | ASP306 |
| A | GLN308 |
| A | GLU349 |
| A | TRP420 |
| A | TRP423 |
| A | PHE435 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR352 |
| A | ALA443 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | MET351 |
| A | HIS417 |
| A | ALA447 |
| A | HIS450 |
| A | GLN451 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | GLU217 |
| A | TRP350 |
| A | MET351 |
| A | ARG363 |
| A | LYS368 |
| B | GLU84 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MES B 502 |
| Chain | Residue |
| B | ASP306 |
| B | GLN308 |
| B | GLU349 |
| B | TRP420 |
| B | TYR440 |
| B | HOH620 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | TYR369 |
| B | HIS417 |
| B | HIS450 |
| B | GLN451 |
| B | LYS454 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide 9X1 B 501 and TRP B 248 |
| Chain | Residue |
| A | LEU179 |
| B | TYR148 |
| B | MET177 |
| B | PHE200 |
| B | PRO201 |
| B | PRO246 |
| B | LYS247 |
| B | LEU249 |
| B | PHE250 |
| B | GLY251 |
| B | THR252 |
| B | TYR256 |
| B | ASN305 |
| B | TYR333 |
| B | SER335 |
| B | ASN337 |
| B | PHE341 |
| B | LEU419 |
| B | TRP420 |
| B | TRP423 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide 9X1 B 501 and TRP B 248 |
| Chain | Residue |
| A | LEU179 |
| B | TYR148 |
| B | MET177 |
| B | PHE200 |
| B | PRO201 |
| B | PRO246 |
| B | LYS247 |
| B | LEU249 |
| B | PHE250 |
| B | GLY251 |
| B | THR252 |
| B | TYR256 |
| B | ASN305 |
| B | TYR333 |
| B | SER335 |
| B | ASN337 |
| B | PHE341 |
| B | LEU419 |
| B | TRP420 |
| B | TRP423 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17007874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20299452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3G15","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17007874","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2CKQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"34077757","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"34077757","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
