5W5C
Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| B | 0005484 | molecular_function | SNAP receptor activity |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016192 | biological_process | vesicle-mediated transport |
| C | 0000149 | molecular_function | SNARE binding |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0017075 | molecular_function | syntaxin-1 binding |
| E | 0006836 | biological_process | neurotransmitter transport |
| E | 0019905 | molecular_function | syntaxin binding |
| F | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 101 |
| Chain | Residue |
| C | HOH214 |
| C | HOH225 |
| C | HOH242 |
| D | HOH404 |
| D | HOH408 |
| D | HOH429 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 301 |
| Chain | Residue |
| D | HOH423 |
| F | LYS332 |
| F | TYR364 |
| F | HOH610 |
| F | HOH690 |
| F | HOH716 |
| A | HOH108 |
| D | SER154 |
| D | GLY155 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 501 |
| Chain | Residue |
| F | LYS301 |
| F | GLY306 |
| F | LEU307 |
| F | SER308 |
| F | ASN333 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL F 502 |
| Chain | Residue |
| A | VAL48 |
| A | HOH104 |
| D | LEU165 |
| F | LYS325 |
| F | LYS326 |
| F | LYS327 |
| F | HOH624 |
| F | HOH664 |
| F | HOH670 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL F 503 |
| Chain | Residue |
| F | ASN319 |
| F | LYS354 |
| F | TYR380 |
| F | HOH606 |
| F | HOH636 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL F 504 |
| Chain | Residue |
| B | GLU206 |
| C | ARG31 |
| C | HOH206 |
| F | GLN353 |
| F | LYS354 |
| F | TYR380 |
| F | HOH617 |
Functional Information from PROSITE/UniProt
| site_id | PS00914 |
| Number of Residues | 40 |
| Details | SYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V |
| Chain | Residue | Details |
| B | ARG198-VAL237 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type F (BoNT/F, botF)","evidences":[{"source":"PubMed","id":"8505288","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type D (BoNT/D, botD)","evidences":[{"source":"PubMed","id":"8175689","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"(Microbial infection) Cleavage; by C.botulinum neurotoxin type E (BoNT/E)","evidences":[{"source":"PubMed","id":"8243676","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8294407","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8103915","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60879","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"12459461","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 133 |
| Details | Domain: {"description":"C2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P46096","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
